Dr G.A.F. Nicolaes

van Mourik, N., van Amstel, R. B. E., Slim, M. A., van Vught, L. A., van der Poll, T., Huckriede, J., de Vries, F., de Kimpe, S. J., Crabbe, R., van Leeuwen, S. J. M., Ekhart, P. F., Reutelingsperger, C. P. M., Nicolaes, G. A. F., Vlaar, A. P. J., & Mueller, M. C. A. (2025). A phase I trial evaluating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenously administered low-anticoagulant heparin (M6229) in critically ill sepsis patients. Intensive Care Medicine Experimental, 13(1), Article 84. https://doi.org/10.1186/s40635-025-00790-4

Postmus, T., Jansen, R., Kaijen, P., van Alphen, F. P. J., van der Zwaan, C., Hoogendijk, A. J., Coppo, P., Joly, B. S., Veyradier, A., Vanhoorelbeke, K., Nicolaes, G. A. F., & Voorberg, J. (2025). Trp1250, Lys1252 and Arg1367 of ADAMTS13 comprise a hot-spot for anti-CUB domain antibodies in patients with iTTP. Blood advances. https://doi.org/10.1182/bloodadvances.2025017193

Huckriede, J., Keulen, G. M., van de Poll, M. C. G., Wichapong, K., Reutelingsperger, C. P. M., & Nicolaes, G. A. F. (2025). Proteolytic neutralization of extracellular histones by neutrophil elastase is enhanced by heparin. Journal of Thrombosis and Haemostasis, 23(8), 2483-2493. https://doi.org/10.1016/j.jtha.2025.03.039

Mozaffari, S., Moen, A., Ng, C. Y., Nicolaes, G. A. F., & Wichapong, K. (2025). Structural bioinformatics for rational drug design. Research and practice in thrombosis and haemostasis, 9(1), Article e102691. https://doi.org/10.1016/j.rpth.2025.102691

Bülow Anderberg, S., Huckriede, J., Hultström, M., Larsson, A., de Vries, F., Lipcsey, M., Nicolaes, G. A. F., & Frithiof, R. (2024). Association of corticosteroid therapy with reduced acute kidney injury and lower NET markers in severe COVID-19: an observational study. Intensive Care Medicine Experimental, 12(1), 85. Article 85. https://doi.org/10.1186/s40635-024-00670-3

Keulen, G. M., Huckriede, J., Wichapong, K., & Nicolaes, G. A. F. (2024). Histon activities in the extracellular environment: regulation and prothrombotic implications. Current Opinion in Hematology, 31(5), 230-237. https://doi.org/10.1097/MOH.0000000000000827

Nicolaes, G. A. F., & Soehnlein, O. (2024). Targeting extranuclear histones to alleviate acute and chronic inflammation. Trends in Pharmacological Sciences, 45(7), 651-662. https://doi.org/10.1016/j.tips.2024.05.008

Singh, A., Kraaijeveld, A. O., Curaj, A., Wichapong, K., Hammerich, L., de Jager, S. C. A., Bot, I., Atamas, S. P., van Berkel, T. J. C., Jukema, J. W., Comerford, I., Mccoll, S. R., Mees, B., Heemskerk, J. W. M., Nicolaes, G. A. F., Hackeng, T., Liehn, E. A., Tacke, F., & Biessen, E. A. L. (2024). CCL18 aggravates atherosclerosis by inducing CCR6-dependent T-cell influx and polarization. Frontiers in Immunology, 15, Article 1327051. https://doi.org/10.3389/fimmu.2024.1327051

Reutelingsperger, C. P. M., Gijbels, M. J., Spronk, H., Van Oerle, R., Schrijver, R., Ekhart, P., de Kimpe, S., & Nicolaes, G. A. F. (2024). M6229 Protects against Extracellular-Histone-Induced Liver Injury, Kidney Dysfunction, and Mortality in a Rat Model of Acute Hyperinflammation. International Journal of Molecular Sciences, 25(3), Article 1376. https://doi.org/10.3390/ijms25031376

Arfman, T., Zollet, V., van Es, N., Bosch, F. T. M., Nicolaes, G. A. F., Sorvillo, N., & Voorberg, J. (2024). Elevated levels of citrullinated fibrinogen in patients with cancer. eJHaem, 5(1), 136-140. https://doi.org/10.1002/jha2.825