L.C. Hewitt

Tay, R. Y. K., Sachdeva, M., Ma, H., Kim, Y.-W., Kook, M.-C., Kim, H., Cheong, J.-H., Hewitt, L. C., Schmidt, G., Yoshikawa, T., Oshima, T., Arai, T., Srivastava, S., Teh, M., Ong, X., Tay, S. T., Sheng, T., Zhao, J. J., Tan, P., ... Sundar, R. (2025). Spatial organization of B lymphocytes and prognosis prediction in patients with gastric cancer. Gastric Cancer, 28(3), 384-396. Article e11769. https://doi.org/10.1007/s10120-025-01593-y

Liu, D. H. W., Kim, Y.-W., Sefcovicova, N., Laye, J. P., Hewitt, L. C., Irvine, A. F., Vromen, V., Janssen, Y., Davarzani, N., Fazzi, G. E., Jolani, S., Melotte, V., Magee, D. R., Kook, M.-C., Kim, H., Langer, R., Cheong, J.-H., & Grabsch, H. I. (2023). Tumour infiltrating lymphocytes and survival after adjuvant chemotherapy in patients with gastric cancer: post-hoc analysis of the CLASSIC trial. British Journal of Cancer, 128(12), 2318-2325. https://doi.org/10.1038/s41416-023-02257-3

Silva, A. N. S., Saito, Y., Yoshikawa, T., Oshima, T., Hayden, J. D., Oosting, J., Earle, S., Hewitt, L. C., Slaney, H. L., Wright, A., Inam, I., Langley, R. E., Allum, W. H., Nankivell, M. G., Hutchins, G., Cunningham, D., & Grabsch, H. I. (2022). Author response to: Increasing frequency of gene copy number aberrations is associated with immunosuppression and predicts poor prognosis in gastric adenocarcinoma. British Journal of Surgery, 109(9), E106. https://doi.org/10.1093/bjs/znac160

Silva, A. N. S., Saito, Y., Yoshikawa, T., Oshima, T., Hayden, J. D., Oosting, J., Earle, S., Hewitt, L. C., Slaney, H. L., Wright, A., Inam, I., Langley, R. E., Allum, W., Nankivell, M. G., Hutchins, G., Cunningham, D., & Grabsch, H. I. (2022). Increasing frequency of gene copy number aberrations is associated with immunosuppression and predicts poor prognosis in gastric adenocarcinoma. British Journal of Surgery, 109(3), 291-297. https://doi.org/10.1093/bjs/znab460

Sundar, R., Liu, D. H. W., Hutchins, G. G. A., Slaney, H. L., Silva, A. N. S., Oosting, J., Hayden, J. D., Hewitt, L. C., Ng, C. C. Y., Mangalvedhekar, A., Ng, S. B., Tan, I. B. H., Tan, P., & Grabsch, H. I. (2021). Spatial profiling of gastric cancer patient-matched primary and locoregional metastases reveals principles of tumour dissemination. Gut, 70(10), 1823-1832. https://doi.org/10.1136/gutjnl-2020-320805

Challoner, B. R., von Loga, K., Woolston, A., Griffiths, B., Sivamanoharan, N., Semiannikova, M., Newey, A., Barber, L. J., Mansfield, D., Hewitt, L. C., Saito, Y., Davarzani, N., Starling, N., Melcher, A., Grabsch, H. I., & Gerlinger, M. (2021). Computational Image Analysis of T-Cell Infiltrates in Resectable Gastric Cancer: Association with Survival and Molecular Subtypes. Journal of the National Cancer Institute, 113(1), 88-98. https://doi.org/10.1093/jnci/djaa051

Meier, A., Nekolla, K., Hewitt, L. C., Earle, S., Yoshikawa, T., Oshima, T., Miyagi, Y., Huss, R., Schmidt, G., & Grabsch, H. (2020). Hypothesis-free deep survival learning applied to the tumour microenvironment in gastric cancer. Journal of Pathology, 6(4), 273-282. https://doi.org/10.1002/cjp2.170

Kerckhoffs, K. G. P., Liu, D. H. W., Saragoni, L., van der Post, R. S., Langer, R., Bencivenga, M., Iglesias, M., Gallo, G., Hewitt, L. C., Fazzi, G. E., Vos, A. M., Renaud, F., Yoshikawa, T., Oshima, T., Tomezzoli, A., de Manzoni, G., Arai, T., Kushima, R., Carneiro, F., & Grabsch, H. (2020). Mucin expression in gastric- and gastro-oesophageal signet-ring cell cancer: results from a comprehensive literature review and a large cohort study of Caucasian and Asian gastric cancer. Gastric Cancer, 23(5), 765-779. https://doi.org/10.1007/s10120-020-01086-0

Davarzani, N., Hewitt, L. C., Hale, M. D., Melotte, V., Nankivell, M., Hutchins, G. G. A., Cunningham, D., Allum, W. H., Langley, R. E., Jolani, S., & Grabsch, H. I. (2020). Histological intratumoral heterogeneity in pretreatment esophageal cancer biopsies predicts survival benefit from neoadjuvant chemotherapy: results from the UK MRC OE02 trial. Diseases of the Esophagus, 33(8), Article doaa058. https://doi.org/10.1093/dote/doaa058

Sundar, R., Ng, A., Zouridis, H., Padmanabhan, N., Sheng, T., Zhang, S., Lee, M. H., Ooi, W. F., Qamra, A., Inam, I., Hewitt, L. C., So, J. B.-Y., Koh, V., Nankivell, M. G., Langley, R. E., Allum, W. H., Cunningham, D., Rozen, S. G., Yong, W. P., ... Tan, P. (2019). DNA epigenetic signature predictive of benefit from neoadjuvant chemotherapy in oesophageal adenocarcinoma: results from the MRC OE02 trial. European Journal of Cancer, 123, 48-57. https://doi.org/10.1016/j.ejca.2019.09.016