M.J. Post

My main interest is Vascular Biology, particularly fundamental processes such as vascular patterning, neovascularization, endothelial and smooth muscle cell function and restenosis. As a translational arm of the research, we develop and test novel biomaterials that are suitable for arterial grafting for bypass surgery of vascular access surgery (AV shunt), providing in situ tissue engineering. The response and in vivo remodelling of these grafts provide great insight into the role of biochemical and biomechanical cues in vascular biology.

In addition, we are engaged into early diagnosis of neovascularization by means of molecular imaging. We have identified 4 novel targets for molecular imaging that we are testing in SPECT imaging of cardiovascular models exhibiting neovascularization.

Therapeutic neovascularization will likely be dependent on effective slow release, local administration of potent biologicals. Drug release polymers are currently tested for that purpose.

Finally, I became involved in a completely different field of tissue engineering: skeletal muscle tissue engineering in order to create cultured consumption meat. This technology offers great opportunities for future meat production if culture efficiency and tissue mimicry can be achieved in a cost-effective manner.

iVALVE (PI). In this consortium we develop and test new materials for arterial grafting. It is a collaboration with TU/e, Suprapolix, SymoChem, Philips, and UMCU. We have developed an electrosensitive polymer that facilitates ingrowth, cell alignment and collagen production. We also test grafts from novel PLC-based materials in a rat aorta interposition or bypass graft model.

PENT (PI). In this consortium together with TU/e, DSM, UMUC and LUMC, we develop and tested novel agent and delivery methods to enhance neovascularization.

TeRM (PI). TeRM is a national consortium of several universities and companies with the aim to develop novel tissue engineering solutions for musculoskeletal and cardiovascular defects. Autologous cells on biomaterials are being used for this purpose. Our group tested grafts in large and small animal models of interposition grafts and AV shunts. In addition, we developed novel assays for thrombogenicity of endothelial layers and on-line non-destructive collagen synthesis. Smooth muscle cell thrombogenicity and smooth muscle cell relaxation in the setting of uremia are also being investigated

EMINENCE (coordinator/PI). This is also a national consortium focussing on early diagnosis of neovascularization using sophisticated MRI acquisition and image analysis, but also novel molecular targets and visualization with SPECT.

The Hamburger project is a philantropy financed program which aims to develop consumption meat from bovine skeletal muscle stem cells. In the spring of 2013 we plan to present the world's first labgrown hamburger.

1.         Wagenaar A, Wiegerinck RF, Heijnen VV, Post MJ. Percutaneous microembolization of the left coronary artery to model ischemic heart disease in rats. Lab Anim (NY). 2016;45:20-27

2.         Hendrikx G, Vries MH, Bauwens M, De Saint-Hubert M, Wagenaar A, Guillaume J, Boonen L, Post MJ, Mottaghy FM. Comparison of ldpi to spect perfusion imaging using (99m)tc-sestamibi and (99m)tc-pyrophosphate in a murine ischemic hind limb model of neovascularization. EJNMMI Res. 2016;6:44

3.         Hendrikx G, Bauwens M, Wierts R, Mottaghy FM, Post MJ. Left ventricular function measurements in a mouse myocardial infarction model. Comparison between 3d-echocardiography and ecg-gated spect. Nuklearmedizin. 2016;55

4.         Geenen IL, Kolk FF, Molin DG, Wagenaar A, Compeer MG, Tordoir JH, Schurink GW, De Mey JG, Post MJ. Nitric oxide resistance reduces arteriovenous fistula maturation in chronic kidney disease in rats. PLoS One. 2016;11:e0146212

5.         Vries MH, Wagenaar A, Verbruggen SE, Molin DG, Dijkgraaf I, Hackeng TH, Post MJ. Cxcl1 promotes arteriogenesis through enhanced monocyte recruitment into the peri-collateral space. Angiogenesis. 2015;18:163-171

6.         van Haare J, Kooi ME, Vink H, Post MJ, van Teeffelen JW, Slenter J, Munts C, Cobelens H, Strijkers GJ, Koehn D, van Bilsen M. Early impairment of coronary microvascular perfusion capacity in rats on a high fat diet. Cardiovasc Diabetol. 2015;14:150

7.         Moritz MSM, Verbruggen SEL, Post MJ. Alternatives for large-scale production of cultured beef. Journal of Integrative Agriculture. 2015;14:3

8.         Hendrikx G, De Saint-Hubert M, Dijkgraaf I, Bauwens M, Douma K, Wierts R, Pooters I, Van den Akker NM, Hackeng TM, Post MJ, Mottaghy FM. Molecular imaging of angiogenesis after myocardial infarction by (111)in-dtpa-cngr and (99m)tc-sestamibi dual-isotope myocardial spect. EJNMMI Res. 2015;5:2

9.         Geenen IL, Molin DG, van den Akker NM, Jeukens F, Spronk HM, Schurink GW, Post MJ. Endothelial cells (ecs) for vascular tissue engineering: Venous ecs are less thrombogenic than arterial ecs. Journal of tissue engineering and regenerative medicine. 2015;9:564-576

10.       Caolo V, Vries MH, Zupancich J, Houben M, Mihov G, Wagenaar A, Swennen G, Nossent Y, Quax PH, Suylen D, Dijkgraaf I, Molin D, Hackeng TH, post MJ. Cxcl1 microspheres: A novel tool to stimulate arteriogenesis. Drug Delivery. 2015;EPub; ahead of print

11.       Caolo V, Swennen G, Chalaris A, Wagenaar A, Verbruggen S, Rose-John S, Molin DG, Vooijs M, Post MJ. Adam10 and adam17 have opposite roles during sprouting angiogenesis. Angiogenesis. 2015;18:13-22

