J. Theys

Stoffels, L. M., Rodriguez, E. S. E., Theys, J., & Shiri-Sverdlov, R. (2026). Revisiting cholesterol metabolism in hepatocellular carcinoma: a hidden driver of systemic therapy response. ESMO Gastrointestinal Oncology, 11, Article 100284. https://doi.org/10.1016/j.esmogo.2025.100284

Vermeulen, I., Li, M., van Mourik, H., Yadati, T., Eijkel, G., Balluff, B., Godschalk, R., Temmerman, L., Biessen, E. A. L., Kulkarni, A., Theys, J., Houben, T., Cillero-Pastor, B., & Shiri-Sverdlov, R. (2025). Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis. FEBS Journal, 292(7), 1781-1797. https://doi.org/10.1111/febs.17358

Westheim, A. J. F., Dubois, L. J., Prades-Sagarra, E., van de Laak, J. G. M., van Mourik, H., Schuitmaker, L., Stoffels, L. M., Yaromina, A., van Dijk, M., van Bergenhenegouwen, J., van Helvoort, A., Langen, R. C. J., Shiri-Sverdlov, R., & Theys, J. (2025). Dietary enrichment with n-3 lc-PUFA-rich fish oil improves preclinical outcome of radiotherapy and anti-PD-L1 combination treatment. Cancer Treatment and Research Communications, 44, Article 100943. https://doi.org/10.1016/j.ctarc.2025.100943

van Mourik, H., Westheim, A., Schneider, C. V., Stoffels, L., Wieczerzak, E., Steeghs, J., Schneider, K. M., Temmerman, L., Biessen, E., Godschalk, R., Theys, J., & Shiri - Sverdlov, R. (2025). Extracellular Cathepsin B Is a potential Therapeutic Target in Hepatocellular Carcinoma. Liver International, 6(1), Article e70016. https://doi.org/10.1002/lci2.70016

Zhang, Y., Cong, Y., Bailey, T. S., Dubois, L. J., Theys, J., & Lambin, P. (2024). Harnessing native-cryptic plasmids for stable overexpression of heterologous genes in Clostridium butyricum DSM 10702 for industrial and medical applications. Microbiological Research, 288, Article 127889. https://doi.org/10.1016/j.micres.2024.127889

van de Worp, W. R. P. H., Theys, J., Wolfs, C. J. A., Verhaegen, F., Schols, A. M. W. J., van Helvoort, A., & Langen, R. C. J. (2024). Targeted nutritional intervention attenuates experimental lung cancer cachexia. Journal of cachexia, sarcopenia and muscle, 15(5), 1664-1676. https://doi.org/10.1002/jcsm.13520

Zhang, Y., Bailey, T. S., Hittmeyer, P., Dubois, L. J., Theys, J., & Lambin, P. (2024). Multiplex genetic manipulations in Clostridium butyricum and Clostridium sporogenes to secrete recombinant antigen proteins for oral-spore vaccination. Microbial cell factories, 23(1), Article 119. https://doi.org/10.1186/s12934-024-02389-y

Theys, J., Patterson, A. V., & Mowday, A. M. (2024). Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery. Molecular Diagnosis & Therapy, 28(2), 141-151. https://doi.org/10.1007/s40291-024-00695-0

Mowday, A. M., van de Laak, J. M., Fu, Z., Henare, K. L., Dubois, L., Lambin, P., Theys, J., & Patterson, A. V. (2024). Tumor-targeting bacteria as immune stimulants - the future of cancer immunotherapy? Critical Reviews in Microbiology, 50(6), 955-970. https://doi.org/10.1080/1040841X.2024.2311653

Zhang, Y., Kubiak, A. M., Bailey, T. S., Claessen, L., Hittmeyer, P., Dubois, L., Theys, J., & Lambin, P. (2023). Development of a CRISPR-Cas12a system for efficient genome engineering in clostridia. Microbiology spectrum, 11(6), Article 0245923. https://doi.org/10.1128/spectrum.02459-23