Jalal Cherkaoui (J.)

TrackAF – Mechanistic Modeling of Atrial Fibrillation (2026–Present)
Maastricht University – CARIM | Horizon Europe MSCA Doctoral Network

Development of three-dimensional mechanistic models of atrial fibrillation integrating genomic and multi-omics data to characterize patient-specific arrhythmogenic substrates. The research aims to investigate atrial remodeling, identify clinically relevant patient phenotypes, and explore computational approaches to predict responses to therapeutic interventions, including catheter ablation and antiarrhythmic drugs.

Simulation-Based Modeling of Pediatric Aortic Valve Reconstruction (2024–2026)
Long Island University – Dassault Systèmes Center of Excellence in Life Sciences

Development of finite element models to investigate the mechanical behavior of oversized pericardial leaflets implanted during pediatric aortic valve reconstruction. The project evaluated leaflet deformation, coaptation, and mechanical compatibility under physiological loading conditions.

Published in JTCVS Open (2026).

Personalized Computational Assessment of Drug-Induced Cardiac Arrhythmias (2024–2026)
Long Island University – Dassault Systèmes Center of Excellence in Life Sciences

Development of personalized cardiac electrophysiology models integrating genetic variants of cardiac ion channels (hERG and Nav1.5) to investigate drug-induced proarrhythmic risk. Computational simulations were used to assess the influence of genetic variability on the electrophysiological response to antiarrhythmic medications.

Published in Frontiers in Physiology (2026).

Development of a Virtual Hepatic Lobule for Drug-Induced Liver Injury Prediction (2023–2024)
Long Island University – Dassault Systèmes Center of Excellence in Life Sciences

Development and calibration of a multiscale computational model of acetaminophen-induced hepatotoxicity. The project integrated pharmacokinetics, hepatocyte-level injury mechanisms, and spatial liver zonation to investigate drug-induced liver damage and support computational drug safety assessment.

Published in npj Digital Medicine (2024).