Systems BioMedicine
Projects within this theme aim to increase our understanding of chronic diseases related to metabolism, such as obesity, diabetes, heart failure, ageing and immune function, and to develop new, biology-based, personalised approaches to prevent and treat them.
Biological expertise on metabolism, gene regulation and chronic diseases is combined with a broad spectrum of modelling approaches such as dynamic models, network- and pathway biology, and machine learning/AI and statistical inference.
People
- Ilja Arts - digital twins, personalised health, molecular epidemiology, biomarkers, obesity, diabetes, metabolomics, gut microbiota
- Michiel Adriaens - multi-omics, metabolic modelling, regulatory genomics, heart failure, personalised nutrition, machine learning
- Marian Breuer - metabolic modelling, metabolic networks, omics data integration, ageing
- Martina Summer - Kutmon - Network biology, pathway modelling, bioinformatics, multi-omics data analysis, immunometabolism
Projects
- SOPHIA Stratification of Obese Phenotypes to Optimize Future Obesity Therapy
- Glucose control in relation to Mental And Physical Performance and well-beING – TiFN-TKI Agro & Food
- Metabolic modelling of postprandial glucose dynamics and its modulation by diet and physical activity: the role of amino acids - NWO
- Early life effects of human milk oligosaccharides and prebiotics on antibiotic associated gut microbiota changes and health - CCC Carbobiotics
- PREVENTOMICS Empowering consumers to PREVENT diet-related diseases through OMICS sciences
- Metabolic Adaptation, Transitions and Resilience in Overweight individualS (MATRyOSka) - NWO Complexity in Health and Nutrition
- Novel technologies to analyse multilevel high-dimensional time-series challenge test data - Enabling Technologies Hotels
- WikiPathways
- COVID19 Disease Maps project
- ZonMW COVID 19 project - WikiPathways as a platform for COVID-19 pathway models
- Metabolic modelling of the loss of metabolic flexibility in the failing heart – NWO