Dick Sijm (T.H.M.)

Bischoff, N. S., Undas, A. K., van Herwijnen, M., Verheijen, M., Briedé, J. J., van Breda, S. G., Sijm, D. T. H. M., & de Kok, T. M. (2025). E171-induced toxicity in human iPSC-derived colon organoids: Effects on cell viability, ROS generation, DNA damage, and gene expression changes. Toxicology in Vitro, 108, Article 106105. https://doi.org/10.1016/j.tiv.2025.106105

Amstutz, V. H., Mircheva, A., Cengo, A., Dubois, L. J., Sijm, D. T. H. M., & Vrolijk, M. F. (2025). A subcellular study on reactive oxygen species generation by PFAS in HepG2 cells. Scientific Reports, 15(1), Article 21914. https://doi.org/10.1038/s41598-025-07503-7

Kourkopoulos, A., Sijm, D. T. H. M., Mircheva, A., Bastos, V. C., & Vrolijk, M. F. (2025). In vitro hazard characterization of contaminants migrating from recycled paper food contact materials. Regulatory Toxicology and Pharmacology, 159, Article 105816. https://doi.org/10.1016/j.yrtph.2025.105816

Kourkopoulos, A., Sijm, D. T. H. M., & Vrolijk, M. (2025). Migration of toxic elements from recycled paper food contact materials to food simulants: compatibility and influence of sample preparation methods. Food Quality and Safety, 9, Article fyaf002. https://doi.org/10.1093/fqsafe/fyaf002

Kourkopoulos, A., Sijm, D. T. H. M., Geerken, J., & Vrolijk, M. F. (2025). Compatibility and interference of food simulants and organic solvents with the in vitro toxicological assessment of food contact materials. Journal of Food Science, 90(2), Article e17659. https://doi.org/10.1111/1750-3841.17659

Bischoff, N. S., Bussi, M. R., Van Breda, S. G., Jolani, S., Sijm, D. T. H. M., de Kok, T. M., & Briede, J. J. (2025). Food-grade titanium dioxide exposure between age groups and in global regions: a systematic review and meta-analysis. Critical Reviews in Food Science and Nutrition. https://doi.org/10.1080/10408398.2025.2467823

Bischoff, N. S., Undas, A. K., van Bemmel, G., Briedé, J. J., van Breda, S. G., Verhoeven, J., Verbruggen, S., Venema, K., Sijm, D. T. H. M., & de Kok, T. M. (2025). Investigating the ROS Formation and Particle Behavior of Food-Grade Titanium Dioxide (E171) in the TIM-1 Dynamic Gastrointestinal Digestion Model. Nanomaterials, 15(1), Article 8. https://doi.org/10.3390/nano15010008

Amstutz, V. H., Sijm, D. T. H. M., & Vrolijk, M. F. (2024). Perfluoroalkyl substances and immunotoxicity: An in vitro structure-activity relationship study in THP-1-derived monocytes and macrophages. Chemosphere, 364, Article 143075. https://doi.org/10.1016/j.chemosphere.2024.143075

Tukker, A. M., Vrolijk, M. F., van Kleef, R. G. D. M., Sijm, D. T. H. M., & Westerink, R. H. S. (2023). Mixture effects of tetrodotoxin (TTX) and drugs targeting voltage-gated sodium channels on spontaneous neuronal activity in vitro. Toxicology Letters, 373, 53-61. https://doi.org/10.1016/j.toxlet.2022.11.005

Amstutz, V. H., Cengo, A., Gehres, F., Sijm, D. T. H. M., & Vrolijk, M. F. (2022). Investigating the cytotoxicity of per- and polyfluoroalkyl substances in HepG2 cells: a Structure-Activity Relationship approach. Toxicology, 480, Article 153312. https://doi.org/10.1016/j.tox.2022.153312