12.       Wu G, Fanzo J, Miller DD, Pingali P, Post MJ, Steiner JL, Thalacker-Mercer AE. Production and supply of high-quality food protein for human consumption: Sustainability, challenges, and innovations. Ann N Y Acad Sci. 2014;1321:1-19

13.       Rahimi N, Swennen G, Verbruggen S, Scibiorek M, Molin DG, Post MJ. Short stimulation of electro-responsive paa/fibrin hydrogel induces collagen production. Tissue Eng Part C Methods. 2014;20:703-713

14.       Post MJ. An alternative animal protein source: Cultured beef. Ann N Y Acad Sci. 2014;1328:29-33

15.       Post MJ. Cultured beef: Medical technology to produce food. Journal of the science of food and agriculture. 2014;94:1039-1041

16.       Jetten N, Verbruggen S, Gijbels MJ, Post MJ, De Winther MP, Donners MM. Anti-inflammatory m2, but not pro-inflammatory m1 macrophages promote angiogenesis in vivo. Angiogenesis. 2014;17:109-118

17.       Jetten N, Roumans N, Gijbels MJ, Romano A, Post MJ, de Winther MP, van der Hulst RR, Xanthoulea S. Wound administration of m2-polarized macrophages does not improve murine cutaneous healing responses. PLoS One. 2014;9:e102994

18.       Geenen IL, Verbruggen S, Molin DG, Spronk HM, Maessen JG, Meesters B, Schurink GW, Post MJ. Phenotypic fitness of primary endothelial cells cultured from patients with high cardiovascular risk or chronic kidney disease for vascular tissue engineering. Tissue Eng Part A. 2014;20:1049-1059

19.       Wolters M, van Hoof RH, Wagenaar A, Douma K, van Zandvoort MA, Hackeng TH, Post MJ, Backes WH, Kooi ME. Mri artifacts in the ferric chloride thrombus animal model: An alternative solution: Preventing mri artifacts after thrombus induction with a non-ferromagnetic lewis acid. Journal of thrombosis and haemostasis : JTH. 2013;11:1766-1769

20.       Wolters M, Mohades SG, Hackeng TM, Post MJ, Kooi ME, Backes WH. Clinical perspectives of hybrid proton-fluorine magnetic resonance imaging and spectroscopy. Invest Radiol. 2013;48:341-350

21.       van den Akker NM, Post MJ. Career switch for ec-cfu to modelling. Cardiovasc Res. 2013;100:175-177

22.       Smulders MW, Kietselaer BL, Das M, Wildberger JE, Crijns HJ, Veenstra LF, Brunner-La Rocca HP, van Dieijen-Visser MP, Mingels AM, Dagnelie PC, Post MJ, Gorgels AP, van Asselt AD, Vogel G, Schalla S, Kim RJ, Bekkers SC. The role of cardiovascular magnetic resonance imaging and computed tomography angiography in suspected non-st-elevation myocardial infarction patients: Design and rationale of the cardiovascular magnetic resonance imaging and computed tomography angiography (carmenta) trial. American heart journal. 2013;166:968-975

23.       Rademakers T, Douma K, Hackeng TM, Post MJ, Sluimer JC, Daemen MJ, Biessen EA, Heeneman S, van Zandvoort MA. Plaque-associated vasa vasorum in aged apolipoprotein e-deficient mice exhibit proatherogenic functional features in vivo. Arterioscler Thromb Vasc Biol. 2013;33:249-256

24.       Post MJ, Rahimi N, Caolo V. Update on vascularization in tissue engineering. Regen Med. 2013;8:759-770

25.       Post MJ, Breewood HE, van Essen AL. Cultured beef: Current status and challenges. Food Science & Technology. 2013;27:4

26.       Post MJ. Cultured beef: Medical technology to produce food. Journal of the science of food and agriculture. 2013

27.       Jetten N, Donners MM, Wagenaar A, Cleutjens JP, van Rooijen N, de Winther MP, Post MJ. Local delivery of polarized macrophages improves reperfusion recovery in a mouse hind limb ischemia model. PLoS One. 2013;8:e68811

28.       Ghosh M, van den Akker NM, Wijnands KA, Poeze M, Weber C, McQuade LE, Pluth MD, Lippard SJ, Post MJ, Molin DG, van Zandvoort MA. Specific visualization of nitric oxide in the vasculature with two-photon microscopy using a copper based fluorescent probe. PLoS One. 2013;8:e75331

29.       Wolters M, Oostendorp M, Coolen BF, Post MJ, Janssen JM, Strijkers GJ, Kooi ME, Nicolay K, Backes WH. Efficacy of positive contrast imaging techniques for molecular mri of tumor angiogenesis. Contrast media & molecular imaging. 2012;7:130-139

30.       van den Akker NM, Kolk FF, Jeukens F, Verbruggen S, Gagliardi M, Dullens S, Heschel I, Post MJ, Molin DG, Waltenberger J. Vascular potency of sus scrofa bone marrow-derived mesenchymal stem cells: A progenitor source of medial but not endothelial cells. Tissue engineering. Part A. 2012;18:828-839

31.       Rahimi N, Molin DG, Cleij TJ, van Zandvoort MA, Post MJ. Electrosensitive polyacrylic acid/fibrin hydrogel facilitates cell seeding and alignment. Biomacromolecules. 2012;13:1448-1457

32.       Post MJ. Remember what i told you about therapeutic arteriogenesis, 11 years ago? Cardiovasc Res. 2012;96:152-153; discussion 154-156

