Pathophysiology of Disease
Full course description
During the course, an introduction to normal immune system physiology will be given in the form of overview lectures to ensure the same (bachelor) level of knowledge. In addition, during weeks 2 to 7, the focus will also be on understanding inflammation and pathophysiology. Every week has a different theme and the students will be challenged with different diseases where immune system dysregulation plays a role. Students will be given their weekly assignments at the beginning of each week, with a prediscussion session where the expected learning goals of the week will be outlined. Thereafter, they will start pre-discussing a case in smaller groups. During the week, they will have expert lectures, e.g. workshops, technical and practical/training skills and journal club discussions. Time will be given for self-study during the week, for both team and individual work. At the end of the week the students will discuss the case they have been working on and the practical/training skill assignment. Theme week 1 Introduction to the immune system: normal physiology.Theme week 2 Immunity to bacteria Theme week 3 Immunity to viruses Theme week 4 Sterile inflammation and other pathological threats Theme week 5 Immunity to tumors Theme week 6 Hypersensitivity disorders and autoimmunity Theme week 7 Microbe-host interactions in (immune) homeostasis Theme week 8 Project discussions, posters and exam
B-ILO1202.1 Explain immunity to microbes and viruses a) Recognize and compare innate and adaptive immunity to extracellular and intracellular bacteria and viruses. b) Explain immune evasion by extracellular and intracellular bacteria and viruses. c) Know how the functional output of the microbiota regulates metabolic and immune homeostasis d) Recognize microbial dysbiosis and its role in immune-mediated disease predisposition b) Recognize the induction of (innate) immune responses by microbes at mucosal interfaces a) Discuss interplay between microbial colonization and the development of the immune system/induction of tolerance B-ILO1202.5 Explain microbe-host interactions in (immune) homeostasis c) Explain IgE and mast cell-dependent reactions and allergic reactions in humans: pathogenesis and therapy. b) Discuss immunological diseases, their pathogenesis and current therapy. a) Recognize diseases caused by antibodies against membrane receptors and extracellular antigens, immune-complex mediated diseases and disease caused by T-lymphocytes. B-ILO1202.4 Explain hypersensitivity disorders and autoimmunity d) The role of the immune system in promoting tumor growth/tumor progression. c) Effect of the tumor microenvironment on anti-tumor immune responses. b) Explain evasion of the immune response by tumors.a) Differentiate tumor immunity, tumor antigens and immune response to tumors. B-ILO1202.3 Explain immunity to tumors b) Discuss pathological threats such as neurodegeneration, atherosclerosis, and metabolic inflammation. a) Analyze the role of sterile inflammation in trauma and ischemia–reperfusion. B-ILO1202.2 Explain sterile inflammation and other pathological threats c) Discuss injurious effects of immune responses to extracellular bacteria: inflammation, septic shock.
- Immunobiology Janeway and Travis 8th edition - Control of Metastasis by NK Cells, López-Soto A1, Gonzalez S2, Smyth MJ3, Galluzzi L4. Cancer Cell. 2017 Aug 14;32(2):135-154 - Exosomes in cancer: Use them or target them? Bastos N, Ruivo CF, da Silva S, Melo SA. Semin Cell Dev Biol. 2017 Aug 11 - Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease. Pickard JM, Zeng MY, Caruso R, Núñez G. Immunol Rev. 2017 Sep;279(1):70-89. - Host-microbiota interactions and adaptive immunity. McCoy KD, Ronchi F, Geuking MB. Immunol Rev. 2017 Sep;279(1):63-69. - Regulation of inflammation by microbiota interactions with the host. Blander JM, Longman RS, Iliev ID, Sonnenberg GF, Artis D. Nat Immunol. 2017 Jul 19;18(8):851-860. - Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System. Postler TS, Ghosh S. Cell Metab. 2017 Jul 5;26(1):110-130. - Chan YK, Gack MU. Viral evasion of intracellular DNA and RNA sensing. Nat Rev Microbiol. 2016;14(6):360-73. - Christensen MH, Paludan SR Viral evasion of DNA-stimulated innate immune responses. Cell Mol Immunol. 2017;14(1):4-13. - Ivashkiv LB, Donlin LT Regulation of type I interferon responses. Nat Rev Immunol. 2014;14(1):36-49. - Orzalli MH, Knipe DM. Cellular sensing of viral DNA and viral evasion mechanisms. Annu Rev Microbiol. 2014;68:477-92. - Levinson W. Review of medical microbiology and immunology (12th ed., Lange medical books). Part II/VII - Benoit et al. J Immunol 2008. Macrophage polarization in bacterial infections - Mege et al. Curr Opin Inf Dis 2011. Macrophage polarization in bacterial infections - Netea et al. Science 2016. Trained immunity: a program of innate immune memory in health and disease. - Guilliams Nat Rev Immunol 2017. Does Niche competition determine the origin of tissue-resident macrophages? - de Oliveira et al. Nat Reve Immunol 2016. Neutrophil migration in infection and wound repair: going forward in reverse.