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Dr J. Hoeks

Key publications
  • Wefers, J., van Moorsel, D., Hansen, J., Connell, N. J., Havekes, B., Hoeks, J., van Marken Lichtenbelt, W. D., Duez, H., Phielix, E., Kalsbeek, A., Boekschoten, M. V., Hooiveld, G. J., Hesselink, M. K. C., Kersten, S., Staels, B., Scheer, F. A. J. L., & Schrauwen, P. (2018). Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 115(30), 7789-7794. https://doi.org/10.1073/pnas.1722295115
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  • Dahlmans, D., Houzelle, A., Andreux, P., Jorgensen, J. A., Wang, X., de Windt, L. J., Schrauwen, P., Auwerx, J., & Hoeks, J. (2017). An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism. Molecular Metabolism, 6(11), 1429-1442. https://doi.org/10.1016/j.molmet.2017.08.007
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  • van Moorsel, D., Hansen, J., Havekes, B., Scheer, F. A. J. L., Jorgensen, J. A., Hoeks, J., Schrauwen-Hinderling, V. B., Duez, H., Lefebvre, P., Schaper, N. C., Hesselink, M. K. C., Staels, B., & Schrauwen, P. (2016). Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity. Molecular Metabolism, 5(8), 635-645. https://doi.org/10.1016/j.molmet.2016.06.012
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  • Dahlmans, D., Houzelle, A., Schrauwen, P., & Hoeks, J. (2016). Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease. Clinical Science, 130(11), 843-852. https://doi.org/10.1042/CS20150780
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  • Hanssen, M. J., Hoeks, J., Brans, B., van der Lans, A. A., Schaart, G., van den Driessche, J. J., Jorgensen, J. A., Boekschoten, M. V., Hesselink, M. K., Havekes, B., Kersten, S., Mottaghy, F. M., van Marken Lichtenbelt, W. D., & Schrauwen, P. (2015). Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nature Medicine, 21(8), 863-865. https://doi.org/10.1038/nm.3891
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  • van der Lans, A. A., Hoeks, J., Brans, B., Vijgen, G. H. E. J., Visser, M. G., Vosselman, M. J., Hansen, J., Jorgensen, J. A., Wu, J., Mottaghy, F. M., Schrauwen, P., & van Marken Lichtenbelt, W. D. (2013). Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. Journal of Clinical Investigation, 123(8), 3395-3403. https://doi.org/10.1172/JCI68993
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  • Wu, J., Bostrom, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A. H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., Huang, K., Tu, H., van Marken Lichtenbelt, W. D., Hoeks, J., Enerback, S., Schrauwen, P., & Spiegelman, B. M. (2012). Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell, 150(2), 366-376. https://doi.org/10.1016/j.cell.2012.05.016
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  • Hoeks, J., & Schrauwen, P. (2012). Muscle mitochondria and insulin resistance: a human perspective. Trends in Endocrinology and Metabolism, 23(9), 444-450. https://doi.org/10.1016/j.tem.2012.05.007
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  • Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., Kornips, C. F. P., Hesselink, M. K. C., Kunz, I., Schrauwen-Hinderling, V., Blaak, E. E., Auwerx, J., & Schrauwen, P. (2011). Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metabolism, 14(5), 612-22. https://doi.org/10.1016/j.cmet.2011.10.002
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  • Nabben, M., Shabalina, I. G., Kornips, C. F. P., Van Beurden, D., Cannon, B., Schrauwen, P., Nedergaard, J., & Hoeks, J. (2011). Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice. Biochimica et Biophysica Acta-bioenergetics, 1807(9), 1095-1105. https://doi.org/10.1016/j.bbabio.2011.04.003
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Recent publications
  • Andriessen, C., Rutters, F., Hoeks, J., Kalsbeek, A., Noordam, R., Rosendaal, F. R., van Heemst, D., Despres, J.-P., Raina, P., Campbell, D. J. T., Schrauwen, P., de Mutsert, R., & van der Velde, J. H. P. M. (2025). Amount and timing of physical activity in relation to sleep quality in the general middle-aged Dutch population: A cross-sectional analysis. Preventive Medicine Reports, 53, Article 103035. https://doi.org/10.1016/j.pmedr.2025.103035
