Drs M.R. Losen

Arets, B., Peng, S., Bracke, L., De Winter, K., Delaere, J., Driege, Y., Delahaye, T., Moshir, M., Van de Walle, I., Ulrichts, P., Mane-Damas, M., Losen, M., & Martinez-Martinez, P. (2026). Anti-C2-mediated complement inhibition prevents disease in a rat passive transfer model of myasthenia gravis. Journal of Translational Autoimmunity, 13, Article 100388. https://doi.org/10.1016/j.jtauto.2026.100388

Du, P., Mane-Damas, M., Verhamme, F. M., Moshir, M., Ulrichts, P., Machiels, B., Losen, M., & Martinez-Martinez, P. (2026). Optimization of the Cell-Based Assay Methodology to Study Degradation of Acetylcholine Receptors (Antigenic Modulation) by Antibodies From Myasthenia Gravis Patients. Muscle & Nerve, 74(S1), S150-S158. https://doi.org/10.1002/mus.70319

Arets, B., Mané-Damas, M., Schöttler, A. K., Sikorski, P. M., Kusner, L. L., Kaminski, H. J., Losen, M., & Martinez-Martinez, P. (2025). Refinement of the rat acetylcholine receptor-specific passive transfer myasthenia gravis model using subcutaneous injections: an update to the guidelines. Scientific Reports, 15(1), Article 33062. https://doi.org/10.1038/s41598-025-15187-2

Mané-Damas, M., Schöttler, A. K., Marcuse, F., Molenaar, P., Mohile, T., Hoeijmakers, J., Hochstenbag, M., Damoiseaux, J., Maessen, J., Abdul-Hamid, M., Zur Hausen, A., de Baets, M., Losen, M., & Martinez-Martinez, P. (2025). Myasthenia gravis with antibodies against the AChR, current knowledge on pathophysiology and an update on treatment strategies with special focus on targeting plasma cells. Autoimmunity Reviews, 24(10), Article 103875. https://doi.org/10.1016/j.autrev.2025.103875

Mane-Damas, M., Schottler, A. K., Mohile, T., Arets, B., Tuzun, E., Losen, M., & Martinez-Martinez, P. (2025). Hock immunization, a refined alternative for developing experimental autoimmune myasthenia gravis (EAMG) in mice. Scientific Reports, 15(1), Article 31893. https://doi.org/10.1038/s41598-025-12446-0

van de Burgt, N. A., Kulsvehagen, L., Mane-Damas, M., Lutz, L., Lecourt, A.-C., Monserrat, C., Vinke, A. M., Kucukali, C. I., Zong, S., Hoffmann, C., Gonzalez-Vioque, E., Arango, C., Leibold, N. K., Losen, M., Molenaar, P. C., Tuzun, E., van Beveren, N. J. M., Mane, A., Rouhl, R. P. W., ... Genetic Risk Outcome Psychosis GROUP Investigators (2025). Autoantibodies against myelin oligodendrocyte glycoprotein in a subgroup of patients with psychotic symptoms. Frontiers in Neurology, 16, Article 1593042. https://doi.org/10.3389/fneur.2025.1593042

van Kruining, D., Losen, M., Dehairs, J., Swinnen, J. V., Waelkens, E., Honing, M., & Martinez-Martinez, P. (2025). Early plasma ceramide and sphingomyelin levels reflect APOE genotype but not familial Alzheimer's disease gene mutations in female 5xFAD mice, with brain-region specific sphingolipid alterations. Neurobiology of Disease, 210, Article 106923. https://doi.org/10.1016/j.nbd.2025.106923

Mane-Damas, M., Saxena, A., Nogales-Gadea, G., Stevens, J., Vincken, S., van Beek, M., van den Hoogen, N. J., Joosten, E. A. J., Willcox, N., Duimel, H., Maessen, J. G., Molenaar, P. C., De Baets, M. H., Losen, M., & Martinez-Martinez, P. (2025). Efficacy of MLN9708 (ixazomib) in experimental autoimmune myasthenia gravis and in anti-AChR producing primary thymic cell cultures from myasthenia gravis patients. Frontiers in Immunology, 16, Article 1521432. https://doi.org/10.3389/fimmu.2025.1521432

den Hoedt, S., Crivelli, S. M., Dorst-Lagerwerf, K. Y., Leijten, F. P. J., Losen, M., de Vries, H. E., Sijbrands, E. J. G., Verhoeven, A. J. M., Martinez-Martinez, P., & Mulder, M. T. (2024). The effects of APOE4 and familial Alzheimer's disease mutations on free fatty acid profiles in mouse brain are age- and sex-dependent. Journal of Neurochemistry, 168(9), 3063-3075. https://doi.org/10.1111/jnc.16176

Koneczny, I., Mane-Damas, M., Zong, S., De Haas, S., Huda, S., van Kruining, D., Damoiseaux, J., De Rosa, A., Maestri, M., Guida, M., Molenaar, P., Van Damme, P., Fichtenbaum, A., Perkmann, T., De Baets, M., Lazaridis, K., Zouvelou, V., Tzartos, S., Ricciardi, R., ... Martinez-Martinez, P. (2024). A retrospective multicenter study on clinical and serological parameters in patients with MuSK myasthenia gravis with and without general immunosuppression. Frontiers in Immunology, 15, Article 1325171. https://doi.org/10.3389/fimmu.2024.1325171