33.       Post MJ. Cultured meat from stem cells: Challenges and prospects. Meat Sci. 2012;92:297-301

34.       Jaspers K, Slenter JM, Leiner T, Wagenaar A, Post MJ, Backes WH. Automated multiscale vessel analysis for the quantification of mr angiography of peripheral arteriogenesis. J Magn Reson Imaging. 2012;35:379-386

35.       Geenen IL, Post MJ, Molin DG, Schurink GW, Maessen JG, van Oerle R, ten Cate H, Spronk HM. Coagulation on endothelial cells: The underexposed part of virchow's triad. Thrombosis and haemostasis. 2012;108:863-871

36.       Caolo V, Molin DG, Post MJ. Notch regulation of hematopoiesis, endothelial precursor cells, and blood vessel formation: Orchestrating the vasculature. Stem Cells International. 2012;2012:805602

37.       van den Wijngaard JP, Schulten H, van Horssen P, Ter Wee RD, Siebes M, Post MJ, Spaan JA. Porcine coronary collateral formation in the absence of a pressure gradient remote of the ischemic border zone. Am J Physiol Heart Circ Physiol. 2011;300:H1930-1937

38.       Oostendorp M, de Vries EE, Slenter JM, Peutz-Kootstra CJ, Snoeijs MG, Post MJ, van Heurn LW, Backes WH. Mri of renal oxygenation and function after normothermic ischemia-reperfusion injury. NMR Biomed. 2011;24:194-200

39.       Langelaan ML, Boonen KJ, Rosaria-Chak KY, van der Schaft DW, Post MJ, Baaijens FP. Advanced maturation by electrical stimulation: Differences in response between c2c12 and primary muscle progenitor cells. Journal of tissue engineering and regenerative medicine. 2011;5:529-539

40.       Jaspers K, Versluis B, Leiner T, Dijkstra P, Oostendorp M, van Golde JM, Post MJ, Backes WH. Mr angiography of collateral arteries in a hind limb ischemia model: Comparison between blood pool agent gadomer and small contrast agent gd-dtpa. PLoS One. 2011;6:e16159

41.       Caolo V, Schulten HM, Zhuang ZW, Murakami M, Wagenaar A, Verbruggen S, Molin DG, Post MJ. Soluble jagged-1 inhibits neointima formation by attenuating notch-herp2 signaling. Arterioscler Thromb Vasc Biol. 2011;31:1059-1065

42.       Boonen KJ, van der Schaft DW, Baaijens FP, Post MJ. Interaction between electrical stimulation, protein coating and matrix elasticity: A complex effect on muscle fibre maturation. Journal of tissue engineering and regenerative medicine. 2011;5:60-68

43.       Oostendorp M, Douma K, Wagenaar A, Slenter JM, Hackeng TM, van Zandvoort MA, Post MJ, Backes WH. Molecular magnetic resonance imaging of myocardial angiogenesis after acute myocardial infarction. Circulation. 2010;121:775-783

44.       Oostendorp M, Douma K, Hackeng TM, van Zandvoort MA, Post MJ, Backes WH. Pharmacokinetics of contrast agents targeted to the tumor vasculature in molecular magnetic resonance imaging. Contrast media & molecular imaging. 2010;5:9-17

45.       Oostendorp M, Douma K, Hackeng TM, Post MJ, van Zandvoort MA, Backes WH. Gadolinium-labeled quantum dots for molecular magnetic resonance imaging: R1 versus r2 mapping. Magn Reson Med. 2010;64:291-298

46.       Molin DG, van den Akker NM, Post MJ. 'Lox on neovascularization': Leukotrienes as mediators in endothelial biology. Cardiovasc Res. 2010;86:6-8

47.       Langelaan ML, Boonen KJ, Polak RB, Baaijens FP, Post MJ, van der Schaft DW. Meet the new meat: Tissue engineered skeletal muscle. Trends Food Sci Technol. 2010;21:7

48.       Jaspers K, Leiner T, Dijkstra P, Oostendorp M, van Golde JM, Post MJ, Backes WH. Optimized pharmacokinetic modeling for the detection of perfusion differences in skeletal muscle with dce-mri: Effect of contrast agent size. Medical physics. 2010;37:5746-5755

49.       Douma K, Oostendorp M, Slaaf DW, Post MJ, Backes WH, van Zandvoort MA. Evaluation of magnetic resonance vessel size imaging by two-photon laser scanning microscopy. Magn Reson Med. 2010;63:930-939

50.       Donners MM, Wolfs IM, Olieslagers S, Mohammadi-Motahhari Z, Tchaikovski V, Heeneman S, van Buul JD, Caolo V, Molin DG, Post MJ, Waltenberger J. A disintegrin and metalloprotease 10 is a novel mediator of vascular endothelial growth factor-induced endothelial cell function in angiogenesis and is associated with atherosclerosis. Arterioscler Thromb Vasc Biol. 2010;30:2188-2195

51.       Caolo V, van den Akker NM, Verbruggen S, Donners MM, Swennen G, Schulten H, Waltenberger J, Post MJ, Molin DG. Feed-forward signaling by membrane bound ligand receptor circuit: The case of notch-delta like 4 in endothelial cells. The Journal of biological chemistry. 2010

52.       Boonen KJ, Langelaan ML, Polak RB, van der Schaft DW, Baaijens FP, Post MJ. Effects of a combined mechanical stimulation protocol: Value for skeletal muscle tissue engineering. Journal of biomechanics. 2010;43:1514-1521

53.       Pullens RA, Stekelenburg M, Baaijens FP, Post MJ. The influence of endothelial cells on the ecm composition of 3d engineered cardiovascular constructs. Journal of tissue engineering and regenerative medicine. 2009;3:11-18

