Drs L.E. Hillege, M.D.
Recente publicaties
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Hillege, L. E. (2025). The gut microbiome in breast and colorectal cancer: First steps towards microbiome-targeted interventions. [Doctoral Thesis, Maastricht University]. https://doi.org/10.26481/dis.20250408lhMeer informative over deze publicatie
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Hillege, L. E., Barnett, D. J. M., Ziemons, J., Aarnoutse, R., de Vos-Geelen, J., van Geel, R., de Boer, M., van Riet, Y. E. A., Vincent, J., Penders, J., & Smidt, M. L. (2025). The gut microbiota during tamoxifen therapy in patients with breast cancer. Scientific Reports, 15(1), Article 7874. https://doi.org/10.1038/s41598-025-91734-1Meer informative over deze publicatie
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Hillege, L. E., Stevens, M. A. M., Kristen, P. A. J., de Vos-Geelen, J., Penders, J., Redinbo, M. R., & Smidt, M. L. (2024). The role of gut microbial ß-glucuronidases in carcinogenesis and cancer treatment: a scoping review. Journal of Cancer Research and Clinical Oncology, 150(11), Article 495. https://doi.org/10.1007/s00432-024-06028-2Meer informative over deze publicatie
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Hillege, L. E., Trepka, K. R., Ziemons, J., Aarnoutse, R., Guthrie, B. G. H., de Vos-Geelen, J., Valkenburg-van Iersel, L., van Hellemond, I. E. G., Baars, A., Vestjens, J. H. M. J., Penders, J., Deutschbauer, A., Atreya, C. E., Kidder, W. A., Turnbaugh, P. J., & Smidt, M. L. (2024). Metagenomic analysis during capecitabine therapy reveals microbial chemoprotective mechanisms and predicts drug toxicity in colorectal cancer patients. https://doi.org/10.1101/2024.10.11.24315249Meer informative over deze publicatie
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Ziemons, J., Hillege, L. E., Aarnoutse, R., de Vos-Geelen, J., Valkenburg-van Iersel, L., Mastenbroek, J., van Geel, R., Barnett, D. J. M., Rensen, S. S., van Helvoort, A., Dopheide, L. H. J., Roeselers, G., Penders, J., Smidt, M. L., & Venema, K. (2024). Prebiotic fibre mixtures counteract the manifestation of gut microbial dysbiosis induced by the chemotherapeutic 5-Fluorouracil (5-FU) in a validated in vitro model of the colon. BMC Microbiology, 24(1), Article 222. https://doi.org/10.1186/s12866-024-03384-4Meer informative over deze publicatie
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Dieleman, S., Hillege, L., Ziemons, J., Kooreman, L., Penders, J., Boleij, A., Grabsch, H., & Smidt, M. (2023). Microbiota immuuninteracties bij kankerontwikkeling en behandeling. Nederlands Tijdschrift voor Leefstijlgeneeskunde, 1(4), 177-182. https://www.ntvl.nl/journal-edition/2023-nummer-4-december-2023/Meer informative over deze publicatie
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Ziemons, J., Aarnoutse, R., Heuft, A., Hillege, L., Waelen, J., de Vos-Geelen, J., Iersel, L. V. V., van Hellemond, I. E. G., Creemers, G. J. M., Baars, A., Vestjens, J. H. M. J., Penders, J., Venema, K., & Smidt, M. L. (2023). Fecal levels of SCFA and BCFA during capecitabine in patients with metastatic or unresectable colorectal cancer. Clinical and Experimental Medicine, 23(7), 3919-3933. https://doi.org/10.1007/s10238-023-01048-7Meer informative over deze publicatie
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Hillege, L., Waelen, J., Ziemons, J., Aarnoutse, R., De Vos-Geelen, J., De Boer, M., Van Riet, Y., Vincent, J., Venema, K., Rensen, S., Simpson, J., Redinbo, M., Penders, J., & Smidt, M. (2022). Bacterial beta-glucuronidase activity in postmenopausal breast cancer patients: a pilot study. European Journal of Cancer, 175, S84-S84. https://doi.org/10.1016/S0959-8049(22)01578-7Meer informative over deze publicatie
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Aarnoutse, R., Ziemons, J., Hillege, L. E., de Vos-Geelen, J., de Boer, M., Bisschop, S. M. P., Vriens, B. E. P. J., Vincent, J., van de Wouw, A. J., Le, G. N., Venema, K., Rensen, S. S., Penders, J., & Smidt, M. L. (2022). Changes in intestinal microbiota in postmenopausal oestrogen receptor-positive breast cancer patients treated with (neo)adjuvant chemotherapy. npj Breast Cancer, 8(1), Article 89. https://doi.org/10.1038/s41523-022-00455-5Meer informative over deze publicatie
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Aarnoutse, R., Hillege, L. E., Ziemons, J., De Vos-Geelen, J., de Boer, M., Aerts, E. M. E. R., Vriens, B. E. P. J., van Riet, Y., Vincent, J., van de Wouw, A. J., Le, G. N., Venema, K., Rensen, S. S., Penders, J., & Smidt, M. L. (2021). Intestinal Microbiota in Postmenopausal Breast Cancer Patients and Controls. Cancers, 13(24), Article 6200. https://doi.org/10.3390/cancers13246200Meer informative over deze publicatie