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Dr Gert Schaart (G.)

Key publications
  • Timmers, S., de Ligt, M., Phielix, E., van de Weijer, T., Hansen, J., Moonen-Kornips, E., Schaart, G., Kunz, I., Hesselink, M. K. C., Schrauwen-Hinderling, V. B., & Schrauwen, P. (2016). Resveratrol as Add-on Therapy in Subjects With Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Care, 39(12), 2211-2217. https://doi.org/10.2337/dc16-0499
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  • van Bree, B. W. J., Lenaers, E., Nabben, M., Briede, J. J., Jorgensen, J. A., Schaart, G., Schrauwen, P., Hoeks, J., & Hesselink, M. K. C. (2016). A genistein-enriched diet neither improves skeletal muscle oxidative capacity nor prevents the transition towards advanced insulin resistance in ZDF rats. Scientific Reports, 6, Article 22854. https://doi.org/10.1038/srep22854
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  • Jiang, J., Briede, J. J., Jennen, D. G. J., Van Summeren, A., Saritas-Brauers, K., Schaart, G., Kleinjans, J. C. S., & de Kok, T. M. C. M. (2015). Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicology Letters, 234(2), 139-150. https://doi.org/10.1016/j.toxlet.2015.02.012
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  • Dijk, W., Heine, M., Vergnes, L., Boon, M. R., Schaart, G., Hesselink, M., Reue, K., van Marken Lichtenbelt, W., Olivecrona, G., Rensen, P. C., Heeren, J., & Kersten, S. (2015). ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure. Elife, 4(OCTOBER2015), Article e08428. https://doi.org/10.7554/eLife.08428
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  • van der Lans, A. A. J., Boon, M. R., Haks, M. C., Quinten, E., Schaart, G., Ottenhoff, T. H., & van Marken Lichtenbelt, W. (2015). Cold acclimation affects immune composition in skeletal muscle of healthy lean subjects. Physiological Reports, 3(7), Article e12394. https://doi.org/10.14814/phy2.12394
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  • Broeders, E. P., Nascimento, E. B. M., Havekes, B., Brans, B., Roumans, K. H. M., Tailleux, A., Schaart, G., Kouach, M., Charton, J., Deprez, B., Bouvy, N. D., Mottaghy, F., Staels, B., van Marken Lichtenbelt, W., & Schrauwen, P. (2015). The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity. Cell Metabolism, 22(3), 418-426. https://doi.org/10.1016/j.cmet.2015.07.002
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  • Hanssen, M. J., Hoeks, J., Brans, B., van der Lans, A. A., Schaart, G., van den Driessche, J. J., Jorgensen, J. A., Boekschoten, M. V., Hesselink, M. K., Havekes, B., Kersten, S., Mottaghy, F. M., van Marken Lichtenbelt, W. D., & Schrauwen, P. (2015). Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nature Medicine, 21(8), 863-865. https://doi.org/10.1038/nm.3891
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  • Catoire, M., Alex, S., Paraskevopulos, N., Mattijssen, F., Evers - van Gogh, I., Schaart, G., Jeppesen, J., Kneppers, A., Mensink, M., Voshol, P. J., Olivecrona, G., Tan, N. S., Hesselink, M. K., Berbee, J. F., Rensen, P. C., Kalkhoven, E., Schrauwen, P., & Kersten, S. (2014). Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise. Proceedings of the National Academy of Sciences of the United States of America, 111(11), E1043-E1052. https://doi.org/10.1073/pnas.1400889111
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  • Woldt, E., Sebti, Y., Solt, L. A., Duhem, C., Lancel, S., Eeckhoute, J., Hesselink, M. K. C., Paquet, C., Delhaye, S., Shin, Y., Kamenecka, T. M., Schaart, G., Lefebvre, P., Neviere, R., Burris, T. P., Schrauwen, P., Staels, B., & Duez, H. (2013). Rev-erb-alpha modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy. Nature Medicine, 19(8), 1039-1046. https://doi.org/10.1038/nm.3213
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  • Smeele, K. M., Eerbeek, O., Schaart, G., Koeman, A., Bezemer, R., Nelson, J. K., Ince, C., Nederlof, R., Boek, M., Laakso, M., Haan, A., Drost, M. R., Hollmann, M. W., & Zuurbier, C. J. (2012). Reduced hexokinase II impairs muscle function 2 wk after ischemia-reperfusion through increased cell necrosis and fibrosis. Journal of Applied Physiology, 113(4), 608-618. https://doi.org/10.1152/japplphysiol.01494.2011
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Recent publications
  • op den Kamp-bruls, Y. M. H., op den Kamp, Y. J. M., Veeraiah, P., Perez, R. Z., Phielix, E., Havekes, B., Schaart, G., Kornips, E., Berendsen, B. R. B., Virmani, A., Wildberger, J. E., Houtkooper, R. H., Hesselink, M. K. C., Schrauwen, P., & Schrauwen-Hinderling, V. B. (2025). Carnitine supplementation improves insulin sensitivity and skeletal muscle acetylcarnitine formation in patients with type 2 diabetes. Diabetes Obesity & Metabolism, 27(5), 2864-2877. https://doi.org/10.1111/dom.16298