54.       Oostendorp M, Post MJ, Backes WH. Vessel growth and function: Depiction with contrast-enhanced mr imaging. Radiology. 2009;251:317-335

55.       Lobbes MB, Miserus RJ, Heeneman S, Passos VL, Mutsaers PH, Debernardi N, Misselwitz B, Post M, Daemen MJ, van Engelshoven JM, Leiner T, Kooi ME. Atherosclerosis: Contrast-enhanced mr imaging of vessel wall in rabbit model--comparison of gadofosveset and gadopentetate dimeglumine. Radiology. 2009;250:682-691

56.       Jaspers K, Aerts HJ, Leiner T, Oostendorp M, van Riel NA, Post MJ, Backes WH. Reliability of pharmacokinetic parameters: Small vs. Medium-sized contrast agents. Magn Reson Med. 2009;62:779-787

57.       Douma K, Prinzen L, Slaaf DW, Reutelingsperger CP, Biessen EA, Hackeng TM, Post MJ, van Zandvoort MA. Nanoparticles for optical molecular imaging of atherosclerosis. Small (Weinheim an der Bergstrasse, Germany). 2009

58.       Boonen KJ, Rosaria-Chak KY, Baaijens FP, van der Schaft DW, Post MJ. Essential environmental cues from the satellite cell niche: Optimizing proliferation and differentiation. American journal of physiology. Cell physiology. 2009;296:C1338-1345

59.       van Golde JM, Ruiter MS, Schaper NC, Voo S, Waltenberger J, Backes WH, Post MJ, Huijberts MS. Impaired collateral recruitment and outward remodeling in experimental diabetes. Diabetes. 2008;57:2818-2823

60.       Oostendorp M, Douma K, Hackeng TM, Dirksen A, Post MJ, van Zandvoort MA, Backes WH. Quantitative molecular magnetic resonance imaging of tumor angiogenesis using cngr-labeled paramagnetic quantum dots. Cancer Res. 2008;68:7676-7683

61.       Molin DG, van den Akker NM, Post MJ. Affirmative action of osteopontin on endothelial progenitors. Arterioscler Thromb Vasc Biol. 2008;28:2099-2100

62.       Boonen KJ, Post MJ. The muscle stem cell niche: Regulation of satellite cells during regeneration. Tissue engineering. Part B, Reviews. 2008;14:419-431

63.       Molin D, Post MJ. Therapeutic angiogenesis in the heart: Protect and serve. Curr Opin Pharmacol. 2007;7:158-163

64.       de Lussanet QG, van Golde JC, Beets-Tan RG, Post MJ, Huijberts MS, Schaper NC, Kessels AG, van Engelshoven JM, Backes WH. Dynamic contrast-enhanced mri of muscle perfusion combined with mr angiography of collateral artery growth in a femoral artery ligation model. NMR Biomed. 2007

65.       Radke PW, Heinl-Green A, Frass OM, Post MJ, Sato K, Geddes DM, Alton EW. Evaluation of the porcine ameroid constrictor model of myocardial ischemia for therapeutic angiogenesis studies. Endothelium. 2006;13:25-33

66.       Post MJ, Waltenberger J. Ace inhibitors and statins for bone marrow failure following myocardial infarction? Cardiovasc Res. 2006;70:1-2

67.       Post MJ, Sato K, Murakami M, Bao J, Tirziu D, Pearlman JD, Simons M. Adenoviral pr39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation. Am J Physiol Regul Integr Comp Physiol. 2006;290:R494-500

68.       Molin DG, Post MJ. Do intrinsic arterial wall features determine atherosclerosis susceptibility? Cardiovasc Res. 2006;72:3-4

69.       de Lussanet QG, van Golde JC, Beets-Tan RG, de Haan MW, Zaar DV, Post MJ, Huijberts MS, Schaper NC, van Engelshoven JM, Backes WH. Magnetic resonance angiography of collateral vessel growth in a rabbit femoral artery ligation model. NMR Biomed. 2006;19:77-83

70.       Buehler A, van Zandvoort MA, Stelt BJ, Hackeng TM, Schrans-Stassen BH, Bennaghmouch A, Hofstra L, Cleutjens JP, Duijvestijn A, Smeets MB, de Kleijn DP, Post MJ, de Muinck ED. Cngr: A novel homing sequence for cd13/apn targeted molecular imaging of murine cardiac angiogenesis in vivo. Arterioscler Thromb Vasc Biol. 2006;26:2681-2687

71.       Schrans-Stassen BH, Lue H, Sonnemans DG, Bernhagen J, Post MJ. Stimulation of vascular smooth muscle cell migration by macrophage migration inhibitory factor. Antioxid Redox Signal. 2005;7:1211-1216

72.       Post M, Waltenberger J. Modulation of growth factor action in the cardiovascular system. Cardiovasc Res. 2005;65:547-549

73.       Laham RJ, Post M, Rezaee M, Donnell-Fink L, Wykrzykowska JJ, Lee SU, Baim DS, Sellke FW. Transendocardial and transepicardial intramyocardial fibroblast growth factor-2 administration: Myocardial and tissue distribution. Drug Metab Dispos. 2005;33:1101-1107

74.       Cao Y, Hong A, Schulten H, Post MJ. Update on therapeutic neovascularization. Cardiovasc Res. 2005;65:639-648

75.       Grinberg OY, Hou H, Grinberg SA, Moodie KL, Demidenko E, Friedman BJ, Post MJ, Swartz HM. Po2 and regional blood flow in a rabbit model of limb ischemia. Physiol Meas. 2004;25:659-670

76.       Degabriele NM, Griesenbach U, Sato K, Post MJ, Zhu J, Williams J, Jeffery PK, Geddes DM, Alton EW. Critical appraisal of the mouse model of myocardial infarction. Exp Physiol. 2004;89:497-505

