Prof Dr Theo de Kok (T.M.C.M.)

Goldring, C. E., Russomanno, G., Pin, C., Trairatphisan, P., Beattie, K. A., Fisher, C. P., Pinero, J., Brennan, R. J., Clausznitzer, D., Copple, I. M., de Kok, T. M., Duckworth, C. A., Furlong, L. I., Fuzi, B., Gabor, A., Gall, L., Hengstler, J., Hermjakob, H., Hunter, F., ... Laplanche, L. (2025). Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety. Nature Reviews Drug Discovery. https://doi.org/10.1038/s41573-025-01308-z

Jiang, J., van Ertvelde, J., Ertaylan, G., Peeters, R., Jennen, D., de Kok, T., & Vinken, M. (2025). Leveraging artificial intelligence and machine learning for predicting chemical-induced cholestasis. Toxicology Letters, 411. https://doi.org/10.1016/j.toxlet.2025.07.129

He, Y., Debenedictis, J. N., van Breda, S. G., & de Kok, T. M. (2025). Unveiling Cell-Type-Specific Immune Reactions in Human Blood Following Varied Fruit and Vegetable Blends Interventions. Molecular Nutrition & Food Research, Article e70238. https://doi.org/10.1002/mnfr.70238

He, Y., van Breda, S. G. J., & de Kok, T. M. C. M. (2025). Employing human intestinal organoids as advanced in vitro models for mechanistic studies on dietary ingredients. Critical Reviews in Food Science and Nutrition. https://doi.org/10.1080/10408398.2025.2550515

Bwanya, B., Lodhi, S., de Kok, T. M., Ladeira, L., Verheijen, M. C., Jennen, D. G., & Caiment, F. (2025). Machine learning classification of steatogenic compounds using toxicogenomics profiles. Toxicology, 517, Article 154237. https://doi.org/10.1016/j.tox.2025.154237

Bischoff, N. S., Undas, A. K., van Herwijnen, M., Verheijen, M., Briedé, J. J., van Breda, S. G., Sijm, D. T. H. M., & de Kok, T. M. (2025). E171-induced toxicity in human iPSC-derived colon organoids: Effects on cell viability, ROS generation, DNA damage, and gene expression changes. Toxicology in Vitro, 108, Article 106105. https://doi.org/10.1016/j.tiv.2025.106105

DeBenedictis, J. N., Xu, N., de Kok, T. M., & van Breda, S. G. (2025). The MiBlend Randomized Trial: Investigating Genetic Polymorphisms in Personalized Responses to Fruit and Vegetable Interventions for Chronic Disease Prevention. Antioxidants, 14(7), Article 828. https://doi.org/10.3390/antiox14070828

DeBenedictis, J. N., Xu, N., de Kok, T. M., & van Breda, S. G. (2025). The Role of Genetic Variation in Modulating the Effects of Blended Fruits and Vegetables Versus Fruit- and Vegetable-Coated Food Products on Antioxidant Capacity, DNA Protection, and Vascular Health: A Randomized Controlled Trial. Nutrients, 17(12), Article 2036. https://doi.org/10.3390/nu17122036

Bischoff, N. S., Bussi, M. R., Van Breda, S. G., Jolani, S., Sijm, D. T. H. M., de Kok, T. M., & Briede, J. J. (2025). Food-grade titanium dioxide exposure between age groups and in global regions: a systematic review and meta-analysis. Critical Reviews in Food Science and Nutrition. https://doi.org/10.1080/10408398.2025.2467823

Bischoff, N. S., Undas, A. K., van Bemmel, G., Briedé, J. J., van Breda, S. G., Verhoeven, J., Verbruggen, S., Venema, K., Sijm, D. T. H. M., & de Kok, T. M. (2025). Investigating the ROS Formation and Particle Behavior of Food-Grade Titanium Dioxide (E171) in the TIM-1 Dynamic Gastrointestinal Digestion Model. Nanomaterials, 15(1), Article 8. https://doi.org/10.3390/nano15010008