Full course description
What makes a material a biomaterial? The overall objective of the course Biomaterials is for the student to gain insight in the role that properties of materials can play in solving biomedical problems. Relevant questions in this context are: which requirements need to be met to render a material suitable for biomedical applications? Which biomedical problem is to be solved, and which material offers the best solution? What is the current state-of-the-art? What are the most promising developments?
A biomaterial is defined as “any substance or combination of substances, other than drugs, synthetic or natural in origin, which can be used for any period of time, which augments or replaces partially or totally any tissue, organ or function of the body, in order to maintain or improve the quality of life of the individual”. In this course, the exact structure and physico-chemical characteristics of various biomaterials (metals, ceramics, polymers, composites) will be explained. For instance, the composition, degradation behavior and mechanical properties are important parameters. The working principles of the processing techniques commonly used to modify a raw biomaterial to develop a clinical product will be explained. The techniques that are used to evaluate the physico-chemical characteristics of biomaterials are, consequently, an important subject. Furthermore, the interactions between different biomaterials and the biological environment (cells, extracellular matrix, tissues, organs) will be studied. The concepts of biocompatibility, bioinertness and bioactivity will be introduced, as well as various methods used to determine the biological response to a biomaterial. The translational pathway of each group of biomaterials will be explained highlighting the complex implementation necessary to bring a product to the clinics.
- To provide an overview of all materials that are used in biomedical applications.
- To understand the synthesis and structure of different biomaterials; metals, ceramics, polymers, and composites thereof.
- To introduce the student to the evaluation, characterization, and testing of biomaterials.
- To introduce the student to the selection of processing techniques and their working principles.
- To provide a detailed understanding of the interaction of biomaterials with surrounding tissues and the complete organism.
- Translational pathway of the different biomaterials to clinical applications.
- CHE2001 Organic Chemistry
- Biomaterials Science: An Introduction to Materials in Medicine ISBN 9780123746269 (hardcover), ISBN 9780080877808 (eBook). Ebook available Maastricht University library.