77.       van Beusekom HM, Post MJ, Whelan DM, de Smet BJ, Duncker DJ, van der Giessen WJ. Metalloproteinase inhibition by batimastat does not reduce neointimal thickening in stented atherosclerotic porcine femoral arteries. Cardiovasc Radiat Med. 2003;4:186-191

78.       Storey P, Danias PG, Post M, Li W, Seoane PR, Harnish PP, Edelman RR, Prasad PV. Preliminary evaluation of evp 1001-1: A new cardiac-specific magnetic resonance contrast agent with kinetics suitable for steady-state imaging of the ischemic heart. Invest Radiol. 2003;38:642-652

79.       Soucy NV, Ihnat MA, Kamat CD, Hess L, Post MJ, Klei LR, Clark C, Barchowsky A. Arsenic stimulates angiogenesis and tumorigenesis in vivo. Toxicol Sci. 2003;76:271-279

80.       Post MJ, Simons M. The rational phase of therapeutic angiogenesis. Minerva Cardioangiol. 2003;51:421-432

81.       Mandinov L, Mandinova A, Kyurkchiev S, Kyurkchiev D, Kehayov I, Kolev V, Soldi R, Bagala C, de Muinck ED, Lindner V, Post MJ, Simons M, Bellum S, Prudovsky I, Maciag T. Copper chelation represses the vascular response to injury. Proc Natl Acad Sci U S A. 2003;100:6700-6705

82.       Laham RJ, Rezaee M, Post M, Xu X, Sellke FW. Intrapericardial administration of basic fibroblast growth factor: Myocardial and tissue distribution and comparison with intracoronary and intravenous administration. Catheter Cardiovasc Interv. 2003;58:375-381

83.       Laham RJ, Li J, Tofukuji M, Post M, Simons M, Sellke FW. Spatial heterogeneity in vegf-induced vasodilation: Vegf dilates microvessels but not epicardial and systemic arteries and veins. Ann Vasc Surg. 2003;17:245-252

84.       Hughes GC, Post MJ, Simons M, Annex BH. Translational physiology: Porcine models of human coronary artery disease: Implications for preclinical trials of therapeutic angiogenesis. J Appl Physiol. 2003;94:1689-1701

85.       HajMohammadi S, Enjyoji K, Princivalle M, Christi P, Lech M, Beeler D, Rayburn H, Schwartz JJ, Barzegar S, de Agostini AI, Post MJ, Rosenberg RD, Shworak NW. Normal levels of anticoagulant heparan sulfate are not essential for normal hemostasis. J Clin Invest. 2003;111:989-999

86.       Gaczynska M, Osmulski PA, Gao Y, Post MJ, Simons M. Proline- and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity. Biochemistry. 2003;42:8663-8670

87.       Cao R, Brakenhielm E, Pawliuk R, Wariaro D, Post MJ, Wahlberg E, Leboulch P, Cao Y. Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of pdgf-bb and fgf-2. Nat Med. 2003;9:604-613

88.       Braun A, Zhang S, Miettinen HE, Ebrahim S, Holm TM, Vasile E, Post MJ, Yoerger DM, Picard MH, Krieger JL, Andrews NC, Simons M, Krieger M. Probucol prevents early coronary heart disease and death in the high-density lipoprotein receptor sr-bi/apolipoprotein e double knockout mouse. Proc Natl Acad Sci U S A. 2003;100:7283-7288

89.       Skalak TC, Little CD, McIntire LV, Hirschi KK, Tranquillo RT, Post M, Ranieri J. Vascular assembly in engineered and natural tissues: Breakout session summary. Ann N Y Acad Sci. 2002;961:255-257

90.       Ruel M, Laham RJ, Parker JA, Post MJ, Ware JA, Simons M, Sellke FW. Long-term effects of surgical angiogenic therapy with fibroblast growth factor 2 protein. J Thorac Cardiovasc Surg. 2002;124:28-34

91.       Post MJ, Laham RJ, Kuntz RE, Novicki D, Simons M. The effect of intracoronary fibroblast growth factor-2 on restenosis after primary angioplasty or stent placement in a pig model of atherosclerosis. Clin Cardiol. 2002;25:271-278

92.       Post MJ. Angiogenesis: Initiation and maintenance. Ann N Y Acad Sci. 2002;961:249-250.

93.       Post M, Simons M. Adenoviral gene therapy with pr39 peptide in chronically ischemic myocardium. ENDOTHELIUM-YVERDON-. 2002;9

94.       Pearlman JD, Laham RJ, Post M, Leiner T, Simons M. Medical imaging techniques in the evaluation of strategies for therapeutic angiogenesis. Curr Pharm Des. 2002;8:1467-1496

95.       Braun A, Trigatti BL, Post MJ, Sato K, Simons M, Edelberg JM, Rosenberg RD, Schrenzel M, Krieger M. Loss of sr-bi expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein e-deficient mice. Circulation Research. 2002;90:270-276

96.       Wentzel JJ, Kloet J, Andhyiswara I, Oomen JA, Schuurbiers JC, de Smet BJ, Post MJ, de Kleijn D, Pasterkamp G, Borst C, Slager CJ, Krams R. Shear-stress and wall-stress regulation of vascular remodeling after balloon angioplasty: Effect of matrix metalloproteinase inhibition. Circulation. 2001;104:91-96.

97.       Weiler H, Lindner V, Kerlin B, Isermann BH, Hendrickson SB, Cooley BC, Meh DA, Mosesson MW, Shworak NW, Post MJ, Conway EM, Ulfman LH, von Andrian UH, Weitz JI. Characterization of a mouse model for thrombomodulin deficiency. Arterioscler Thromb Vasc Biol. 2001;21:1531-1537.

