PhD defence Aäron Frans Jacob Iding

Keywords: Deep vein thrombosis, Post-thrombotic syndrome, Residual venous obstruction, Recurrent venous thromboembolism

"Residual Venous Obstruction And Long-Term Outcomes After Deep Vein Thrombosis: Towards Improved Prediction And Prevention"

This PhD research explored why some patients after a deep vein thrombosis (DVT) continue to experience leg complaints, referred to as post-thrombotic syndrome (PTS). The focus was on residual venous obstruction – a partial blockage that may remain in the vein even after standard treatment. Using data from large patient studies and clinical trials, the research investigated how imaging findings, inflammation, and blood-clotting activity influence long-term recovery. It showed that persistent vein obstruction is linked to PTS and arterial thrombosis, but not to new venous thrombosis. The work also identified different patient profiles with varying risks and examined potential mechanisms. Finally, a pilot trial tested the compound oxerutin, which showed promising results in reducing vein obstruction, which may provide an additional therapy to prevent PTS. Together, these findings provide new insight into how and why recovery after DVT differs between patients, paving the way for more personalized treatment.

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