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Aart van Apeldoorn (A. A.)

Key publicaties
  • Marchioli, G., Zellner, L., Oliveira, C., Engelse, M., de Koning, E., Mano, J., Karperien, M. B. J., van Apeldoorn, A., & Moroni, L. (2017). Layered PEGDA hydrogel for islet of Langerhans encapsulation and improvement of vascularization. Journal of Materials Science-Materials in Medicine, 28(12), Article 195. https://doi.org/10.1007/s10856-017-6004-6
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  • Skrzypek, K., Nibbelink, M. G., van Lente, J., Buitinga, M., Engelse, M. A., de Koning, E. J. P., Karperien, M., van Apeldoorn, A., & Stamatialis, D. (2017). Pancreatic islet macroencapsulation using microwell porous membranes. Scientific Reports, 7(1), Article 9186. https://doi.org/10.1038/s41598-017-09647-7
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  • Buitinga, M., Assen, F., Hanegraaf, M., Wieringa, P., Hilderink, J., Moroni, L., Truckenmüller, R., van Blitterswijk, C., Roemer, G.-W., Carlotti, F., de Koning, E., Karperien, M., & van Apeldoorn, A. (2017). Micro-fabricated scaffolds lead to efficient remission of diabetes in mice. Biomaterials, 135, 10-22. https://doi.org/10.1016/j.biomaterials.2017.03.031
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  • Nibbelink, M. G., Marchioli, G., Moroni, L., Karperien, M., & Van Apeldoorn, A. (2016). A Protocol to Enhance INS1E and MIN6 FunctionalityThe Use of Theophylline. International Journal of Molecular Sciences, 17(9), Article 1532. https://doi.org/10.3390/ijms17091532
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  • Marchioli, G., van Gurp, L., van Krieken, P. P., Stamatialis, D., Engelse, M., van Blitterswijk, C. A., Karperien, M. B. J., de Koning, E., Alblas, J., Moroni, L., & van Apeldoorn, A. A. (2015). Fabrication of three-dimensional bioplotted hydrogel scaffolds for islets of Langerhans transplantation. Biofabrication, 7(2), Article 025009. https://doi.org/10.1088/1758-5090/7/2/025009
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  • Hilderink, J., Spijker, S., Carlotti, F., Lange, L., Engelse, M., van Blitterswijk, C., de Koning, E., Karperien, M., & van Apeldoorn, A. (2015). Controlled aggregation of primary human pancreatic islet cells leads to glucose-responsive pseudoislets comparable to native islets. In Journal of cellular and molecular medicine (pp. 1836-46) https://doi.org/10.1111/jcmm.12555
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  • Buitinga, M., Portalska, K. J., Cornelissen, D.-J., Plass, J., Hanegraaf, M., Carlotti, F., de Koning, E., Engelse, M., van Blitterswijk, C., Karperien, M., van Apeldoorn, A., & de Boer, J. (2016). Coculturing Human Islets with Proangiogenic Support Cells to Improve Islet Revascularization at the Subcutaneous Transplantation Site. Tissue Engineering, 22(3-4), 375-385. https://doi.org/10.1089/ten.tea.2015.0317
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  • Marchioli, G., Di Luca, A., de Koning, E., Engelse, M., Van Blitterswijk, C. A., Karperien, M., Van Apeldoorn, A. A., & Moroni, L. (2016). Hybrid Polycaprolactone/Alginate Scaffolds Functionalized with VEGF to Promote de Novo Vessel Formation for the Transplantation of Islets of Langerhans. Advanced Healthcare Materials, 5(13), 1606-1616. https://doi.org/10.1002/adhm.201600058
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Recente publicaties
  • Stell, A., Vaithilingam, V., Mohammed, S. G., de Vries, R. H. W., de Bont, D. F. A., de Koning, E. J. P., & van Apeldoorn, A. A. (2025). A hybrid implant combining a macroporous device with immunoprotective microcapsules for cell therapy applications: A conceptual in vitro study. Materials today. Bio, 31, Article 101574. https://doi.org/10.1016/j.mtbio.2025.101574