98.       Simons M, Post MJ. Coronary artery disease: Vascular endothelial growth factor and fibroblast growth factor. Curr Interv Cardiol Rep. 2001;3:185-191.

99.       Sato K, Wu T, Laham RJ, Johnson RB, Douglas P, Li J, Sellke FW, Bunting S, Simons M, Post MJ. Efficacy of intracoronary or intravenous vegf165 in a pig model of chronic myocardial ischemia. Journal of the American College of Cardiology. 2001;37:616-623

100.     Post MJ, Simons M. Gene therapy versus protein-based therapy: A matter of pharmacokinetics. Drug Discov Today. 2001;6:769-770.

101.     Post MJ, Laham R, Sellke FW, Simons M. Therapeutic angiogenesis in cardiology with protein formulations. Cardiovascular Research. 2001;49:522-531

102.     Pearlman JD, Gertz ZM, Wu Y, Simons M, Post MJ. Serial motion assessment by reference tracking (smart): Application to detection of local functional impact of chronic myocardial ischemia. J Comput Assist Tomogr. 2001;25:558-562.

103.     Laham RJMAPMJSF. Gene transfer to induce angiogenesis in myocardial and limb ischaemia. Expert Opinion on Biological Therapy. 2001;1:985-994

104.     Bao J, Sato K, Li M, Gao Y, Abid R, Aird W, Simons M, Post MJ. Pr-39 and pr-11 peptides inhibit ischemia-reperfusion injury by blocking proteasome-mediated ikappabalpha degradation. Am J Physiol Heart Circ Physiol. 2001;281:H2612-2618.

105.     Bao J, Naimark W, Palasis M, Laham R, Simons M, Post MJ. Intramyocardial delivery of fgf2 in combination with radio frequency transmyocardial revascularization. Catheter Cardiovasc Interv. 2001;53:429-434.

106.     Simons M, Laham RJ, Post M, Sellke FW. Therapeutic angiogenesis: Potential role of basic fibroblast growth factor in patients with severe ischaemic heart disease. BioDrugs. 2000;14:13-20

107.     Sato K, Laham RJ, Pearlman JD, Novicki D, Sellke FW, Simons M, Post MJ. Efficacy of intracoronary versus intravenous fgf-2 in a pig model of chronic myocardial ischemia.[in process citation]. Ann Thorac Surg. 2000;70:2113-2118

108.     Post MJ, Sato K, Kornowski R, Epstein SE, Leon MB, Baim D, Simons M, Laham RJ. Adenovirus mediated gene therapy through intramyocardial injections: Percutaneous intramyocardial versus surgical epicardial delivery. Cardiac and Vascular Regeneration. 2000;1:106-113

109.     Li J, Post M, Volk R, Gao Y, Li M, Metais C, Sato K, Tsai J, Aird W, Rosenberg RD, Hampton TG, Sellke F, Carmeliet P, Simons M. Pr39, a peptide regulator of angiogenesis. Nat Med. 2000;6:49-55

110.     Laham RJ, Rezaee M, Post M, Novicki D, Sellke FW, Pearlman JD, Simons M, Hung D. Intrapericardial delivery of fibroblast growth factor-2 induces neovascularization in a porcine model of chronic myocardial ischemia. J Pharmacol Exp Ther. 2000;292:795-802

111.     Gao Y, Lecker S, Post MJ, Hietaranta AJ, Li J, Volk R, Li M, Sato K, Saluja AK, Steer ML, Goldberg AL, Simons M. Inhibition of ubiquitin-proteasome pathway-mediated i kappa b alpha degradation by a naturally occurring antibacterial peptide. J Clin Invest. 2000;106:439-448

112.     de Smet BJ, de Kleijn D, Hanemaaijer R, Verheijen JH, Robertus L, van Der Helm YJ, Borst C, Post MJ. Metalloproteinase inhibition reduces constrictive arterial remodeling after balloon angioplasty: A study in the atherosclerotic yucatan micropig. Circulation. 2000;101:2962-2967

113.     Colorado PC, Torre A, Kamphaus G, Maeshima Y, Hopfer H, Takahashi K, Volk R, Zamborsky ED, Herman S, Sarkar PK, Ericksen MB, Dhanabal M, Simons M, Post M, Kufe DW, Weichselbaum RR, Sukhatme VP, Kalluri R. Anti-angiogenic cues from vascular basement membrane collagen [in process citation]. Cancer Res. 2000;60:2520-2526

114.     Verheye S, Salame MY, Robinson KA, Post MJ, Carrozza JP, Jr., Baim DS, Sigwart U, King SB, 3rd, Chronos NA. Short- and long-term histopathologic evaluation of stenting using a self-expanding nitinol stent in pig carotid and iliac arteries [in process citation]. Catheter Cardiovasc Interv. 1999;48:316-323

115.     Laham RJ, Rezaee M, Post M, Sellke FW, Braeckman RA, Hung D, Simons M. Intracoronary and intravenous administration of basic fibroblast growth factor: Myocardial and tissue distribution. Drug Metab Dispos. 1999;27:821-826

116.     Laham RJ, Garcia L, Baim DS, Post M, Simons M. Therapeutic angiogenesis using basic fibroblast growth factor and vascular endothelial growth factor using various delivery strategies. Curr Interv Cardiol Rep. 1999;1:228-233

117.     Garcia L, Baim DS, Post M, Simons M, Laham RJ. Therapeutic angiogenesis using endocardial approach to administration: Techniques and results. Current interventional cardiology reports. 1999;1:222

