CARIM 2013-2018_Case studies.pdf
(3.19 MB, PDF)
… In these times, vascular calcification was regarded as an innocent bystander in cardiovascular disease. It was considered to be the passive chemical nucleation of calcium and phosphate ions on vascular smooth muscle cell debris and therefore the end-stage of CVD. Our research in Maastricht significantly contributed to the understanding that vitamin K-dependent proteins are involved in vascular calcification which boosted our mechanistic understanding of this process and offers targets for … than six hours after stroke onset. Third, it was shown that, like with intravenous thrombolysis, effect of endovascular treatment was strongly time dependent. Besides its scientific relevance, MR CLEAN also has a huge societal impact. It has set a new stage for the treatment of acute ischemic stroke. To implement this new treatment in practice, stroke care in the Netherlands and in the rest of the world needs to be reorganised as the current system has to evolve into an effectively organised system …