Dr Ir Michiel Adriaens, Ph.D. (M.E.)
I am an Assistant Professor at the Maastricht Centre for Systems Biology. I have a background in genome-wide studies of genetic and epigenetic regulation of gene transcription and splicing, specifically in the context of cardiomyopathies and heart failure. In my current work, I focus on combining data-driven and mechanistic modeling approaches to predict and better understand the development of metabolic impairments in the failing heart. This causes the heart to become exhausted, leading to life-threatening complications. My goal is to develop the systems biology tools to detect these metabolic problems early and give directions to a patient-specific recovery.
After receiving my Master’s degree in Biomodeling & Bioinformatics from Eindhoven University of Technology (TU/e, department of Biomedical Engineering) in 2008, I started my academic career at the Department of Bioinformatics (BiGCaT) as a PhD student under guidance of Prof. Chris Evelo, supported by a Koostra Talent Fellowship. Focusing on developing tools for integrative analysis of DNA-methylation, ChIP-seq and transcriptomics data, I collaborated with the labs of Dr. Willem Voncken (GROW) and Prof. Brad Wouters (MAASTRO; Ontario Institute for Cancer Research, Canada) in the context of tumor biology, and with the lab of Prof. John Mathers (University of Newcastle) on studying the impact of maternal folate depletion on epigenetic marking and transcriptional regulation in offspring. I received my PhD in 2012 and moved to Amsterdam to work as a postdoc researcher in the lab of Prof. Connie Bezzina, at the Department of Experimental Cardiology of the AMC. As a biostatistician, I worked on multiple systems genetics studies on cardiac arrhythmia and heart failure, studying the genetic regulation of gene transcription and splicing in the diseased and non-diseased heart. In June 2015 I continued my research at the Maastricht Centre for Systems Biology (MaCSBio), where I became a tenured assistant professor in September 2016.