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Dr J. Hoeks

Key publicaties
  • Wefers, J., van Moorsel, D., Hansen, J., Connell, N. J., Havekes, B., Hoeks, J., van Marken Lichtenbelt, W. D., Duez, H., Phielix, E., Kalsbeek, A., Boekschoten, M. V., Hooiveld, G. J., Hesselink, M. K. C., Kersten, S., Staels, B., Scheer, F. A. J. L., & Schrauwen, P. (2018). Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America, 115(30), 7789-7794. https://doi.org/10.1073/pnas.1722295115
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  • Dahlmans, D., Houzelle, A., Andreux, P., Jorgensen, J. A., Wang, X., de Windt, L. J., Schrauwen, P., Auwerx, J., & Hoeks, J. (2017). An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism. Molecular Metabolism, 6(11), 1429-1442. https://doi.org/10.1016/j.molmet.2017.08.007
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  • van Moorsel, D., Hansen, J., Havekes, B., Scheer, F. A. J. L., Jorgensen, J. A., Hoeks, J., Schrauwen-Hinderling, V. B., Duez, H., Lefebvre, P., Schaper, N. C., Hesselink, M. K. C., Staels, B., & Schrauwen, P. (2016). Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity. Molecular Metabolism, 5(8), 635-645. https://doi.org/10.1016/j.molmet.2016.06.012
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  • Dahlmans, D., Houzelle, A., Schrauwen, P., & Hoeks, J. (2016). Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease. Clinical Science, 130(11), 843-852. https://doi.org/10.1042/CS20150780
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  • Hanssen, M. J., Hoeks, J., Brans, B., van der Lans, A. A., Schaart, G., van den Driessche, J. J., Jorgensen, J. A., Boekschoten, M. V., Hesselink, M. K., Havekes, B., Kersten, S., Mottaghy, F. M., van Marken Lichtenbelt, W. D., & Schrauwen, P. (2015). Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nature Medicine, 21(8), 863-865. https://doi.org/10.1038/nm.3891
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  • van der Lans, A. A., Hoeks, J., Brans, B., Vijgen, G. H. E. J., Visser, M. G., Vosselman, M. J., Hansen, J., Jorgensen, J. A., Wu, J., Mottaghy, F. M., Schrauwen, P., & van Marken Lichtenbelt, W. D. (2013). Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. Journal of Clinical Investigation, 123(8), 3395-3403. https://doi.org/10.1172/JCI68993
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  • Wu, J., Bostrom, P., Sparks, L. M., Ye, L., Choi, J. H., Giang, A. H., Khandekar, M., Virtanen, K. A., Nuutila, P., Schaart, G., Huang, K., Tu, H., van Marken Lichtenbelt, W. D., Hoeks, J., Enerback, S., Schrauwen, P., & Spiegelman, B. M. (2012). Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell, 150(2), 366-376. https://doi.org/10.1016/j.cell.2012.05.016
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  • Hoeks, J., & Schrauwen, P. (2012). Muscle mitochondria and insulin resistance: a human perspective. Trends in Endocrinology and Metabolism, 23(9), 444-450. https://doi.org/10.1016/j.tem.2012.05.007
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  • Timmers, S., Konings, E., Bilet, L., Houtkooper, R. H., van de Weijer, T., Goossens, G. H., Hoeks, J., van der Krieken, S., Ryu, D., Kersten, S., Kornips, C. F. P., Hesselink, M. K. C., Kunz, I., Schrauwen-Hinderling, V., Blaak, E. E., Auwerx, J., & Schrauwen, P. (2011). Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metabolism, 14(5), 612-22. https://doi.org/10.1016/j.cmet.2011.10.002
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  • Nabben, M., Shabalina, I. G., Kornips, C. F. P., Van Beurden, D., Cannon, B., Schrauwen, P., Nedergaard, J., & Hoeks, J. (2011). Uncoupled respiration, ROS production, acute lipotoxicity and oxidative damage in isolated skeletal muscle mitochondria from UCP3-ablated mice. Biochimica et Biophysica Acta-bioenergetics, 1807(9), 1095-1105. https://doi.org/10.1016/j.bbabio.2011.04.003
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Recente publicaties
  • de Kam, S. S., van der Velde, J. H. P. M., Veelen, A., Jorgensen, J. A., Hoeks, J., & Schrauwen, P. (2026). Nocturnal fat oxidation is lower in older individuals with overweight/obesity, including those with type 2 diabetes, and is associated with fasting triglyceride levels. Diabetologia, 69(8), 2347-2359. https://doi.org/10.1007/s00125-026-06736-z
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  • Janssens, G. E., Tretowicz, M. M., Grevendonk, L., Kotte, M., Scantlebery, A., Schomakers, B. V., van Weeghel, M., Hermans, J., Vervaart, M. A. T., Wever, E. J. M., Denis, S. W., Jongejan, A., Salomons, G. S., Vaz, F. M., Schrauwen, P., Hoeks, J., & Houtkooper, R. H. (2026). Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle. Nature aging, 6(7), 1482-1500. https://doi.org/10.1038/s43587-026-01150-x
