Systems Toxicology

In the domain of systems toxicology we aim to improve our understanding of the molecular mechanisms of health and disease particularly linked to the exposure to chemical compounds.

At MaCSBio, we aim to develop and apply new approaches to extract this information in order to improve our understanding of toxicological processes. This can contribute to the more accurate prediction of toxicity, advancement of drug development, chemical safety assessment and identification of potential molecular targets for interventions. In our studies we typically use combined data from in in vitro investigations of human (patient-derived) cell models, and human population studies.

People

Theo de Kok - toxicogenomics, predictive toxicology, translational and cross omics integration, personalized prevention

Projects

Complex Systems Framework for Non-alcoholic fatty liver disease (NAFLD); NWO Complexity in Health and Nutrtion
Ontology-driven and artificial intelligence based repeated dose toxicity testing of chemicals for next generation risk assessment. EU horizon Europe funded
Virtual Human Platform for safety assessment without the use of animals (VHP4safety); NWO – National Science Agenda
Sustainable food systems (FOODSY); Seed grant UM: Call Seed Fund for Sustainability Research Spearheads
Modelling the dynamics in time-series of toxicogenomics data; PhD project MaCSBio under the SYSTOPP project (SYStems biology approach TOwards targeted Personalized Prevention of chronic diseases).