118.     van Leeuwen TG, Velema E, Pasterkamp G, Post MJ, Borst C. Saline flush during excimer laser angioplasty: Short and long term effects in the rabbit femoral artery. Lasers Surg Med. 1998;23:128-140

119.     Krams R, Wentzel JJ, Oomen JA, Schuurbiers JC, Andhyiswara I, Kloet J, Post M, de Smet B, Borst C, Slager CJ, Serruys PW. Shear stress in atherosclerosis, and vascular remodelling. Semin Interv Cardiol. 1998;3:39-44

120.     de Smet BJ, van der Zande J, van der Helm YJ, Kuntz RE, Borst C, Post MJ. The atherosclerotic yucatan animal model to study the arterial response after balloon angioplasty: The natural history of remodeling. Cardiovasc Res. 1998;39:224-232

121.     de Smet BJ, Pasterkamp G, van der Helm YJ, Borst C, Post MJ. The relation between de novo atherosclerosis remodeling and angioplasty- induced remodeling in an atherosclerotic yucatan micropig model. Arterioscler Thromb Vasc Biol. 1998;18:702-707

122.     Post MJ, de Smet BJ, van der Helm Y, Borst C, Kuntz RE. Arterial remodeling after balloon angioplasty or stenting in an atherosclerotic experimental model. Circulation. 1997;96:996-1003

123.     Pasterkamp G, Wensing PJ, Hillen B, Post MJ, Mali WP, Borst C. Impact of local atherosclerotic remodeling on the calculation of percent luminal narrowing. Am J Cardiol. 1997;79:402-405

124.     Kuntz RE, Post M. Coronary remodeling and interventional strategies. Arterial Remodeling: A Critical Factor in Restenosis. 1997:471-504

125.     Doornekamp FN, Borst C, Post MJ. The influence of lesion length on intimal hyperplasia after fogarty balloon injury in the rabbit carotid artery: Role of endothelium. J Vasc Res. 1997;34:260-266

126.     de Smet BJ, Kuntz RE, van der Helm YJ, Pasterkamp G, Borst C, Post MJ. Relationship between plaque mass and neointimal hyperplasia after stent placement in yucatan micropigs. Radiology. 1997;203:484-488

127.     Dam JP, Vleeming W, Riezebos J, Post MJ, Porsius AJ, Wemer J. Effects of hypercholesterolemia on the contractions to angiotensin ii in the isolated aorta and iliac artery of the rabbit: Role of arachidonic acid metabolites. J Cardiovasc Pharmacol. 1997;30:118-123

128.     Post MJ, Pasterkamp G, Mali WP, Borst C. Computation of a location shift between two subsequent intra vascular ultrasound registrations by cross-correlation analysis of the lumen area functions. Ultrasound Med Biol. 1996;22:239-243

129.     Post MJ, de Graaf-Bos AN, van Zanten HG, de Groot PG, Sixma JJ, Borst C. Thrombogenicity of the human arterial wall after interventional thermal injury. J Vasc Res. 1996;33:156-163

130.     Post MJ, de Graaf-Bos AN, Posthuma G, de Groot PG, Sixma JJ, Borst C. Interventional thermal injury of the arterial wall: Unfolding of von willebrand factor and its increased binding to collagen after 55 degrees c heating. Thrombosis and haemostasis. 1996;75:515-519

131.     Pasterkamp G, Borst C, Post MJ, Mali WP, Wensing PJ, Gussenhoven EJ, Hillen B. Atherosclerotic arterial remodeling in the superficial femoral artery. Individual variation in local compensatory enlargement response [see comments]. Circulation. 1996;93:1818-1825

132.     Doornekamp FN, Borst C, Post MJ. Endothelial cell recoverage and intimal hyperplasia after endothelium removal with or without smooth muscle cell necrosis in the rabbit carotid artery. J Vasc Res. 1996;33:146-155

133.     Doornekamp FN, Borst C, Haudenschild CC, Post MJ. Fogarty and percutaneous transluminal coronary angioplasty balloon injury induce comparable damage to the arterial wall but lead to different healing responses. J Vasc Surg. 1996;24:843-850

134.     Post MJ, Kuntz RE, Borst C. Remodeling after ptca: From shrinkage to compensatory enlargement [letter; comment]. Circulation. 1995;92:2002-2003

135.     Post MJ, Borst C, Pasterkamp G, Haudenschild CC. Arterial remodeling in atherosclerosis and restenosis: A vague concept of a distinct phenomenon. Atherosclerosis. 1995;118 Suppl:S115-123

136.     Pasterkamp G, Wensing PJ, Post MJ, Hillen B, Mali WP, Borst C. Paradoxical arterial wall shrinkage may contribute to luminal narrowing of human atherosclerotic femoral arteries. Circulation. 1995;91:1444-1449

137.     Pasterkamp G, van der Heiden MS, Post MJ, Borst C, Gussenhoven EJ, Pieterman H, van Urk H, Bom N. Discrimination of intravascular lumen and dissections in single intravascular ultrasound images using subtraction, conventional averaging and saline flush. Ultrasound Med Biol. 1995;21:149-156

138.     Pasterkamp G, Borst C, Gussenhoven EJ, Mali WP, Post MJ, The SH, Reekers JA, van den Berg FG. Remodeling of de novo atherosclerotic lesions in femoral arteries: Impact on mechanism of balloon angioplasty. J Am Coll Cardiol. 1995;26:422-428

139.     van Erven L, Post MJ, Velema E, Borst C. In the normal rabbit femoral artery increasing arterial wall injury does not lead to increased intimal hyperplasia. J Vasc Res. 1994;31:153-162

