Dr R.J. Vreeken

Flinders, B., Huizing, L., Singh, B., Lim, H.-K., van Heerden, M., Cuyckens, F., Heeren, R. M. A., & Vreeken, R. J. (2025). Investigation into Drug-Induced Liver Damage Using Multimodal Mass Spectrometry Imaging. Journal of the American Society for Mass Spectrometry, 36(2), 265-276. https://doi.org/10.1021/jasms.4c00313

Vezzali, E., Becker, M., Romero-Palomo, F., van Heerden, M., Chipeaux, C., Hamm, G., Bangari, D. S., Lemarchand, T., Lenz, B., Munteanu, B., Singh, B., Thuilliez, C., Yun, S.-W., Smith, A., & Vreeken, R. (2025). European Society of Toxicologic Pathology-Pathology 2.0 Mass Spectrometry Imaging Special Interest Group: Mass Spectrometry Imaging in Diagnostic and Toxicologic Pathology for Label-Free Detection of Molecules-From Basics to Practical Applications. Toxicologic Pathology. Advance online publication. https://doi.org/10.1177/01926233241311269

Maris, E., Jahouh, F., Allaerts, K., & Vreeken, R. (2024). Development of a sequential laser microdissection tissue cuts workflow for the spatial and quantitative analysis of drugs in fresh frozen tissue sections. PLOS ONE, 19(12), Article e0312542. https://doi.org/10.1371/journal.pone.0312542

Rousel, J., Nadaban, A., Saghari, M., Pagan, L., Zhuparris, A., Theelen, B., Gambrah, T., van der Wall, H. E. C., Vreeken, R. J., Feiss, G. L., Niemeyer-van der Kolk, T., Burggraaf, J., van Doorn, M. B. A., Bouwstra, J. A., & Rissmann, R. (2024). Lesional skin of seborrheic dermatitis patients is characterized by skin barrier dysfunction and correlating alterations in the stratum corneum ceramide composition. Experimental dermatology, 33(1), Article e14952. https://doi.org/10.1111/exd.14952

Huizing, L., Chen, L., Roeth, A. A., Heij, L. R., Flinders, B., Bouwense, S. A. W., Balluff, B., Neumann, U. P., Heeren, R. M. A., Damink, S. W. M. O., Vreeken, R. J., & Schaap, F. G. (2023). Tumor ratio of unsaturated to saturated sulfatide species is associated with disease-free survival in intrahepatic cholangiocarcinoma. Cellular oncology, 46(3), 629-642. https://doi.org/10.1007/s13402-022-00766-6

Lamont, L., Hadavi, D., Bowman, A. P., Flinders, B., Cooper-Shepherd, D., Palmer, M., Jordens, J., Mengerink, Y., Honing, M., Langridge, J., Siegel, T. P., Vreeken, R. J., & Heeren, R. M. A. (2023). High-Resolution Ion Mobility Spectrometry Mass Spectrometry for Isomeric Separation of Prostanoids after Girard's reagent T Derivatization. Rapid Communications in Mass Spectrometry, 37(5), Article e9439. https://doi.org/10.1002/rcm.9439

Lamont, L., Hadavi, D., Viehmann, B., Flinders, B., Heeren, R. M. A., Vreeken, R. J., & Porta Siegel, T. (2021). Quantitative mass spectrometry imaging of drugs and metabolites: a multiplatform comparison. Analytical and Bioanalytical Chemistry, 413(10), 2779-2791. https://doi.org/10.1007/s00216-021-03210-0

Huizing, L. R. S., McDuffie, J., Cuyckens, F., van Heerden, M., Koudriakova, T., Heeren, R. M. A., & Vreeken, R. J. (2021). Quantitative Mass Spectrometry Imaging to Study Drug Distribution in the Intestine Following Oral Dosing. Analytical Chemistry, 93(4), 2144-2151. https://doi.org/10.1021/acs.analchem.0c03956

Boer, D. E. C., van Smeden, J., Al-Khakany, H., Melnik, E., van Dijk, R., Absalah, S., Vreeken, R. J., Haenen, C. C. P., Lavrijsen, A. P. M., Overkleeft, H. S., Aerts, J. M. F. G., & Bouwstra, J. A. (2020). Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1865(6), Article 158673. https://doi.org/10.1016/j.bbalip.2020.158673

de Maar, J. S., Sofias, A. M., Siegel, T. P., Vreeken, R. J., Moonen, C., Bos, C., & Deckers, R. (2020). Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment. Theranostics, 10(4), 1884-1909. https://doi.org/10.7150/thno.38625