The Basic Principles of Pharmacology
Full course description
The module’s subjects will be provided in an integrative setting of PBL cases, lectures and practical trainings. The PBL cases will be ammended by lectures which also hook up with topics of this module and prior modules. The presentation of a real patient case illustrates how pharmacology is implemented in clincal practice. An important part of this module consists of a practical in which students perform a clinical trial on the effects of nutrients on the kinetics of a drug. This practical will be completed by an assignment. The results of all other practicals will be presented and discussed in the tutorial group meetings enabling their seamless embedding in the other block's subjects. This module provides an introduction into the basic principles of pharmacology and toxicology. Pharmacology and toxicology deal with the effects of biologically active compounds on (patho)physiological processes.
The disciplines are subdivided into two general subjects: (1) pharmacodynamics, which assesses the effects of a compound in the human physiology, and (2) pharmacokinetics, which assesses the fate of a compound in the human body. Both subjects determine the therapeutic effectivity and toxicity of a drug in humans and are influenced by genetic factors like polymorphisms in genes of drug metabolizing enzymes and by the concomitant intake of nutrients. Also subjects like drug development (preclinical and clinical phases) and the set-up of a clinical trial protocol for medical-ethical approval are covered.
The student is able to:
- describe the basic principles of pharmacodynamics, pharmacokinetics and drug development.
- explain the effects of nutrients and genetic polymorphisms on the action of drugs.
- calculate basic pharmacodynamic and pharmacokinetic parameters and to use them for the prediction of drug action.
- discuss the design and execution of clinical trials to investigate the efficacy of drugs.
- evaluate clinical trial data and present them to qualified persons so that they can follow and understand the outcomes and conclusions.
- Module manual "The Basic Principles of Pharmacology"
- H.P. Rang and M.M. Dale: Pharmacology. 8 and 9th edition, Elsevier, 2015/19. Several copies are available at the library's "study landscape". The book is online accessible via clincalkeys.com.
- B.G. Katzung and A. J. Trevor: Basic and clinical pharmacology. 13th edition, Mc Graw Hill, 2015. Accessible online via accessmedicine.mhmedical.com
- Goodman & Gilman`s: The pharmacological basis of therapeutics. 13th edition. Mc Graw Hill 2017 Accessible online via accessmedicine.mhmedical.com
- Relevant medical books on human anatomy, physiology and pathophysiology available in the liberary's "study landscape" or online via accessmedicine.mhmedical.com
- Search engines such as PubMed to find up-to-date scientific (review) articles.