PhD Conferral Daniël J.L. van Twist, MSc.

“The renin-angiotensin system in the hypertensive kidney; clinical studies in patients with essential hypertension, fibromuscular dysplasia, and the atherosclerotic renal artery stenosis”

Keywords: hypertension, renin-angiotensin system, fibromuscular dysplasia, atherosclerotic renal artery stenosis

The renin-angiotensin system is one of the most important systems for regulating blood pressure. Various signal compounds (angiotensins) play a crucial role in this system. This dissertation examined the stimulation and blockage of several angiotensins in the kidneys of hypertensive patients. It also examined the difference between patients with and without narrowing of the renal artery due to atherosclerosis or fibromuscular dysplasia. The results of this study improve our understanding of the mechanisms that contribute to high blood pressure and may help us develop improved treatment options for patients suffering from hypertension.