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C.C.J.M. Simons

Research profile

I am the principal investigator in the Netherlands Cohort Study since 2024. Our research focus is on developing a better understanding of the etiology and prognosis of cancer by taking into account tumor heterogeneity. We differentiate molecular tumor subtypes based on mutations found in the tumor or differences in protein expression in the  tumor. Our current focus is on colorectal and breast cancer.

 

I am also involved in the Energy for life after ColoRectal cancer (ENCORE) study. My research focus within EnCoRe is on chemotherapy-induced peripheral neuropathy (CIPN), which affects many colorectal cancer patients treated with an oxaliplatin-containing regimen for years after treatment. Our current focus is on investigating the role of body composition in the dosing of oxaliplatin and the development and course of neuropathic complaints. 

 

Key publications
  • Jenniskens, J. C. A., Offermans, K., Simons, C. C. J. M., Samarska, I., Fazzi, G. E., Smits, K. M., Schouten, L. J., Weijenberg, M. P., Grabsch, H. I., & van den Brandt, P. A. (2022). Energy Balance-Related Factors and Risk of Colorectal Cancer Expressing Different Levels of Proteins Involved in the Warburg Effect. Cancer Epidemiology Biomarkers & Prevention, 31(3), 633-646. https://doi.org/10.1158/1055-9965.epi-21-0678
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  • Jenniskens, J. C. A., Offermans, K., Simons, C. C. J. M., Samarska, I., Fazzi, G. E., van der Meer, J. R. M., Smits, K. M., Schouten, L. J., Weijenberg, M. P., Grabsch, H. I., & van den Brandt, P. A. (2022). Energy balance-related factors and risk of colorectal cancer based on KRAS, PIK3CA, and BRAF mutations and MMR status. Journal of Cancer Research and Clinical Oncology, 148(10), 2723-2742. https://doi.org/10.1007/s00432-022-04019-9
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  • Jenniskens, J. C. A., Offermans, K., Simons, C. C. J. M., Samarska, I., Fazzi, G. E., van der Meer, J. R. M., Smits, K. M., Schouten, L. J., Weijenberg, M. P., Grabsch, H. I., & Brandt, P. A. V. D. (2022). Energy balance-related factors in childhood and adolescence and risk of colorectal cancer based on KRAS, PIK3CA, and BRAF mutations and MMR status. Molecular Carcinogenesis, 61(12), 1099-1115. https://doi.org/10.1002/mc.23459
    More information about this publication
  • Offermans, K., Jenniskens, J. C. A., Simons, C. C. J. M., Samarska, I., Fazzi, G. E., van der Meer, J. R. M., Smits, K. M., Schouten, L. J., Weijenberg, M. P., Grabsch, H. I., & van den Brandt, P. A. (2023). Association between mutational subgroups, Warburg-subtypes, and survival in patients with colorectal cancer. Cancer Medicine, 12(2), 1137-1156. https://doi.org/10.1002/cam4.4968
    More information about this publication
  • Offermans, K., Jenniskens, J. C. A., Simons, C. C. J. M., Samarska, I., Fazzi, G. E., Smits, K. M., Schouten, L. J., Weijenberg, M. P., Grabsch, H. I., & van den Brandt, P. A. (2023). Association between adjuvant therapy and survival in colorectal cancer patients according to metabolic Warburg-subtypes. Journal of Cancer Research and Clinical Oncology, 149(9), 6271-6282. https://doi.org/10.1007/s00432-023-04581-w
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  • Offermans, K., Reitsam, N. G., Simons, C. C. J. M., Grosser, B., Zimmermann, J., Grabsch, H. I., Märkl, B., & van den Brandt, P. A. (2024). The relationship between Stroma AReactive Invasion Front Areas (SARIFA), Warburg-subtype and survival: results from a large prospective series of colorectal cancer patients. Cancer & Metabolism, 12(1), Article 21. https://doi.org/10.1186/s40170-024-00349-z
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  • Querido, N. R., Bours, M. J. L., Brecheisen, R., Valkenburg-van Iersel, L., Breukink, S. O., Janssen-Heijnen, M. L. G., Keulen, E. T. P., Konsten, J. L. M., de Vos-Geelen, J., Weijenberg, M. P., & Simons, C. C. J. M. (2024). Validation of an automated segmentation method for body composition analysis in colorectal cancer patients using diagnostic abdominal computed tomography images. Clinical Nutrition ESPEN, 63, 659-667. https://doi.org/10.1016/j.clnesp.2024.07.1054
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  • Jenniskens, J. C. A., Offermans, K., Samarska, I., Fazzi, G. E., Simons, C. C. J. M., Smits, K. M., Schouten, L. J., Weijenberg, M. P., van den Brandt, P. A., & Grabsch, H. I. (2021). Validity and Reproducibility of Immunohistochemical Scoring by Trained Non-Pathologists on Tissue Microarrays. Cancer Epidemiology Biomarkers & Prevention, 30(10), 1867-1874. https://doi.org/10.1158/1055-9965.EPI-21-0295
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  • Offermans, K., Jenniskens, J. C., Simons, C. C., Samarska, I., Fazzi, G. E., Smits, K. M., Schouten, L. J., Weijenberg, M. P., Grabsch, H. I., & van den Brandt, P. A. (2024). Association between long-term energy balance-related factors and survival in colorectal cancer overall and by metabolic Warburg-subtypes. Cancer Epidemiology Biomarkers & Prevention, 33(10), 1356-1367. https://doi.org/10.1158/1055-9965.EPI-24-0199