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  • Schipper, S. B. J., Slebe, R., Schoonmade, L. J., Blondin, D. P., Campbell, D. J. T., Carpentier, A. C., Despres, J.-P. P., Hoeks, J., Kalsbeek, A., Raina, P., Schrauwen, P., Serlie, M. J., Stenvers, D. J., Yi, C.-X., de Mutsert, R., Beulens, J. W. J., & Rutters, F. (2026). The effect of timing of physical exercise on glycemia: a systematic review and meta-analysis of human intervention studies. Journal of Diabetes and Metabolic Disorders, 25(1), Article 150. https://doi.org/10.1007/s40200-026-01954-z
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  • Joshi, D., Rafiq, T., Pigeyre, M., de Mutsert, R., Rutters, F., Campbell, D. J. T., Desprest, J.-P., Carpentier, A. C., Hoeks, J., Schrauwen, P., & Raina, P. (2026). Circulating Rhythmic Metabolites and Causal Risk of Type 2 Diabetes in Adults in the Canadian Longitudinal Study on Aging. Diabetes Obesity & Metabolism, 28(5), 4243-4252. https://doi.org/10.1111/dom.70616
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  • Van Lier, P. M. G., van de Weijer, T., Vanweert, F., Brouwers, K., Nijssen, K. M. R., Schaart, G., Moonen-Kornips, E., van Beek, S. M. M., Springer, S., Wierts, R., Joris, P. J., Schrauwen-Hinderling, V. B., Phielix, E., Bengtsson, T., Schrauwen, P., & Hoeks, J. (2026). Prolonged β2-agonist treatment enhances muscle-specific glucose uptake in individuals with overweight and obesity: a randomized placebo-controlled trial. Nature Communications, 17(1), Article 5483. https://doi.org/10.1038/s41467-026-71897-9
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  • Trinks, N., Gancheva, S., Pützer, J., Schön, M., Huttasch, M., Pafili, K., Mastrototaro, L., Dewidar, B., Kupriyanova, Y., Herder, C., Strassburger, K., Zaharia, O. P., Ruppert, P. M. M., Kersten, S., Hoeks, J., Trenkamp, S., Schrauwen-Hinderling, V., Schrauwen, P., Roden, M., & Pesta, D. H. (2026). Blood-flow restriction resistance training improves skeletal muscle mitochondrial capacity and cardiovascular risk factors in type 2 diabetes. Cell Metabolism, 38(4), 812-823.e6. https://doi.org/10.1016/j.cmet.2025.12.016
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  • Lu, J. K., Wang, W., Guan, L., Van Der Velde, J., Hoeks, J., Schrauwen, P., Salomons, G. S., Houtkooper, R. H., Maier, A. B., & Janssens, G. E. (2026). A scalable step count-based predictor of biological age: development and validation of MoveIt! Age in community-dwelling adults and geriatric rehabilitation inpatients. Geroscience, 48(2), 1553-1570. https://doi.org/10.1007/s11357-025-01999-7
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  • Campbell, D. B., Reed, T., Slebe, R., Raina, P., Rutters, F., Joshi, D., de Mutsert, R., Despres, J.-P., Hoeks, J., Blondin, D. P., Carpentier, A., Schrauwen, P., & Campbell, D. J. T. (2026). Socioeconomic determinants of shift work employment in Canada and the Netherlands: a cross-sectional analysis of data from the Canadian Longitudinal Study on Aging and the Hoorn Study. Frontiers in Public Health, 14, Article 1699140. https://doi.org/10.3389/fpubh.2026.1699140
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  • Slebe, R., Wenker, E., Schoonmade, L. J., Bouman, E. J., Blondin, D. P., Campbell, D. J. T., Carpentier, A. C., Hoeks, J., Raina, P., Schrauwen, P., Serlie, M. J., Stenvers, D. J., de Mutsert, R., Beulens, J. W. J., & Rutters, F. (2026). Corrigendum to “The effect of preprandial versus postprandial physical activity on glycaemia: Meta-analysis of human intervention studies”. [Diabetes Res. Clin. Pract. 210 (2024) 111638] (Diabetes Research and Clinical Practice (2024) 210, (S0168822724001281), (10.1016/j.diabres.2024.111638)). Diabetes Research and Clinical Practice, 233, Article 113143. https://doi.org/10.1016/j.diabres.2026.113143
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  • Harmsen, J. F., Habets, I., Biancolin, A. D., Lesniewska, A., Phillips, N. E., Metz, L., Sanchez-Avila, J., Kotte, M., Timmermans, M., Hashim, D., de Kam, S. S., Schaart, G., Jörgensen, J. A., Gemmink, A., Moonen-Kornips, E., Doligkeit, D., van de Weijer, T., Buitinga, M., Haans, F., ... Hoeks, J. (2026). Natural daylight during office hours improves glucose control and whole-body substrate metabolism. Cell Metabolism, 38(1), 65-81.e10. https://doi.org/10.1016/j.cmet.2025.11.006
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