PhD Defence Maria Gabriella Fois
Supervisors: Prof. Dr. Roman Truckenmüller, Prof. Dr. Pamela Habibović
Co-supervisors: Dr. Stefan Giselbrecht, Dr. Zeinab Niloofar Tahmasebi Birgani
Keywords: 3D culture, microphysiological systems, biomaterials, in vitro models
"Miniaturized 3D in vitro models for material-guided bone regeneration"
Tissue engineering and regenerative medicine (TERM) aim at the development of replacements for lost, damaged or diseased tissues/organs. TERM relies on the use of cells, biomaterials and growth factors. Since biomaterials play a major role in TERM research, their characterization and assessment are of great importance. Conventionally, the assessment of safety and functionality of biomaterials is based on in vitro cultures of cells on two-dimensional (2D) specimens of the material of interest. The relevance of such an experiment is limited, as it poorly represents the actual environment in the body. This drawback has inspired researchers to develop more predictive in vitro models to test materials for biomedical applications. As a contribution to these efforts, this thesis focuses on the development of three-dimensional miniaturized human in vitro models of bone with the aim of assessing cell-biomaterial interactions in a native-like setting.
Click here for the full dissertation.
Click here for the live stream.
Also read
-
PhD Defence Emmanuel Tan Chee Peng
"Beyond Hogwarts and Sorting Hats: How a House System shapes medical student support"
10 Jun -
PhD Defence Mariia Denisova
"Co-construction of reliable knowledge, good care and profit-making: The ambivalent role of private clinics in Russian healthcare"
10 Jun -
PhD Defence Charlotte Merel Marije Peters
"Beyond The Red Lights: Understanding the STI/HIV burden and sexual healthcare needs of home-based and migrant sex workers"
11 Jun