In January 2003, Mieke joined the Faculty of Law of Maastricht University as a Phd researcher (Junior researcher) at the department of Private Law. In that same year she was awarded the Ius Commune Prize 2003 for her paper on the debt for equity swap, a comparative research into Dutch, Belgian, French, English and Swiss law.

In 2007 Mieke successfully defended her PhD on the topic of Corporate restructuring in case of financial difficulties; the position of shareholders and directors which focused on the division of powers and responsibilities between company organs when it comes to determining the future strategy within companies in financial difficulties.

After her PhD Mieke worked for several years as Assistant and later as Associate Professor within the Private Law Department of Maastricht University. In 2017 Mieke was appointed  Professor of Comparative and National Company Law and in 2019 she was, together with her colleague Rob Bauer, appointed to the Elverding Chair on Sustainable Business, Culture and Corporate Regulation. Mieke is also the Academic Director of the Institute for Corporate Law, Governance and Innovation Policies (ICGI) and PhD Counselor within the Graduate School of the Faculty of Law.

Mieke is a member of the editorial board of several journals amongst which European Company Law and TvOB. She is the programme leader of a research programme on legal persons in Europe within the Ius Commune research school and is Of Counsel at the law firm DVDW Advocaten.