Rodrigo. Mancilla Fuentes
PhD student at Maastricht University - Nutrition and Movement Sciences Department. Currently working at the Diabetes and Metabolism Research Group (www.drmg.nl) under the supervision of Prof. Matthijs Hesselink and Dr. Vera Schrauwen-Hiderling.
Rodrigo is originally from Chile, where he pursued his bachelor and first master studies. In 2014 he obtained a Scientific award from the scentific commission of Chile to pursue a second master program at Maastricht University, on which he was involved in a project about the in vivo analysis of diurnal variations of water content and lipid content in human liver tissue. One year later, Rodrigo obtained a second scientific award to pursue his PhD studies at Maastricht Univeristy.
The main research interest of Rodrigo is related with exercise metabolism and insulin sensitivity in humans. He focuses on the ability of exercise training to remodel skeletal muscle function and structure, promoting skeletal muscle glucose uptake and restoring intracellular glucose handling (storage and oxidation).
Currently he is performing two human clinical studies:
1) The first is an exercise training-based study wich aims to improve skeletal muscle insulin sensitivity and mitochondrial function in obese pre-type 2 diabetic subjects. Specifically, this study primary targets to restore the ability to store glucose as glycogen in skeletal muscle. In addition, this study also focuses on liver fat content and muscle metabolism during exercise in vivo.
2) The second study aims to assess the ability of activate mitochondrial function upon acute exercise (mitochondrial inertia phenomenon) in trained and sedentary subjects, measuring several muscle metabolites and muscle tissue oxygen consumption in vivo.
- Human energy metabolism
- Skeletal muscle insulin sensitivity
- Whole body glucose homeostasis
- Exercise physiology
- Skeletal muscle mitochondrial function/activation
For these expertises, Rodrigo performs:
- Hyperinsulinemic-euglycemic clamps
- Muscle biopsies at restig and post-insulin stimulation
- Magnetic Resonance Spectroscopy/Imagining (MRS/MRI)
- Indirect calorimetry at resting and during exercise.
Professional career history
MSc Human Movement Sciences, Maastricht Univerity
- Thesis: Diurnal variations in the human liver: an in vivo approach
PhD student, Maastricht University, Nutrition and Movement Sciences department.
Diabetes and Metabolism Research Group