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  • de Bont, D. F. A., Mohammed, S. G., de Vries, R. H. W., Paulino da Silva Filho, O., Vaithilingam, V., Jetten, M. J., Engelse, M. A., de Koning, E. J. P., & van Apeldoorn, A. A. (2025). Supporting islet function in a PVDF membrane based macroencapsulation delivery device by solvent non-solvent casting using PVP. PLOS ONE, 20(3), Article e0298114. https://doi.org/10.1371/journal.pone.0298114
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  • Tol, M. C., de Vries, R. H. W., Engelse, M. A., Carlotti, F., van Apeldoorn, A. A., de Koning, E. J. P., & Huurman, V. A. L. (2024). Subcutaneous Implantation of Open Microwell Islet Delivery Devices in Pigs. Surgical Innovation. Advance online publication. https://doi.org/10.1177/15533506241306491
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  • de Vries, R., & van Apeldoorn, A. A. (2024). Scaffolds for Encapsulation of Stem Cell-Derived ß Cells. In L. Piemonti, J. Odorico, T. J. Kieffer, V. Sordi, & E. de Koning (Eds.), Pluripotent Stem Cell Therapy for Diabetes (1st ed., pp. 123-149). Springer. https://doi.org/10.1007/978-3-031-41943-0_7
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  • de Vries, R., & van Apeldoorn, A. A. (2024). Selecting Biocompatible Biomaterials for Stem Cell-Derived β-Cell Transplantation. In L. Piemonti, J. Odorico, T. J. Kieffer, V. Sordi, & E. de Koning (Eds.), Pluripotent Stem Cell Therapy for Diabetes (1 ed., pp. 97-121). Springer, Cham. https://doi.org/10.1007/978-3-031-41943-0_6
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  • Abadpour, S., Niemi, E. M., Orrhult, L. S., Hermanns, C., de Vries, R., Nogueira, L. P., Haugen, H. J., Josefsen, D., Krauss, S., Gatenholm, P., van Apeldoorn, A., & Scholz, H. (2023). Adipose-derived Stromal Cells Preserve Pancreatic Islet Function in A Transplantable 3d Bioprinted Scaffold. Advanced Healthcare Materials, 12(32), Article 2300640. https://doi.org/10.1002/adhm.202300640
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  • Tol, M. C., de Bont, D. F. A., Boon, W. P. C., de Koning, E. J. P., & van Apeldoorn, A. A. (2023). Preferred Islet Delivery Device Characteristics and Implantation Strategies of Patients With Type 1 Diabetes. Transplant International, 36(1), Article 11077. https://doi.org/10.3389/ti.2023.11077
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  • Piemonti, L., Scholz, H., de Jongh, D., Kerr-Conte, J., van Apeldoorn, A., Shaw, J. A. M., Engelse, M. A., Bunnik, E., Mühlemann, M., Pal-Kutas, K., Scott, W. E., Magalon, J., Kugelmeier, P., & Berishvili, E. (2023). The Relevance of Advanced Therapy Medicinal Products in the Field of Transplantation and the Need for Academic Research Access: Overcoming Bottlenecks and Claiming a New Time. Transplant International, 36(1), Article 11633. https://doi.org/10.3389/ti.2023.11633
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  • Hermanns, C., da Silva, O. P., Vaithilingam, V., & van Apeldoorn, A. (2022). The Potential of Cell Sheet Technology for Beta Cell Replacement Therapy. Current Transplantation Reports, 9(3), 199-208. https://doi.org/10.1007/s40472-022-00371-4
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  • Stell, A. L., Mohommed, S. G., de Vries, R., Engelse, M. A., de Koning, E., LaPointe, V. L. S., Sthijns, M. M. J. P. E., & Van Apeldoorn, A. A. (2022). A Synthetic Biomaterials Approach To Improve Islet Transplantation. Tissue Engineering, 28, S221-S221.
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