Microscopy CORE Lab
The Microscopy CORE Lab is an Open Research and Education platform in the field of microscopy and collaborates with both internal and external research groups. Internal scientists are from Maastricht University (UM) and/or the Maastricht University Medical Center+ (MUMC+) whereas external scientists typically belong to other universities, research centers and/or private companies.
Advanced Light and Electron Microscopy
The MCL provides advanced light and electron microscopy (LM & EM, respectively) imaging techniques, including confocal microscopy, long-term in vivo imaging, super-resolution stimulated emission depletion (STED) microscopy, multi-photon (intravital) microscopy, fluorescence lifetime and spectroscopy imaging. Furthermore, scanning and transmission electron microscopy (SEM & TEM, respectively), electron tomography, and correlative light- and electron microscopy (CLEM) can all be performed at our facility. The MCL enables studies at both room temperature and under cryogenic conditions.
Microscopy CORE Lab; FHML
Some of the most advanced techniques were developed in the last years in collaboration with groups of users at UM. One main collaborator was the Nanoscopy division of the M4I Institute. Cryo-LM, cryo-EM techniques, e.g. spinning disk cryo-LM, cryo-electron tomography and single particle analysis (SPA), cryo-CLEM, and focused ion beam milling (FIB)-SEM at cryogenic conditions were developed at the MCL within this collaboration. Other important collaborations with MERLN Institute and Genetics and Cell Biology Department also contribute to the continuous excellence and upgrades of our facilities.
In addition, the MCL closely collaborates with the Instrument Development Engineering & Evaluation (IDEE) department to develop and implement new sample preparation, imaging instrumentation and technologies.
Mission and Vision
The MCL specializes in advanced light microscopy, cryo-electron microscopy, and correlative light and electron microscopy using classical and cryo-methods in sample preparation and analysis. The MCL results from and operates under the CORE (Collaborative Open Research & Education) philosophy of our university. We collaborate with scientists towards their research goals in our advanced microscopy training center. We assist in the implementation of both traditional and novel technologies related to microscopy imaging. Finally, the MCL actively participates in the UM education program and collaborates with the UM community as well as with external academic and biotech partners. We organize international courses to train students and scientists in advanced (cryo-) microscopy, i.e. LM, CLEM and advanced EM methods. We prioritize education by offering individualized support, training and courses for all users, from inexperienced students to mature researchers.
C. López Iglesias
Microscopy CORE Lab
K. Knoops
Microscopy CORE Lab
J.Q. Duimel
Microscopy CORE Lab
H.J.H. Kuijpers
Microscopy CORE Lab
W.J. van de Wetering
Microscopy CORE Lab
A.W.C. van Bolhuis
Microscopy CORE Lab
C.J. Lewis
Microscopy CORE Lab