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  • Karavetian, M., El Khoury, C. F., Rutters, F., Slebe, R., Lorenzetti, D., Blondin, D., Carpentier, A., Després, J.-P., Hoeks, J., Kalsbeek, A., de Mutsert, R., Pigeyre, M., Raina, P., Schrauwen, P., Serlie, M., Thieba, C., van der Velde, J., & Campbell, D. J. T. (2025). Effect of timed exercise interventions on patient-reported outcome measures: A systematic review. PLOS ONE, 20(5), Article e0321526. https://doi.org/10.1371/journal.pone.0321526
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  • Li, W., Schomakers, B. V., van Weeghel, M., Grevendonk, L., Vaz, F. M., Salomons, G. S., Schrauwen, P., Hoeks, J., Gao, A. W., Houtkooper, R. H., & Janssens, G. E. (2025). Plasma triacylglycerol length and saturation level mark healthy aging groups in humans. Geroscience, 47(2), 2567-2580. https://doi.org/10.1007/s11357-024-01453-0
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  • Slebe, R., Splinter, J. J., Schoonmade, L. J., Blondin, D. P., Campbell, D. J. T., Carpentier, A. C., Despres, J.-P., Hoeks, J., Kalsbeek, A., Raina, P., Schrauwen, P., Serlie, M. J., Stenvers, D. J., Yi, C.-X., de Mutsert, R., Beulens, J. W. J., & Rutters, F. (2025). The effect of altered sleep timing on glycaemic outcomes: Systematic review of human intervention studies. Diabetes Obesity & Metabolism, 27(3), 1172-1183. https://doi.org/10.1111/dom.16104
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  • Sellers, A. J., van Beek, S. M. M., Hashim, D., Baak, R., Pallubinsky, H., Moonen-Kornips, E., Schaart, G., Gemmink, A., Jorgensen, J. A., van de Weijer, T., Kalkhoven, E., Hooiveld, G. J., Kersten, S., Hesselink, M. K. C., Schrauwen, P., Hoeks, J., & Lichtenbelt, W. D. V. M. (2024). Cold acclimation with shivering improves metabolic health in adults with overweight or obesity. Nature Metabolism, 6(12), 2246-2253. Article 1516. https://doi.org/10.1038/s42255-024-01172-y
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  • Harmsen, J. F., Kotte, M., Habets, I., Bosschee, F., Frenken, K., Jorgensen, J. A., de Kam, S., Moonen-Kornips, E., Cissen, J., Doligkeit, D., van de Weijer, T., Erazo-Tapia, E., Buitinga, M., Hoeks, J., & Schrauwen, P. (2024). Exercise training modifies skeletal muscle clock gene expression but not 24-hour rhythmicity in substrate metabolism of men with insulin resistance. The Journal of Physiology, 602(23), 6417-6433. https://doi.org/10.1113/JP285523
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  • Mevenkamp, J., Bruls, Y. M. H., Mancilla, R., Grevendonk, L., Wildberger, J. E., Brouwers, K., Hesselink, M. K. C., Schrauwen, P., Hoeks, J., Houtkooper, R. H., Buitinga, M., de Graaf, R. A., Lindeboom, L., & Schrauwen-Hinderling, V. B. (2024). Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T. Nature Communications, 15(1), Article 9159. https://doi.org/10.1038/s41467-024-53292-4
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  • Talamonti, E., Davegardh, J., Kalinovich, A., van Beek, S. M. M., Dehvari, N., Halleskog, C., Bokhari, H. M., Hutchinson, D. S., Ham, S., Humphrys, L. J., Dijon, N. C., Motso, A., Sandstrom, A., Zacharewicz, E., Mutule, I., Suna, E., Spura, J., Ditrychova, K., Stoddart, L. A., ... Bengtsson, T. (2024). The novel adrenergic agonist ATR-127 targets skeletal muscle and brown adipose tissue to tackle diabesity and steatohepatitis. Molecular Metabolism, 85, Article 101931. https://doi.org/10.1016/j.molmet.2024.101931
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  • Janssens, G. E., Molenaars, M., Herzog, K., Grevendonk, L., Remie, C. M. E., Vervaart, M. A. T., Elfrink, H. L., Wever, E. J. M., Schomakers, B. V., Denis, S. W., Waterham, H. R., Pras-Raves, M. L., van Weeghel, M., van Kampen, A. H. C., Tammaro, A., Butter, L. M., van der Rijt, S., Florquin, S., Jongejan, A., ... Houtkooper, R. H. (2024). A conserved complex lipid signature marks human muscle aging and responds to short-term exercise. Nature aging, 4(5), 681-693. https://doi.org/10.1038/s43587-024-00595-2
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  • Slebe, R., Wenker, E., Schoonmade, L. J., Bouman, E. J., Blondin, D. P., Campbell, D. J. T., Carpentier, A. C., Hoeks, J., Raina, P., Schrauwen, P., Serlie, M. J., Jan Stenvers, D., de Mutsert, R., Beulens, J. W. J., & Rutters, F. (2024). The effect of preprandial versus postprandial physical activity on glycaemia: Meta-analysis of human intervention studies. Diabetes Research and Clinical Practice, 210, Article 111638. https://doi.org/10.1016/j.diabres.2024.111638
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https://www.researchgate.net/profile/Joris_Hoeks