Drs M.R. Losen

Arets, B., Mané-Damas, M., Schöttler, A. K., Sikorski, P. M., Kusner, L. L., Kaminski, H. J., Losen, M., & Martinez-Martinez, P. (2025). Refinement of the rat acetylcholine receptor-specific passive transfer myasthenia gravis model using subcutaneous injections: an update to the guidelines. Scientific Reports, 15(1), Article 33062. https://doi.org/10.1038/s41598-025-15187-2

Mané-Damas, M., Schöttler, A. K., Marcuse, F., Molenaar, P., Mohile, T., Hoeijmakers, J., Hochstenbag, M., Damoiseaux, J., Maessen, J., Abdul-Hamid, M., Zur Hausen, A., de Baets, M., Losen, M., & Martinez-Martinez, P. (2025). Myasthenia gravis with antibodies against the AChR, current knowledge on pathophysiology and an update on treatment strategies with special focus on targeting plasma cells. Autoimmunity Reviews, 24(10), Article 103875. https://doi.org/10.1016/j.autrev.2025.103875

Mane-Damas, M., Schottler, A. K., Mohile, T., Arets, B., Tuzun, E., Losen, M., & Martinez-Martinez, P. (2025). Hock immunization, a refined alternative for developing experimental autoimmune myasthenia gravis (EAMG) in mice. Scientific Reports, 15(1), Article 31893. https://doi.org/10.1038/s41598-025-12446-0

van de Burgt, N. A., Kulsvehagen, L., Mane-Damas, M., Lutz, L., Lecourt, A.-C., Monserrat, C., Vinke, A. M., Kucukali, C. I., Zong, S., Hoffmann, C., Gonzalez-Vioque, E., Arango, C., Leibold, N. K., Losen, M., Molenaar, P. C., Tuzun, E., van Beveren, N. J. M., Mane, A., Rouhl, R. P. W., ... Genetic Risk Outcome Psychosis GROUP Investigators (2025). Autoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptoms. Frontiers in Neurology, 16, Article 1593042. https://doi.org/10.3389/fneur.2025.1593042

van Kruining, D., Losen, M., Dehairs, J., Swinnen, J. V., Waelkens, E., Honing, M., & Martinez-Martinez, P. (2025). Early plasma ceramide and sphingomyelin levels reflect APOE genotype but not familial Alzheimer's disease gene mutations in female 5xFAD mice, with brain-region specific sphingolipid alterations. Neurobiology of Disease, 210, Article 106923. https://doi.org/10.1016/j.nbd.2025.106923

Mane-Damas, M., Saxena, A., Nogales-Gadea, G., Stevens, J., Vincken, S., van Beek, M., van den Hoogen, N. J., Joosten, E. A. J., Willcox, N., Duimel, H., Maessen, J. G., Molenaar, P. C., De Baets, M. H., Losen, M., & Martinez-Martinez, P. (2025). Efficacy of MLN9708 (ixazomib) in experimental autoimmune myasthenia gravis and in anti-AChR producing primary thymic cell cultures from myasthenia gravis patients. Frontiers in Immunology, 16, Article 1521432. https://doi.org/10.3389/fimmu.2025.1521432

den Hoedt, S., Crivelli, S. M., Dorst-Lagerwerf, K. Y., Leijten, F. P. J., Losen, M., de Vries, H. E., Sijbrands, E. J. G., Verhoeven, A. J. M., Martinez-Martinez, P., & Mulder, M. T. (2024). The effects of APOE4 and familial Alzheimer's disease mutations on free fatty acid profiles in mouse brain are age- and sex-dependent. Journal of Neurochemistry, 168(9), 3063-3075. https://doi.org/10.1111/jnc.16176

Koneczny, I., Mane-Damas, M., Zong, S., De Haas, S., Huda, S., van Kruining, D., Damoiseaux, J., De Rosa, A., Maestri, M., Guida, M., Molenaar, P., Van Damme, P., Fichtenbaum, A., Perkmann, T., De Baets, M., Lazaridis, K., Zouvelou, V., Tzartos, S., Ricciardi, R., ... Martinez-Martinez, P. (2024). A retrospective multicenter study on clinical and serological parameters in patients with MuSK myasthenia gravis with and without general immunosuppression. Frontiers in Immunology, 15, Article 1325171. https://doi.org/10.3389/fimmu.2024.1325171

Luo, Q., Crivelli, S. M., Zong, S., Giovagnoni, C., van Kruining, D., Mane-Damas, M., den Hoedt, S., Berkes, D., De Vries, H. E., Mulder, M. T., Walter, J., Waelkens, E., Derua, R., Swinnen, J., Dehairs, J., Losen, M., & Martinez-Martinez, P. (2024). The Effect of FTY720 on Sphingolipid Imbalance and Cognitive Decline in Aged EFAD Mice. Journal of Alzheimer's Disease Reports, 8(1), 1317-1327. https://doi.org/10.3233/ADR-230053

van Kruining, D., Losen, M., Crivelli, S. M., de Jong, J. J. A., Jansen, J. F. A., Backes, W. H., Monereo-Sánchez, J., van Boxtel, M. P. J., Köhler, S., Linden, D. E. J., Schram, M. T., Mielke, M. M., & Martinez-Martinez, P. (2023). Plasma ceramides relate to mild cognitive impairment in middle-aged men: The Maastricht Study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 15(3), Article e12459. https://doi.org/10.1002/dad2.12459