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IMS infrastructure

Working with M4I infrastructure

M4I Division of Imaging Mass Spectrometry has the following capabilities:

The IMS CORE lab provides service, training, support and access to the MS imaging and proteomic technologies

Mass Spectrometry

  • 9.4T MALDI/ESI SolariX Fourier Transform Ion Cyclotron Resonance imaging mass spectrometer
  • 7T LTQ-FTICR system for ambient ionisation and imaging
  • LAESI DP-1000 ambient imaging system of Protea Biosciences
  • Bruker Ultraflex III ToF/ToF MALDI molecular imager with an IonPix Camera
  • A Bruker RapiFlex TissueTyper
  • A MS/MS enabled Bruker Rapiflex TissueTyper
  • A Bruker MALDI-ToF Biotyper for microbial screening

  • Physical Electronics NanoTof V Tandem MS SIMS system for high resolution SIMS equipped with a Bismuth, C60 and Argon Cluster sources
  • A Physical Electronics TRIFT II for SIMS imaging with a Gold source
  • TRIFT II based mass microscope for direct ion imaging with MALDI and C60-SIMS
  • Waters 8K MALDI/ESI Synapt G2Si system for ion mobility enabled high resolution molecular imaging
  • Waters 32K MALDI/ESI Synapt G2Si system for ion mobility enabled high resolution molecular imaging and MRM
  • Waters MALDI Synapt HDMS system for conformational molecular imaging
  • A Waters Xevo q-ToF system equipped with a DESI source for ambient ionization based imaging

  • A Waters Xevo-q-ToF system equipped with a REIMS source for the development of intraoperative diagnostics
  • A Waters HEPA filtered Xevo q-ToF systems system equipped with a REIMS source for research on intraoperative diagnostics
  • A Waters TQS-micro triple quad with DESI-MRM capabilities.
  • A Thermo Scientific q-Exactive HF system with a nano-LC system
  • A Thermo Scientific Orbitrap Elite with a Spectroglyph MALDI imaging source for high resolution imaging MS
  • A SimulToF MALDI Linear ToF imaging system
  • An LCT q-ToF system modified for native MS and fitted with a high molecular weight IonPix Camera

Sample preparation

A fully equipped sample preparation facility, including cryosectioning, staining, analytical microscopes, matrix deposition and coating devices such as:

  • Advion Triversa Nanomate system

  • Several matrix deposition systems. ImagePrep, SunCollect and HTX sprayer
  • 2 Cryo-microtomes for imaging MS
  • Mirax histology scanner
  • Leica optical research microscope with UV fluorescence imaging module

  • ChIP spotting robot for LC-MALDI
  • Virtual laboratory based image processing and analysis tools, including tissue classification and correlation software and protein data basing tools
  • Large scale data storage and cluster computing facilities

Access to our facilities

Requests to access our Imaging Mass Spectrometry facilities at M4I can be specified using the 'Access to facilities'-contact form. The lab manager of the requested facility will evaluate your request.