Dr Esther Phielix (E.)

op den Kamp-bruls, Y. M. H., op den Kamp, Y. J. M., Veeraiah, P., Perez, R. Z., Phielix, E., Havekes, B., Schaart, G., Kornips, E., Berendsen, B. R. B., Virmani, A., Wildberger, J. E., Houtkooper, R. H., Hesselink, M. K. C., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2025). Carnitine supplementation improves insulin sensitivity and skeletal muscle acetylcarnitine formation in patients with type 2 diabetes. Diabetes Obesity & Metabolism, 27(5), 2864-2877. Advance online publication. https://doi.org/10.1111/dom.16298

Pesta, D., Anadol-Schmitz, E., Sarabhai, T., op den Kamp, Y., Gancheva, S., Trinks, N., Zaharia, O.-P., Mastrototaro, L., Lyu, K., Habets, I., op den Kamp-bruls, Y. M. H., Dewidar, B., Weiss, J., Schrauwen-Hinderling, V., Zhang, D., Gaspar, R. C., Strassburger, K., Kupriyanova, Y., Al-Hasani, H., ... Roden, M. (2025). Determinants of increased muscle insulin sensitivity of exercise-trained versus sedentary normal weight and overweight individuals. Science advances, 11(1), Article eadr8849. https://doi.org/10.1126/sciadv.adr8849

Parker, V. E. R., Robertson, D., Erazo-Tapia, E., Havekes, B., Phielix, E., de Ligt, M., Roumans, K. H. M., Mevenkamp, J., Sjoberg, F., Schrauwen-Hinderling, V. B., Johansson, E., Chang, Y.-T., Esterline, R., Smith, K., Wilkinson, D. J., Hansen, L., Johansson, L., Ambery, P., Jermutus, L., & Schrauwen, P. (2023). Cotadutide promotes glycogenolysis in people with overweight or obesity diagnosed with type 2 diabetes. Nature Metabolism, 5(12), 2086–2093. https://doi.org/10.1038/s42255-023-00938-0

de Wit-Verheggen, V. H. W., Vanweert, F., Raiko, J., Liénard, V., Schaart, G., Gemmink, A., Nascimento, E. B. M., Hesselink, M. K. C., Wildberger, J. E., Wierts, R., Joris, P. J., Haas, J., Montaigne, D., Staels, B., Phielix, E., Schrauwen, P., Schrauwen-Hinderling, V. B., & van de Weijer, T. (2023). The tissue-specific metabolic effects of the PPARa agonist ciprofibrate in insulin-resistant male individuals: a double-blind, randomized, placebo-controlled crossover study. Obesity, 31(10), 2493-2504. https://doi.org/10.1002/oby.23874

Veelen, A., Andriessen, C., Op den Kamp, Y., Erazo-Tapia, E., de Ligt, M., Mevenkamp, J., Jörgensen, J. A., Moonen-Kornips, E., Schaart, G., Esterline, R., Havekes, B., Oscarsson, J., Schrauwen-Hinderling, V. B., Phielix, E., & Schrauwen, P. (2023). Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on substrate metabolism in prediabetic insulin resistant individuals: A randomized, double-blind crossover trial. Metabolism-Clinical and Experimental, 140(1), Article 155396. https://doi.org/10.1016/j.metabol.2022.155396

Op den Kamp, Y. J. M., Gemmink, A., de Ligt, M., Dautzenberg, B., Kornips, E., Jorgensen, J. A., Schaart, G., Esterline, R., Pava, D. A., Hoeks, J., Schrauwen-Hinderling, V. B., Kersten, S., Havekes, B., Koves, T. R., Muoio, D. M., Hesselink, M. K. C., Oscarsson, J., Phielix, E., & Schrauwen, P. (2022). Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism. Molecular Metabolism, 66, Article 101620. https://doi.org/10.1016/j.molmet.2022.101620

Vanweert, F., Schrauwen, P., & Phielix, E. (2022). Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes. Nutrition & Diabetes, 12(1), Article 35. https://doi.org/10.1038/s41387-022-00213-3

Vanweert, F., Neinast, M., Tapia, E. E., van de Weijer, T., Hoeks, J., Schrauwen-Hinderling, V. B., Blair, M. C., Bornstein, M. R., Hesselink, M. K. C., Schrauwen, P., Arany, Z., & Phielix, E. (2022). A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes. Nature Communications, 13(1), Article 3508. https://doi.org/10.1038/s41467-022-31249-9

Jelenik, T., Kodde, A., Pesta, D., Phielix, E., Oosting, A., Rohbeck, E., Dewidar, B., Mastrototaro, L., Trenkamp, S., Keijer, J., van der Beek, E. M., & Roden, M. (2022). Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming. Pharmacological Research, 179, Article 106193. https://doi.org/10.1016/j.phrs.2022.106193

Remie, C. M. E., Janssens, G. E., Bilet, L., Van Weeghel, M., Duvivier, B. M. F. M., De Wit, V. H. W., Connell, N. J., Jorgensen, J. A., Schomakers, B. V., Schrauwen-Hinderling, V. B., Hoeks, J., Hesselink, M. K. C., Phielix, E., Houtkooper, R. H., & Schrauwen, P. (2021). Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women. Diabetologia, 64(12), 2817-2828. https://doi.org/10.1007/s00125-021-05558-5