Dr P.M.G. Niessen

van den Eynde, M. D. G., Houben, A. J. H. M., Scheijen, J. L. J. M., Linkens, A. M. A., Niessen, P. M., Simons, N., Hanssen, N. M. J., Kusters, Y. H. A. M., Eussen, S. J. M. P., Miyata, T., Stehouwer, C. D. A., & Schalkwijk, C. G. (2023). Pyridoxamine reduces methylglyoxal and markers of glycation and endothelial dysfunction, but does not improve insulin sensitivity or vascular function in abdominally obese individuals: A randomized double-blind placebo-controlled trial. Diabetes Obesity & Metabolism, 25(5), 1280-1291. https://doi.org/10.1111/dom.14977

Linkens, A. M. A., van Best, N., Niessen, P. M., Wijckmans, N. E. G., de Goei, E. E. C., Scheijen, J. L. J. M., van Dongen, M. C. J. M., van Gool, C. C. J. A. W., de Vos, W. M., Houben, A. J. H. M., Stehouwer, C. D. A., Eussen, S. J. M. P., Penders, J., & Schalkwijk, C. G. (2022). A 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals: The deAGEing Trial. International journal of molecular sciences, 23(10), Article 5328. https://doi.org/10.3390/ijms23105328

Linkens, A. M. A., Houben, A. J., Niessen, P. M., Wijckmans, N., de Goei, E., Van den Eynde, M. D. G., Scheijen, J. L. J. M., Waarenburg, M., Mari, A., Berendschot, T. T. J. M., Streese, L., Hanssen, H., van Dongen, M. C. J. M., van Gool, C., Stehouwer, C. D. A., Eussen, S. J. P. M., & Schalkwijk, C. (2022). A 4-week high-AGE diet does not impair glucose metabolism and vascular function in obese individuals. JCI INSIGHT, 7(6), Article e156950. https://doi.org/10.1172/jci.insight.156950

Brouwers, O., Yu, L., Niessen, P., Slenter, J., Jaspers, K., Wagenaar, A., Post, M., Miyata, T., Backes, W., Stehouwer, C., Huijberts, M., & Schalkwijk, C. (2016). Glyoxalase-1 overexpression partially prevents diabetes-induced impaired arteriogenesis in a rat hindlimb ligation model. Glycoconjugate Journal, 33(4), 627-630. https://doi.org/10.1007/s10719-016-9681-3

Brouwers, O., Niessen, P. M. G., Miyata, T., Ostergaard, J. A., Flyvbjerg, A., Peutz-Kootstra, C. J., Sieber, J., Mundel, P. H., Brownlee, M., Janssen, B. J. A., De Mey, J. G. R., Stehouwer, C. D. A., & Schalkwijk, C. G. (2014). Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes. Diabetologia, 57(1), 224-235. https://doi.org/10.1007/s00125-013-3088-5

Brouwers, O., de Vos-Houben, J. M., Niessen, P. M., Miyata, T., van Nieuwenhoven, F., Janssen, B. J., Hageman, G., Stehouwer, C. D., & Schalkwijk, C. G. (2013). Mild oxidative damage in the diabetic rat heart is attenuated by glyoxalase-1 overexpression. International Journal of Molecular Sciences, 14(8), 15724-15739. https://doi.org/10.3390/ijms140815724

Gaens, K. H. J., Niessen, P. M. G., Rensen, S. S., Buurman, W. A., Greve, J. W. M., Driessen, A., Wolfs, M. G. M., Hofker, M. H., Bloemen, J. G., Dejong, C. H., Stehouwer, C. D. A., & Schalkwijk, C. G. (2012). Endogenous formation of Nε(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis. Journal of Hepatology, 56(3), 647-655. https://doi.org/10.1016/j.jhep.2011.07.028

Brouwers, O., Niessen, P. M., Ferreira, I., Miyata, T., Scheffer, P. G., Teerlink, T., Schrauwen, P., Brownlee, M., Stehouwer, C. D. A., & Schalkwijk, C. G. (2011). Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats. Journal of Biological Chemistry, 286(2), 1374-1380. https://doi.org/10.1074/jbc.M110.144097

Brouwers, O., Niessen, P. M., Haenen, G. R. M. M., Miyata, T., Brownlee, M., Stehouwer, C. D. A., de Mey, J. G. R., & Schalkwijk, C. G. (2010). Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress. Diabetologia, 53(5), 989-1000. https://doi.org/10.1007/s00125-010-1677-0

Rensen, S., Niessen, P. M., van Deursen, J. M., Janssen, B. J., Heijman, E., Hermeling, E., Meens, M. J. P. M. T., Lie, N., Gijbels, M. J., Strijkers, G. J., Doevendans, P. A., Hofker, M. H., de Mey, J. G., & van Eys, G. J. (2008). Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice. Circulation, 118(8), 828-36. https://doi.org/10.1161/CIRCULATIONAHA.107.743690