J. Theys

Schuitmaker, L., van der Wiel, A. M. A., Lieuwes, N. G., Biemans, R., Mutsters, N. A. M., Jung, J., Bastos, V. C., Sagarra, E. P., Kuang, S., Setton, J., Langie, S. A. S., Kampen, K. R., Theys, J., Yaromina, A., Dubois, L. J., & Lambin, P. (2026). Deficiencies in the Fanconi anemia or homologous recombination pathway enhance the antitumor effects of the hypoxia-activated prodrug CP-506. Molecular Therapy: Oncology, 34(1), Article 201161. https://doi.org/10.1016/j.omton.2026.201161

Stoffels, L. M., Rodriguez, E. S. E., Theys, J., & Shiri-Sverdlov, R. (2026). Revisiting cholesterol metabolism in hepatocellular carcinoma: a hidden driver of systemic therapy response. ESMO Gastrointestinal Oncology, 11, Article 100284. https://doi.org/10.1016/j.esmogo.2025.100284

Westheim, A. J. F., Dubois, L. J., Prades-Sagarra, E., Chan, J., van der Wiel, A. M. A., Lieuwes, N. G., Biemans, R., Cong, Y., Houben, T., Meesters, D. M., Yaromina, A., van Dijk, M., van Bergenhenegouwen, J., van Helvoort, A., Langen, R. C. J., Penders, J., Shiri-sverdlov, R., & Theys, J. (2026). The Effect of Dietary Fiber Compositions on the Therapeutic Outcome of Combined Radio- and Immunotherapy in a Preclinical Cancer Model. Molecular Nutrition & Food Research, 70(2), Article e70370. https://doi.org/10.1002/mnfr.70370

Vermeulen, I., Li, M., van Mourik, H., Yadati, T., Eijkel, G., Balluff, B., Godschalk, R., Temmerman, L., Biessen, E. A. L., Kulkarni, A., Theys, J., Houben, T., Cillero-Pastor, B., & Shiri-Sverdlov, R. (2025). Inhibition of intracellular versus extracellular cathepsin D differentially alters the liver lipidome of mice with metabolic dysfunction-associated steatohepatitis. FEBS Journal, 292(7), 1781-1797. https://doi.org/10.1111/febs.17358

Westheim, A. J. F., Dubois, L. J., Prades-Sagarra, E., van de Laak, J. G. M., van Mourik, H., Schuitmaker, L., Stoffels, L. M., Yaromina, A., van Dijk, M., van Bergenhenegouwen, J., van Helvoort, A., Langen, R. C. J., Shiri-Sverdlov, R., & Theys, J. (2025). Dietary enrichment with n-3 lc-PUFA-rich fish oil improves preclinical outcome of radiotherapy and anti-PD-L1 combination treatment. Cancer Treatment and Research Communications, 44, Article 100943. https://doi.org/10.1016/j.ctarc.2025.100943

van Mourik, H., Westheim, A., Schneider, C. V., Stoffels, L., Wieczerzak, E., Steeghs, J., Schneider, K. M., Temmerman, L., Biessen, E., Godschalk, R., Theys, J., & Shiri - Sverdlov, R. (2025). Extracellular Cathepsin B Is a potential Therapeutic Target in Hepatocellular Carcinoma. Liver International, 6(1), Article e70016. https://doi.org/10.1002/lci2.70016

Zhang, Y., Cong, Y., Bailey, T. S., Dubois, L. J., Theys, J., & Lambin, P. (2024). Harnessing native-cryptic plasmids for stable overexpression of heterologous genes in Clostridium butyricum DSM 10702 for industrial and medical applications. Microbiological Research, 288, Article 127889. https://doi.org/10.1016/j.micres.2024.127889

van de Worp, W. R. P. H., Theys, J., Wolfs, C. J. A., Verhaegen, F., Schols, A. M. W. J., van Helvoort, A., & Langen, R. C. J. (2024). Targeted nutritional intervention attenuates experimental lung cancer cachexia. Journal of cachexia, sarcopenia and muscle, 15(5), 1664-1676. https://doi.org/10.1002/jcsm.13520

Zhang, Y., Bailey, T. S., Hittmeyer, P., Dubois, L. J., Theys, J., & Lambin, P. (2024). Multiplex genetic manipulations in Clostridium butyricum and Clostridium sporogenes to secrete recombinant antigen proteins for oral-spore vaccination. Microbial cell factories, 23(1), Article 119. https://doi.org/10.1186/s12934-024-02389-y

Theys, J., Patterson, A. V., & Mowday, A. M. (2024). Clostridium Bacteria: Harnessing Tumour Necrosis for Targeted Gene Delivery. Molecular Diagnosis & Therapy, 28(2), 141-151. https://doi.org/10.1007/s40291-024-00695-0