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… Approval form Formulier 1 pagina 1/1  info-hsb@maastrichtuniversity.nl Versie 1.1 02/2025 Approval as worker with genetically modified and/or pathogenic microorganisms GENERAL DETAILS Family Name First name Employee/student number UM / MUMC 100 / i6 Card number E-mail End date activities Department Supervisor Position technician, student, PhD-student, PhD, PI, Guest, other: EXPERIENCE ON WORKING WITH GMOS/MICROORGANISMS … Techniques) certificate(s): date: institution: PLANNED ACTIVITIES GMO activities No, Yes on GMO permit IG Planned activities on level ML-I, ML-II, D-I, DM-I, DM-II, Plants lev I, Plants lev II Name Date Signature ABV/VM: Explained the GMO rules and procedures Applicant: Understands GMO rules and procedures Watched VROM-video “Exactly right” Name BSO BSO provides consent for working at GMO level: Allowance for viral activities. Date of viral introduction: Date Signature The ABV sends this form …

… will judge the project proposal based on its scientific, 3R’s and ethical merits and will advise the CCD within 20 working days. To expedite this process, the DEC-UM is composed of members with expertise in different scientific areas (see Table 1). Whenever necessary, the DEC-UM asks questions to the responsible researcher for clarification and invites them to the plenary meeting if needed. The CCD will make a decision based on the advice of the DEC and can provide a permit or a disapproval of … License holder The DEC-UM advised the CCD for project proposals from the UM (UM, FHML). In 2020, no project proposals from an external license holder have been judged by the DEC-UM. Activities DEC-UM Meetings The DEC-UM organized 8 – 2 on site and 6 online due to Covid-19 measures – meetings in 2020 to plenarily discuss the CCD requests to provide an advice regarding new project proposals or project amendments. Based on these plenary meetings, the DEC-UM prepared advices for the CCD. The … 1 (both online). The meeting organized by NVDEC always preceded the meetings organized by CCD. In 2020, several members of the DEC-UM have participated in the webinar “Nut & oorzaak dierproeven”, organized by KNAW on June 8 (online) and in the workshop “Openbaarheid informatie over dierproeven”, organized by the Ministry LNV & EZK on September 22 and 29 (both online). Education In the Laboratory Animal Science Course at UM/FHML, organized in June and October 2020, the ethicist DEC-UM gave …

… trends in childhood overweight Tand obesity have been observed.2 An association between asthma and overweight in children has been found in several prospective studies.3 Proposed causal factors for this association include systemic inflammation, mechanical changes associated with high body weight, changes in airway hyperresponsiveness, decreased physical activity, and changes in diet,4 but the exact pathways through which overweight may lead to asthma are currently poorly understood.5 … age 4 years. Since July 2006, all parents of newborn children who live in the study region are invited to participate in LucKi starting at 1-2 weeks after birth. Parents are asked to complete questionnaires at base- line (1-2 weeks after birth) and when their child is aged 7 months, 14 months, and 3 years. The timing of the ques- tionnaires coincides with routine visits. Parents are also asked to provide signed informed consent for extracting additional data from the Child and Youth Health Care … wheezers and nonwheezers: B, �1.23; 95% CI, �2.15 to �0.31), attenuated by age 14 months (B,�0.51; 95% CI,�0.92 to�0.10), and had dis- appeared by age 3 years (B, 0.22; 95% CI, �0.26 to 0.70) (Figure 2). 346 Sensitivity Analyses To check for a nonlinear association between birth weight and the outcome variables wheeze and overweight, we added a centralized quadratic term for birth weight to the univari- able models. The quadratic term was not statistically signifi- cant in any model, and thus …