PhD Conferral Mrs. Suzan M.W. Wetzels, MSc. - Double doctorate degree UM-TUL-UHasselt
Supervisors: prof.dr. C.G. Schalkwijk, prof.dr. J.J.A. Hendriks, UHasselt
Co-supervisors: dr. K. Wouters, dr. T. van Mierlo, UHasselt
Keywords: saccharified proteins, multiple sclerosis, immune system
“Advanced glycation endproducts in multiple sclerosis”
This thesis investigates the role of saccharified proteins in multiple sclerosis (MS). In MS, the shell of the nerves in the brain is attacked by the immune system. Saccharified proteins can activate specific cells of the immune system. Our research shows that MS patients have high levels of saccharified proteins in their brains. This result has been confirmed with the use of a mouse model. It has also been shown that the consumption of a diet rich in saccharified proteins causes an accumulation of these saccharified proteins in the brain. The effect of lowering saccharified proteins will need to be investigated further.