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  • Xia, Y., Caputo, M., Andersson, E., Asiedu, B., Zhang, J., Hou, W., Amrutkar, M., Cansby, E., Gul, N., Gemmink, A., Myers, C., Aghajan, M., Booten, S., Hoy, A. J., Härtlova, A., Lindahl, P., Ståhlberg, A., Schaart, G., Hesselink, M. K. C., ... Mahlapuu, M. (2025). Therapeutic Potential of STE20-Type Kinase STK25 Inhibition for the Prevention and Treatment of Metabolically Induced Hepatocellular Carcinoma. CMGH Cellular and Molecular Gastroenterology and Hepatology, 19(7), Article 101485. https://doi.org/10.1016/j.jcmgh.2025.101485
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  • Sellers, A. J., van Beek, S. M. M., Hashim, D., Baak, R., Pallubinsky, H., Moonen-Kornips, E., Schaart, G., Gemmink, A., Jorgensen, J. A., van de Weijer, T., Kalkhoven, E., Hooiveld, G. J., Kersten, S., Hesselink, M. K. C., Schrauwen, P., Hoeks, J., & Lichtenbelt, W. D. V. M. (2024). Cold acclimation with shivering improves metabolic health in adults with overweight or obesity. Nature Metabolism, 6(12), 2246-2253. Article 1516. https://doi.org/10.1038/s42255-024-01172-y
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  • Chen, S., Wang, Q., Bakker, D., Hu, X., Zhang, L., van der Made, I., Tebbens, A. M., Kovacshazi, C., Giricz, Z., Brenner, G. B., Ferdinandy, P., Schaart, G., Gemmink, A., Hesselink, M. K. C., Rivaud, M. R., Pieper, M. P., Hollmann, M. W., Weber, N. C., Balligand, J.-L., ... Zuurbier, C. J. (2024). Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2. Basic Research in Cardiology, 119(5), 751-772. https://doi.org/10.1007/s00395-024-01067-9
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  • de Wit-Verheggen, V. H. W., Vanweert, F., Raiko, J., Liénard, V., Schaart, G., Gemmink, A., Nascimento, E. B. M., Hesselink, M. K. C., Wildberger, J. E., Wierts, R., Joris, P. J., Haas, J., Montaigne, D., Staels, B., Phielix, E., Schrauwen, P., Schrauwen-Hinderling, V. B., & van de Weijer, T. (2023). The tissue-specific metabolic effects of the PPARa agonist ciprofibrate in insulin-resistant male individuals: a double-blind, randomized, placebo-controlled crossover study. Obesity, 31(10), 2493-2504. https://doi.org/10.1002/oby.23874
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  • Gemmink, A., Daemen, S., Wefers, J., Hansen, J., van Moorsel, D., Astuti, P., Jorgensen, J. A., Kornips, E., Schaart, G., Hoeks, J., Schrauwen, P., & Hesselink, M. K. C. (2023). Twenty-four hour rhythmicity in mitochondrial network connectivity and mitochondrial respiration; a study in human skeletal muscle biopsies of young lean and older individuals with obesity. Molecular Metabolism, 72(1), Article 101727. https://doi.org/10.1016/j.molmet.2023.101727
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  • de Wit-Verheggen, V. H. W., Schrauwen-Hinderling, V. B., Brouwers, K., Joergensen, J. A., Schaart, G., Gemmink, A., Nascimento, E. B. M., Hesselink, M. K. C., Wildberger, J. E., Segers, P., Montaigne, D., Staels, B., Schrauwen, P., Lindeboom, L., Hoeks, J., & van de Weijer, T. (2023). PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans. Scientific Reports, 13(1), Article 8346. https://doi.org/10.1038/s41598-023-35041-7
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  • Veelen, A., Andriessen, C., Op den Kamp, Y., Erazo-Tapia, E., de Ligt, M., Mevenkamp, J., Jörgensen, J. A., Moonen-Kornips, E., Schaart, G., Esterline, R., Havekes, B., Oscarsson, J., Schrauwen-Hinderling, V. B., Phielix, E., & Schrauwen, P. (2023). Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on substrate metabolism in prediabetic insulin resistant individuals: A randomized, double-blind crossover trial. Metabolism-Clinical and Experimental, 140(1), Article 155396. https://doi.org/10.1016/j.metabol.2022.155396
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  • van Beek, S. M. M., Bruls, Y. M. H., Vanweert, F., Fealy, C. E., Connell, N. J., Schaart, G., Moonen-Kornips, E., Jorgensen, J. A., Vaz, F. M., Smeets, E. T. H. C., Joris, P. J., Gemmink, A., Houtkooper, R. H., Hesselink, M. K. C., Bengtsson, T., Havekes, B., Schrauwen, P., & Hoeks, J. (2023). Effect of beta 2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial. Nature Communications, 14(1), Article 173. https://doi.org/10.1038/s41467-023-35798-5
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  • Op den Kamp, Y. J. M., Gemmink, A., de Ligt, M., Dautzenberg, B., Kornips, E., Jorgensen, J. A., Schaart, G., Esterline, R., Pava, D. A., Hoeks, J., Schrauwen-Hinderling, V. B., Kersten, S., Havekes, B., Koves, T. R., Muoio, D. M., Hesselink, M. K. C., Oscarsson, J., Phielix, E., & Schrauwen, P. (2022). Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism. Molecular Metabolism, 66, Article 101620. https://doi.org/10.1016/j.molmet.2022.101620
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