K.G.M. Savelkouls

Barbeau, L. M. O., Beelen, N. A., Savelkouls, K. G., Keulers, T. G. H., Wieten, L., & Rouschop, K. M. A. (2025). MAP1LC3C repression reduces CIITA- and HLA class II expression in non-small cell lung cancer. PLOS ONE, 20(2), Article e0316716. https://doi.org/10.1371/journal.pone.0316716

Sanchez-Castillo, A., Savelkouls, K. G., Baldini, A., Hounjet, J., Sonveaux, P., Verstraete, P., De Keersmaecker, K., Dewaele, B., Bjorkblom, B., Melin, B., Wu, W. Y., Sjoberg, R. L., Rouschop, K. M. A., Broen, M. P. G., Vooijs, M., & Kampen, K. R. (2024). Sertraline/chloroquine combination therapy to target hypoxic and immunosuppressive serine/glycine synthesis-dependent glioblastomas. Oncogenesis, 13(1), Article 39. https://doi.org/10.1038/s41389-024-00540-3

Beaumont, J. E. J., Barbeau, L. M. O., Ju, J., Savelkouls, K. G., Bouwman, F. G., Zonneveld, M. I., Bronckaers, A., Kampen, K. R., Keulers, T. G. H., & Rouschop, K. M. A. (2024). Cancer EV stimulate endothelial glycolysis to fuel protein synthesis via mTOR and AMPKa activation. Journal of Extracellular Vesicles, 13(7), Article e12449. https://doi.org/10.1002/jev2.12449

Sánchez-Castillo, A., Heylen, E., Hounjet, J., Savelkouls, K. G., Lieuwes, N. G., Biemans, R., Dubois, L. J., Reynders, K., Rouschop, K. M., Vaes, R. D. W., De Keersmaecker, K., Lambrecht, M., Hendriks, L. E. L., De Ruysscher, D. K. M., Vooijs, M., & Kampen, K. R. (2024). Correction: Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer. British Journal of Cancer, 130(4), Article 701. https://doi.org/10.1038/s41416-024-02603-z

Sanchez-Castillo, A., Heylen, E., Hounjet, J., Savelkouls, K. G., Lieuwes, N. G., Biemans, R., Dubois, L. J., Reynders, K., Rouschop, K. M., Vaes, R. D. W., De Keersmaecker, K., Lambrecht, M., Hendriks, L. E. L., De Ruysscher, D. K. M., Vooijs, M., & Kampen, K. R. (2024). Targeting serine/glycine metabolism improves radiotherapy response in non-small cell lung cancer. British Journal of Cancer, 130(4), 568-584. https://doi.org/10.1038/s41416-023-02553-y

Beaumont, J. E. J., Ju, J., Barbeau, L. M. O., Demers, I., Savelkouls, K. G., Derks, K., Bouwman, F. G., Wauben, M. H. M., Zonneveld, M. I., Keulers, T. G. H., & Rouschop, K. M. A. (2024). GABARAPL1 is essential in extracellular vesicle cargo loading and metastasis development. Radiotherapy and Oncology, 190, Article 109968. https://doi.org/10.1016/j.radonc.2023.109968

Keulers, T. G., Koch, A., van Gisbergen, M. W., Barbeau, L. M. O., Zonneveld, M. I., de Jong, M. C., Savelkouls, K. G. M., Wanders, R. G., Bussink, J., Melotte, V., & Rouschop, K. M. A. (2022). ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer. Autophagy, 18(8), 1898-1914. https://doi.org/10.1080/15548627.2021.2008690

Keulers, T. G., Libregts, S. F., Beaumont, J. E. J., Savelkouls, K. G., Bussink, J., Duimel, H., Dubois, L., Zonneveld, M. I., Lopez-Iglesias, C., Bezstarosti, K., Demmers, J. A., Vooijs, M., Wauben, M., & Rouschop, K. M. A. (2021). Secretion of pro-angiogenic extracellular vesicles during hypoxia is dependent on the autophagy-related protein GABARAPL1. Journal of Extracellular Vesicles, 10(14), Article e12166. https://doi.org/10.1002/jev2.12166

Jutten, B., Keulers, T. G., Peeters, H. J. M., Schaaf, M. B. E., Savelkouls, K. G. M., Compter, I., Clarijs, R., Schijns, O. E. M. G., Ackermans, L., Teernstra, O. P. M., Zonneveld, M. I., Colaris, R. M. E., Dubois, L., Vooijs, M. A., Bussink, J., Sotelo, J., Theys, J., Lammering, G., & Rouschop, K. M. A. (2018). EGFRvIII expression triggers a metabolic dependency and therapeutic vulnerability sensitive to autophagy inhibition. Autophagy, 14(2), 283-295. https://doi.org/10.1080/15548627.2017.1409926

Keulers, T. G., Schaaf, M. B. E., Peeters, H. J. M., Savelkouls, K. G. M., Vooijs, M. A., Bussink, J., Jutten, B., & Rouschop, K. M. A. (2015). GABARAPL1 is required for increased EGFR membrane expression during hypoxia. Radiotherapy and Oncology, 116(3), 417-422. https://doi.org/10.1016/j.radonc.2015.06.023