Drs M.R. Losen

van Kruining, D., Losen, M., Dehairs, J., Swinnen, J. V., Waelkens, E., Honing, M., & Martinez-Martinez, P. (2025). Early plasma ceramide and sphingomyelin levels reflect APOE genotype but not familial Alzheimer's disease gene mutations in female 5xFAD mice, with brain-region specific sphingolipid alterations. Neurobiology of Disease, 210, Article 106923. Advance online publication. https://doi.org/10.1016/j.nbd.2025.106923

den Hoedt, S., Crivelli, S. M., Dorst-Lagerwerf, K. Y., Leijten, F. P. J., Losen, M., de Vries, H. E., Sijbrands, E. J. G., Verhoeven, A. J. M., Martinez-Martinez, P., & Mulder, M. T. (2024). The effects of APOE4 and familial Alzheimer's disease mutations on free fatty acid profiles in mouse brain are age- and sex-dependent. Journal of Neurochemistry, 168(9), 3063-3075. https://doi.org/10.1111/jnc.16176

Koneczny, I., Mane-Damas, M., Zong, S., De Haas, S., Huda, S., van Kruining, D., Damoiseaux, J., De Rosa, A., Maestri, M., Guida, M., Molenaar, P., Van Damme, P., Fichtenbaum, A., Perkmann, T., De Baets, M., Lazaridis, K., Zouvelou, V., Tzartos, S., Ricciardi, R., ... Martinez-Martinez, P. (2024). A retrospective multicenter study on clinical and serological parameters in patients with MuSK myasthenia gravis with and without general immunosuppression. Frontiers in Immunology, 15, Article 1325171. https://doi.org/10.3389/fimmu.2024.1325171

Luo, Q., Crivelli, S. M., Zong, S., Giovagnoni, C., van Kruining, D., Mane-Damas, M., den Hoedt, S., Berkes, D., De Vries, H. E., Mulder, M. T., Walter, J., Waelkens, E., Derua, R., Swinnen, J., Dehairs, J., Losen, M., & Martinez-Martinez, P. (2024). The Effect of FTY720 on Sphingolipid Imbalance and Cognitive Decline in Aged EFAD Mice. Journal of Alzheimer's Disease Reports, 8(1), 1317-1327. https://doi.org/10.3233/ADR-230053

van Kruining, D., Losen, M., Crivelli, S. M., de Jong, J. J. A., Jansen, J. F. A., Backes, W. H., Monereo-Sánchez, J., van Boxtel, M. P. J., Köhler, S., Linden, D. E. J., Schram, M. T., Mielke, M. M., & Martinez-Martinez, P. (2023). Plasma ceramides relate to mild cognitive impairment in middle-aged men: The Maastricht Study. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 15(3), Article e12459. https://doi.org/10.1002/dad2.12459

Zong, S., Vinke, A. M., Du, P., Hoffmann, C., Mané-Damas, M., Molenaar, P. C., Damoiseaux, J. G. M. C., Losen, M., Rouhl, R. P. W., & Martinez-Martinez, P. (2023). Anti-GAD65 autoantibody levels measured by ELISA and alternative types of immunoassays in relation to neuropsychiatric diseases versus diabetes mellitus type 1. Frontiers in Neurology, 14(1), Article 1111063. https://doi.org/10.3389/fneur.2023.1111063

Fichtner, M. L., Hoehn, K. B., Ford, E. E., Mane-Damas, M., Oh, S., Waters, P., Payne, A. S., Smith, M. L., Watson, C. T., Losen, M., Martinez-Martinez, P., Nowak, R. J., Kleinstein, S. H., & O'Connor, K. C. (2022). Reemergence of pathogenic, autoantibody-producing B cell clones in myasthenia gravis following B cell depletion therapy. Acta neuropathologica communications, 10(1), Article 154. https://doi.org/10.1186/s40478-022-01454-0

Crivelli, S. M., Luo, Q., van Kruining, D., Giovagnoni, C., Mane-Damas, M., den Hoedt, S., Berkes, D., De Vries, H. E., Mulder, M. T., Walter, J., Waelkens, E., Derua, R., Swinnen, J. V., Dehairs, J., Wijnands, E. P. M., Bieberich, E., Losen, M., & -Martinez, P. M. (2022). FTY720 decreases ceramides levels in the brain and prevents memory impairments in a mouse model of familial Alzheimer's disease expressing APOE4. Biomedicine & Pharmacotherapy, 152, Article 113240. https://doi.org/10.1016/j.biopha.2022.113240

Vinke, A. M., Zong, S., Janssen, J. H., Correia-Hoffmann, C., Mané-Damas, M., Damoiseaux, J. G. M. C., de Vries, J. M., Pröpper, D., Molenaar, P., Losen, M., Martinez Martinez, P., & Rouhl, R. P. W. (2022). Autoimmune Encephalitis With mGluR1 Antibodies Presenting With Epilepsy, but Without Cerebellar Signs: A Case Report. Neurology: Neuroimmunology & Neuroinflammation, 9(4), Article e1171. https://doi.org/10.1212/NXI.0000000000001171

Mané-Damas, M., Molenaar, P. C., Ulrichts, P., Marcuse, F., De Baets, M. H., Martinez-Martinez, P., & Losen, M. (2022). Novel treatment strategies for acetylcholine receptor antibody-positive myasthenia gravis and related disorders. Autoimmunity Reviews, 21(7), Article 103104. https://doi.org/10.1016/j.autrev.2022.103104