2022fhml_langie_repairing_obesity.pdf
(493.85 kB, PDF)
… of Human Health and Diseases Team: Prof. FJ van Schooten, Dr. Sabine Langie, Dr. Godschalk Roger; Dep. Pharmacology & Toxicology Key words: base excision repair (BER), cancer, genotype, mitochondria, obesogenic environment The number of obese people is increasing and this cannot be explained solely by excessive consumption and/ or reduced physical activity. Research indicates that weight gain is influenced by interactions between our genes and our environment. In addition, various studies … mice lacking DNA repair-related genes show obesity and features of metabolic syndrome. In humans; carriers of low-activity variant (LV) alleles in DNA repair-related genes showed a higher risk of weight gain and related metabolic disorders. Therefore, we hypothesize that these LVs in DNA repair genes can load the gun, but exposure to obesogenic environmental stressors (increased caloric intake, low physical activity) will pull the trigger of a vicious circle, leading to obesity and …