phd_thesis_sylvia_nauta.pdf
(11.97 MB, PDF)
… area-dependent.3 Overall, the incidence of bone fractures is increasing, also due to a growing and aging population.1 The fracture location and incidence change with age and is gender dependent.1,3 Bone fractures are a major health issue, especially when occurring in osteoporotic bone.1,3 The treatment of these bone fractures became more complicated and expensive, also as a result of the aging population.3 A bone fracture is a complete or incomplete break of the anatomical continuation of the bone … achieve a union and return the affected bone to complete functioning.2,57,59,73 Nevertheless, treatment of non-unions is complex and related to high costs.57,71-73 The type and location of non-union in combination with the alignment will dictate the best treatment option.57,71-73 The parameters necessary to achieve are based on the diamond concept: mechanical stability, osteogenic cells, osteoconductive scaffolds, and growth factors, which result in an adequate biological environment when adequate … R, Tsiridis E, Giannoudis PV. Current concepts of molecular aspects of bone healing. Injury. 2005;36(12):1392-404. 8. Giannoudis PV, Einhorn TA, Marsh D. Fracture healing: the diamond concept. Injury. 2007;38 Suppl 4:S3-6. 9. Hak DJ, Fitzpatrick D, Bishop JA, et al. Delayed union and nonunions: epidemiology, clinical issues, and financial aspects. Injury. 2014;45(Suppl 2):S3-7. 10. Tsiridis E, Upadhyay N, Giannoudis P. Molecular aspects of fracture healing: which are the important molecules? …