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  • Simons, C. C. J. M., Offermans, N. S. M., Stoll, M., van den Brandt, P. A., & Weijenberg, M. P. (2022). Empirical Investigation of Genomic Clusters Associated with Height and the Risk of Postmenopausal Breast and Colorectal Cancer in the Netherlands Cohort Study. American Journal of Epidemiology, 191(3), 413-429. https://doi.org/10.1093/aje/kwab259
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Recent publications
  • Reitsam, N. G., Offermans, K., Simons, C. C. J. M., Grosser, B., Zimmermann, J., Grabsch, H. I., Märkl, B., & van den Brandt, P. A. (2025). Prognostic and Predictive Value of SARIFA-status Within Molecular Subgroups of Colorectal Cancer: Insights From the Netherlands Cohort Study. American Journal of Surgical Pathology. Advance online publication. https://doi.org/10.1097/PAS.0000000000002408
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  • Offermans, K., Jenniskens, J. C. A., Simons, C. C. J. M., Samarska, I., Fazzi, G. E., Smits, K. M., Schouten, L. J., Weijenberg, M. P., Grabsch, H., & van den Brandt, P. A. (2025). Association between individual Warburg-related proteins and prognosis in colorectal cancer. Journal of Pathology Clinical Research, 11(2), Article e70016. https://doi.org/10.1002/2056-4538.70016
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  • Offermans, K., Jenniskens, J. C., Simons, C. C., Samarska, I., Fazzi, G. E., Smits, K. M., Schouten, L. J., Weijenberg, M. P., Grabsch, H. I., & van den Brandt, P. A. (2024). Association between long-term energy balance-related factors and survival in colorectal cancer overall and by metabolic Warburg-subtypes. Cancer Epidemiology Biomarkers & Prevention, 33(10), 1356-1367. https://doi.org/10.1158/1055-9965.EPI-24-0199
    More information about this publication
  • Le, H., Simons, C. C. J. M., & van den Brandt, P. A. (2024). The association between height and risk of lung cancer subtypes in men and women in the Netherlands Cohort Study. Cancer Epidemiology, 92, Article 102613. https://doi.org/10.1016/j.canep.2024.102613
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  • Querido, N. R., Bours, M. J. L., Brecheisen, R., Valkenburg-van Iersel, L., Breukink, S. O., Janssen-Heijnen, M. L. G., Keulen, E. T. P., Konsten, J. L. M., de Vos-Geelen, J., Weijenberg, M. P., & Simons, C. C. J. M. (2024). Validation of an automated segmentation method for body composition analysis in colorectal cancer patients using diagnostic abdominal computed tomography images. Clinical Nutrition ESPEN, 63, 659-667. https://doi.org/10.1016/j.clnesp.2024.07.1054
    More information about this publication
  • Offermans, K., Reitsam, N. G., Simons, C. C. J. M., Grosser, B., Zimmermann, J., Grabsch, H. I., Märkl, B., & van den Brandt, P. A. (2024). The relationship between Stroma AReactive Invasion Front Areas (SARIFA), Warburg-subtype and survival: results from a large prospective series of colorectal cancer patients. Cancer & Metabolism, 12(1), Article 21. https://doi.org/10.1186/s40170-024-00349-z
    More information about this publication
  • Offermans, K., Jenniskens, J. C. A., Simons, C. C. J. M., Samarska, I., Fazzi, G. E., Smits, K. M., Schouten, L. J., Weijenberg, M. P., Grabsch, H. I., & van den Brandt, P. A. (2023). Association between adjuvant therapy and survival in colorectal cancer patients according to metabolic Warburg-subtypes. Journal of Cancer Research and Clinical Oncology, 149(9), 6271-6282. https://doi.org/10.1007/s00432-023-04581-w
    More information about this publication
  • Offermans, K., Jenniskens, J. C. A., Simons, C. C. J. M., Samarska, I., Fazzi, G. E., van der Meer, J. R. M., Smits, K. M., Schouten, L. J., Weijenberg, M. P., Grabsch, H. I., & van den Brandt, P. A. (2023). Association between mutational subgroups, Warburg-subtypes, and survival in patients with colorectal cancer. Cancer Medicine, 12(2), 1137-1156. https://doi.org/10.1002/cam4.4968
    More information about this publication
  • Jenniskens, J. C. A., Offermans, K., Simons, C. C. J. M., Samarska, I., Fazzi, G. E., van der Meer, J. R. M., Smits, K. M., Schouten, L. J., Weijenberg, M. P., Grabsch, H. I., & Brandt, P. A. V. D. (2022). Energy balance-related factors in childhood and adolescence and risk of colorectal cancer based on KRAS, PIK3CA, and BRAF mutations and MMR status. Molecular Carcinogenesis, 61(12), 1099-1115. https://doi.org/10.1002/mc.23459
    More information about this publication
  • Jenniskens, J. C. A., Offermans, K., Simons, C. C. J. M., Samarska, I., Fazzi, G. E., van der Meer, J. R. M., Smits, K. M., Schouten, L. J., Weijenberg, M. P., Grabsch, H. I., & van den Brandt, P. A. (2022). Energy balance-related factors and risk of colorectal cancer based on KRAS, PIK3CA, and BRAF mutations and MMR status. Journal of Cancer Research and Clinical Oncology, 148(10), 2723-2742. https://doi.org/10.1007/s00432-022-04019-9
    More information about this publication
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