140.     Post MJ, Borst C, Kuntz RE. The relative importance of arterial remodeling compared with intimal hyperplasia in lumen renarrowing after balloon angioplasty. A study in the normal rabbit and the hypercholesterolemic yucatan micropig [see comments]. Circulation. 1994;89:2816-2821

141.     van Leeuwen TG, Meertens JH, Velema E, Post MJ, Borst C. Intraluminal vapor bubble induced by excimer laser pulse causes microsecond arterial dilation and invagination leading to extensive wall damage in the rabbit [see comments]. Circulation. 1993;87:1258-1263

142.     Pasterkamp G, van der Heiden MS, Post MJ, Ter Haar Romeny BM, Mali WP, Borst C. Discrimination of the intravascular lumen and dissections in a single 30-mhz us image: Use of "confounding" blood backscatter to advantage. Radiology. 1993;187:871-872

143.     Bos AN, Post MJ, de Groot PG, Sixma JJ, Borst C. Both increased and decreased platelet adhesion to thermally injured subendothelium is caused by denaturation of von willebrand factor. Circulation. 1993;88:1196-1204

144.     Borst C, van Leeuwen TG, Post MJ. In search of the optimized excimer laser angioplasty system [letter; comment]. Circulation. 1993;88:334-335

145.     van Leeuwen TG, van Erven L, Meertens JH, Motamedi M, Post MJ, Borst C. Origin of arterial wall dissections induced by pulsed excimer and mid- infrared laser ablation in the pig [see comments]. J Am Coll Cardiol. 1992;19:1610-1618

146.     van Erven L, Velema E, Bos AN, Post MJ, Borst C. Thrombogenicity and intimal hyperplasia after conventional and thermal balloon dilation in normal rabbit iliac arteries. J Vasc Res. 1992;29:426-434

147.     van Erven L, van Leeuwen TG, Post MJ, van der Veen MJ, Velema E, Borst C. Mid-infrared pulsed laser ablation of the arterial wall. Mechanical origin of "acoustic" wall damage and its effect on wall healing. J Thorac Cardiovasc Surg. 1992;104:1053-1059

148.     Smits PC, Post MJ, Velema E, Rienks R, Borst C. Percutaneous coronary and peripheral angioscopy with saline solution and carbon dioxide gas in porcine and canine arteries. American heart journal. 1991;122:1315-1322

149.     Post MJ, te Biesebeek JD, Wemer J, van Rooij HH, Porsius AJ. Effects of milrinone, sulmazole and theophylline on adenosine enhancement of antigen-induced bronchoconstriction and mediator release in rat isolated lungs. Pulm Pharmacol. 1991;4:239-246

150.     Post MJ, Te Biesebeek JD, Doods HN, Wemer J, Van Rooji HH, Porsius AJ. Functional characterization of the muscarinic receptor in rat lungs. Eur J Pharmacol. 1991;202:67-72

151.     Borst C, Savalle LH, Smits PC, Post MJ, Gussenhoven WJ, Bom N. Imaging of post-mortem coronary arteries by 30 mhz intravascular ultrasound. Int J Card Imaging. 1991;6:239-246

152.     Post MJ, te Biesebeek JD, Wemer J, van Rooij HH, Porsius AJ. Adenosine enhances antigen-induced bronchoconstriction and histamine release in rat isolated lungs. Agents Actions. 1990;30:30-33

153.     Post MJ, Moekoet C, Wemer J, van Rooij HH, Porsius AJ. Modulation of histamine release by rat peritoneal mast cells in a superfusion set-up. Agents Actions. 1990;30:34-37

154.     Post MJ, te Biesebeek JD, Wemer J, van Rooij HH, Zijlstra FJ, Vermeer MA, Porsius AJ. Effects of milrinone and salbutamol on antigen induced arachidonic acid metabolism in the isolated rat lung. Biochem Pharmacol. 1989;38:2573-2574

155.     Post MJ, te Biesebeek JD, Wemer J, van Rooij HH, Porsius AJ. In vivo anaphylaxis in the rat: Effects of phosphodiesterase inhibitors. Agents Actions. 1989;26:79-81

156.     Post MJ, te Biesebeek JD, Wemer J, van Rooij HH, Porsius AJ. Comparison of the anti-anaphylactic effects of milrinone, sulmazole and theophylline in the rat. Int Arch Allergy Appl Immunol. 1989;89:6-10

157.     Post MJ, te Biesebeek JD, van Rooij HH, Wemer J, Porsius AJ. Anti-allergic effects of milrinone and sulmazole in isolated rat lungs in comparison with theophylline. Int Arch Allergy Appl Immunol. 1989;89:1-5

158.     Post MJ, van der Weele C. Principles of tissue engineering for food. In: Lanza R, Langer R, Vacanti JP, eds. Principles of tissue engineering. Amsterdam: Elsevier; 2014:1647-1658.

159.     Post M, Cornelussen R, Prinzen F. Pampering and priming the heart. In: Deindle E, Kupatt C, eds. Therapeutic neovascularization–quo vadis? Dordrecht: Springer; 2007:85-108.

160.     Simons M, Post MJ. Angiogenesis. In: Topol EJ, ed. Textbook of interventional cardiology. Philadelphia: Saunders; 2003:757-779.

161.     Simons M, Post MJ, Laham RJ, Sellke FW. Basic fibroblast growth factor trials for patients with advanced coronary disease. In: Braunwald E, ed. Harrison's advances in cardiology. New York: McGraw-Hill; 2002:248-254.

162.     Post M, Ware JA. Angiogenesis in atheroclerosis and restenosis. In: Ware JA, Simons M, eds. Angiogenesis and cardiovascular disease. New York: Oxford University Press; 1999:143-158.