P.R.A. Heckman

Heckman, P. R. A., Havekes, R., & Blokland, A. (2025). Memory impairments observed after a half night sleep restriction are not mediated by working memory, attention, or inhibitory control mechanisms. Neurobiology of Learning and Memory, 219, Article 108054. https://doi.org/10.1016/j.nlm.2025.108054

Zhao, H., Blokland, A., Prickaerts, J., Havekes, R., & Heckman, P. R. A. (2024). Treatment with the selective PDE4B inhibitor A-33 or PDE4D inhibitor zatolmilast prevents sleep deprivation-induced deficits in spatial pattern separation. Behavioural Brain Research, 459, Article 114798. https://doi.org/10.1016/j.bbr.2023.114798

Blokland, A., Jackson, M., Puustinen, K., Soeterboek, J., & Heckman, P. R. A. (2024). Acute sleep loss impairs object but not spatial pattern separation in humans. Neuroscience Letters, 818, Article 137535. https://doi.org/10.1016/j.neulet.2023.137535

Bolsius, Y. G., Heckman, P. R. A., Paraciani, C., Wilhelm, S., Raven, F., Meijer, E. L., Kas, M. J. H., Ramirez, S., Meerlo, P., & Havekes, R. (2023). Recovering object-location memories after sleep deprivation-induced amnesia. Current Biology, 33(2), 298-308.e5. https://doi.org/10.1016/j.cub.2022.12.006

Nelissen, E., van Hagen, B. T. J., Argyrousi, E. K., van Goethem, N. P., Heckman, P. R. A., Paes, D., Mulder-Jongen, D. A. J., Ramaekers, J. G., Blokland, A., Schmidt, H. H. H. W., & Prickaerts, J. (2022). Soluble guanylate cyclase stimulator riociguat improves spatial memory in mice via peripheral mechanisms. Neuroscience Letters, 788, Article 136840. https://doi.org/10.1016/j.neulet.2022.136840

Heckman, P. R. A., Roig Kuhn, F., Raven, F., Bolsius, Y. G., Prickaerts, J., Meerlo, P., & Havekes, R. (2020). Phosphodiesterase inhibitors roflumilast and vardenafil prevent sleep deprivation-induced deficits in spatial pattern separation. Synapse, 74(6), Article 22150. https://doi.org/10.1002/syn.22150

Argyrousi, E. K., Heckman, P. R. A., & Prickaerts, J. (2020). Role of cyclic nucleotides and their downstream signaling cascades in memory function: Being at the right time at the right spot. Neuroscience and Biobehavioral Reviews, 113, 12-38. https://doi.org/10.1016/j.neubiorev.2020.02.004

Argyrousi, E. K., Heckman, P. R. A., van Hagen, B. T. J., Muysers, H., van Goethem, N. P., & Prickaerts, J. (2020). Pro-cognitive effect of upregulating cyclic guanosine monophosphate signalling during memory acquisition or early consolidation is mediated by increased AMPA receptor trafficking. Journal of Psychopharmacology, 34(1), 103-114. Article 0269881119885262. https://doi.org/10.1177/0269881119885262

Blokland, A., Heckman, P., Vanmierlo, T., Schreiber, R., Paes, D., & Prickaerts, J. (2019). Phosphodiesterase Type 4 Inhibition in CNS Diseases. Trends in Pharmacological Sciences, 40(12), 971-985. https://doi.org/10.1016/j.tips.2019.10.006