The enthesis structure with reversed gradients of mineral and collagen that make up the 4 zones from the ligament/tendon to the bone. Especially, the hard-to-soft tissue transition is hard to regenerate.
Niet ge- definieerd

cBITE

Selected publications

Font Tellado S, Chiera S, Bonani W, Poh PSP, Migliaresi C, Motta A, Balmayor ER, van Griensven M. Heparin functionalization increases retention of TGF-β2 and GDF5 on biphasic silk fibroin scaffolds for tendon/ligament-to-bone tissue engineering. Acta Biomater. 2018; 72: 150-166.
https://www.ncbi.nlm.nih.gov/pubmed/29550439    

Kelch S, Balmayor ER, Seeliger C, Vester H, Kirschke JS, van Griensven M. miRNAs in bone tissue correlate to bone mineral density and circulating miRNAs are gender independent in osteoporotic patients. Sci Rep. 2017; 7(1): 15861.
https://www.ncbi.nlm.nih.gov/pubmed/29158518  

Seeliger C, Balmayor ER, van Griensven M. miRNAs Related to Skeletal Diseases. Stem Cells Dev. 2016; 25(17):1261-1281
https://www.ncbi.nlm.nih.gov/pubmed/27418331   

Font Tellado S, Balmayor ER, van Griensven M. Strategies to engineer tendon/ligament-to-bone interface: Biomaterials, cells and growth factors. Adv Drug Deliv Rev. 2015; 94:126-140.
https://www.ncbi.nlm.nih.gov/pubmed/25777059  

Seeliger C, Karpinski K, Haug AT, Vester H, Schmitt A, Bauer JS, van Griensven M. Five freely circulating miRNAs and bone tissue miRNAs are associated with osteoporotic fractures. J Bone Miner Res. 2014; 29(8): 1718-1728.
https://www.ncbi.nlm.nih.gov/pubmed/24431276  

 

Read the complete list of publications.
Instructive Biomaterials Engineering
Niet ge- definieerd

IBE

Selected publications

De Melo Pereira D, Habibovic P, Biomineralization-inspired material design for bone regeneration, Advanced Healthcare Materials, 2018. 7(22):e1800700
https://www.ncbi.nlm.nih.gov/pubmed/30240157   

Barata D, Provaggi E, van Blitterswijk CA, Habibovic P, Development of a microfluidic platform integrating high-resolution microstructured biomaterials to study cell-material interactions, Lab on a Chip 2017. 17(23):4134-4147. 
https://www.ncbi.nlm.nih.gov/pubmed/29114689  

Danoux C, Koçer G, Tahmasebi Birgani Z, Barata D, Barralet JE, van Blitterswijk CA, Truckenmüller R, Habibovic P, Development of highly functional biomaterials by decoupling and recombining material properties, Advanced Materials, 2016; 28(9): 1803-1808
https://www.ncbi.nlm.nih.gov/pubmed/26689847   

Yuan H, Fernandes H, Habibovic P, de Boer J, Barradas AM, de Ruiter A, Walsh WR, van Blitterswijk CA, de Bruijn JD.
“Osteoinductive ceramics as a synthetic alternative to autologous bone grafting.” 
Proceedings of the National Academy of Sciences USA, 2010, 107, 13614–13619.
http://dx.doi.org/10.1073/pnas.1003600107   

Habibovic P, Bassett DC, Doillon CJ, Gerard C, McKee MD and Barralet JE.
“Collagen mineralization in vivo by sustained release of inorganic phosphate ions.” 
Advanced Materials, 2010, 22, 1858–1862. 
http://dx.doi.org/10.1002/adma.200902778   

 

Read the complete list of publications.
Complex Tissue Regeneration
Niet ge- definieerd

CTR

Selected publications

Moroni L, Burdick JA, Highley C, Lee SJ, Morimoto Y, Takeuchi S, Yoo JJ. Biofabrication Strategies for 3D In Vitro Models and Regenerative Medicine. Nature Reviews Materials 2018 3(5). 
​https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586020/   

Hendrikson WJ, Rouwkema J, Clementi F, van Blitterswijk CA, Fare S, Moroni L. Towards 4D printed scaffolds for tissue engineering: exploiting 3D shape memory polymers to deliver time-controlled stimulus on cultures cells. Biofabrication 2017, 9(3), 031001. 
https://www.ncbi.nlm.nih.gov/pubmed/28726680   

Gunnewiek MK, Di Luca A, Bollemaat HZ, van Blitterswijk CA, Vancso GJ, Moroni L, Benetti EM. Creeping Proteins in Microporous Structures: Polymer Brush-Assisted Fabrication of 3D Gradients for Tissue Engineering. Adv Healthc Mater 2015, Jun 3;4(8):1169-74.
https://www.ncbi.nlm.nih.gov/pubmed/25676461  

Ramos T, Ahmed M, Wieringa P, Moroni L. Schwann Cells Promote Endothelial Cell Migration. Cell Adh Migr. 2015 Nov 2;9(6):441–51.
https://www.ncbi.nlm.nih.gov/pubmed/26491999  

Leferink A, Schipper D, Arts E, Vrij E, Rivron N, Karperien M, Mittmann K, van Blitterswijk C, Moroni L, Truckenmüller R. Engineered Micro-Objects as Scaffolding Elements in Cellular Building Blocks for Bottom-Up Tissue Engineering Approaches. Advanced Materials 2014, 26(16): 2592-9.  
https://www.ncbi.nlm.nih.gov/pubmed/24395427  

 

Read the complete list of publications.
  • cBITE

    Dit is er niet
  • IBE

    Dit is er niet
  • CTR

    Dit is er niet