PhD defence Julian Mevenkamp

Keywords: MRS, Metabolic Imaging, Diabetes, NAD

"From Molecules to Metabolism: Methodological Innovations in MRS for Assessing NAD, Lipid Composition and Glycogen"

This thesis explores how advanced Magnetic Resonance Spectroscopy (MRS) techniques can be used to study metabolism in human muscle and liver without the need for invasive procedures. The research focuses on developing and improving MRS methods to more accurately measure key molecules involved in energy metabolism, such as NAD⁺/NADH, glycogen, and lipids. These metabolites play essential roles in how the body regulates and stores energy and are often altered in metabolic conditions like diabetes or fatty liver disease. By developing new acquisition and analysis strategies, this work enhances the ability to measure these molecules in humans and provides a foundation for studying metabolic flexibility and mitochondrial function in health and disease in clinical research.

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