R. Shiri - Sverdlov

Stoffels, L. M., Rodriguez, E. S. E., Theys, J., & Shiri-Sverdlov, R. (2026). Revisiting cholesterol metabolism in hepatocellular carcinoma: a hidden driver of systemic therapy response. ESMO Gastrointestinal Oncology, 11, Article 100284. https://doi.org/10.1016/j.esmogo.2025.100284

Westheim, A. J. F., Dubois, L. J., Prades-Sagarra, E., Chan, J., van der Wiel, A. M. A., Lieuwes, N. G., Biemans, R., Cong, Y., Houben, T., Meesters, D. M., Yaromina, A., van Dijk, M., van Bergenhenegouwen, J., van Helvoort, A., Langen, R. C. J., Penders, J., Shiri-sverdlov, R., & Theys, J. (2026). The Effect of Dietary Fiber Compositions on the Therapeutic Outcome of Combined Radio- and Immunotherapy in a Preclinical Cancer Model. Molecular Nutrition & Food Research, 70(2), Article e70370. https://doi.org/10.1002/mnfr.70370

Lu, F., Groven, R. V. M., Meesters, D. M., Bitorina, A., Poeze, M., Tang, S., van Griensven, M., Blokhuis, T. J., & Shiri-Sverdlov, R. (2025). Cathepsin D and G expression correlates with human fracture healing phases and specific neutrophil N1 and N2 phenotypes. Bone, 199, Article 117574. https://doi.org/10.1016/j.bone.2025.117574

Peters, L., Rakateli, L., Huchzermeier, R., Bonnin-Marquez, A., Maas, S. L., Lin, C., Jans, A., Geng, Y., Gorter, A., Gijbels, M., Rensen, S., Olinga, P., Hendrikx, T., Krawczyk, M., Brisbois, M., Jankowski, J., Bidzhekov, K., Weber, C., Biessen, E. A. L., ... van der Vorst, E. (2025). MicroRNA-26b protects against MASH development in mice and can be efficiently targeted with lipid nanoparticles. Elife, 13. https://doi.org/10.7554/eLife.97165

Vermeulen, I., Li, M., van Mourik, H., Yadati, T., Eijkel, G., Balluff, B., Godschalk, R., Temmerman, L., Biessen, E. A. L., Kulkarni, A., Theys, J., Houben, T., Cillero-Pastor, B., & Shiri-Sverdlov, R. (2025). Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis. FEBS Journal, 292(7), 1781-1797. https://doi.org/10.1111/febs.17358

Westheim, A. J. F., Dubois, L. J., Prades-Sagarra, E., van de Laak, J. G. M., van Mourik, H., Schuitmaker, L., Stoffels, L. M., Yaromina, A., van Dijk, M., van Bergenhenegouwen, J., van Helvoort, A., Langen, R. C. J., Shiri-Sverdlov, R., & Theys, J. (2025). Dietary enrichment with n-3 lc-PUFA-rich fish oil improves preclinical outcome of radiotherapy and anti-PD-L1 combination treatment. Cancer Treatment and Research Communications, 44, Article 100943. https://doi.org/10.1016/j.ctarc.2025.100943

van Mourik, H., Westheim, A., Schneider, C. V., Stoffels, L., Wieczerzak, E., Steeghs, J., Schneider, K. M., Temmerman, L., Biessen, E., Godschalk, R., Theys, J., & Shiri - Sverdlov, R. (2025). Extracellular Cathepsin B Is a potential Therapeutic Target in Hepatocellular Carcinoma. Liver International, 6(1), Article e70016. https://doi.org/10.1002/lci2.70016

Heymann, C. J. F., Mak, A. L., Holleboom, A. G., Verheij, J., Shiri-Sverdlov, R., van Mil, S. W. C., Tushuizen, M. E., Koek, G. H., & Grefhorst, A. (2024). The plasma lipidome varies with the severity of metabolic dysfunction-associated steatotic liver disease. Lipids in Health and Disease, 23(1), Article 402. https://doi.org/10.1186/s12944-024-02380-x

Li, M., Houben, T., Bitorina, A. V., Meesters, D. M., Israelsen, M., Kjærgaard, M., Koek, G. H., Hendrikx, T., Verbeek, J., Krag, A., Thiele, M., & Shiri-Sverdlov, R. (2024). Plasma cathepsin D as an early indicator of alcohol-related liver disease. JHEP Reports, 6(9), Article 101117. https://doi.org/10.1016/j.jhepr.2024.101117

Westheim, A. J. F., Stoffels, L. M., Dubois, L. J., van Bergenhenegouwen, J., van Helvoort, A., Langen, R. C. J., Shiri-Sverdlov, R., & Theys, J. (2023). The Modulatory Effects of Fatty Acids on Cancer Progression. Biomedicines, 11(2), Article 280. https://doi.org/10.3390/biomedicines11020280