Early Life Growth and the Development of Preschool Wheeze, Independent from Overweight - The LucKi Birth Cohort Study.pdf
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… C. P. van Schayck, PhD6 Objective To investigate whether birth weight and postnatal growth rates are independently related to the devel- opment of overweight and wheeze up to age 3 years. Study design Children from the LucKi Birth Cohort Study with complete follow-up for repeated questionnaires (at age 0, 7, and 14 months and 3 years) and informed consent to use height and weight data (measured by trained personnel at age 0, 7, and 14 months and 2 and 3 years) were included (n = 566). Wheeze … weight, an indicator of fetal growth andmaturation, and postnatal growth are associated with wheeze/asthma and over- weight. Both low and high birth weight seem to predispose for asthma8,9 and overweight,10-12 although studies report incon- sistent findings. Unfavorable conditions in utero, such as maternal smoking during pregnancy,13 may cause impaired somatic growth and impede lung development, thus explaining the risk of asthma in low birth weight children.9 In addition, low birth From the … choices, such as definition of growth rates and timing of outcome measurements. In our study, growth was defined as difference scores of standardized weight, height, or BMI in 3 periods (age 1-7 months, age 7-14 months, and age 2-3 years), whereas others have cate- gorized growth between age 0 and 2 years21 or in several intermediate periods16-18 into slow, normal, and rapid weight gain, or have used parameters of modeled growth Early Life Growth and the Development of Preschool Wheeze, …