Analytical Science and Technology
Full course description
The emphasis of this course will be on a number of essential topics in analytical sciences and related to modern bio- and polymer chemistry, chemical- and biotechnological engineering. It will introduce the basisc of analytical technologies, and will touch on the basic physical chemical properties of molecules in different phases. The translation of these properties to the capability of modern separation and detection technologies will be made. In the final part, of the course focuses on the so-called hyphenation of the analytical technologies (e.g. LC-MS/MS) and their application in chemical and biological sciences, together with the basics of analytical statistics and method development. Typical topics in the course are based on the quantification and molecular structure assessment of chemical, biological relevant metabolites, bio- and synthetic polymers. In the end the students should be able to design a analytical methodology on basis of their gained knowledge.
- To gain an understanding of the basics in analytical sciences & technologies, molecular structures, their physico chemical properties the importance for the design of analytical methodologies.
- Create a fundamental understanding in “sampling, storage and sample pre-treatment” in the quantification of target compounds, together with a basic knowledge of analytical statistics.
- Insight into fundamental mechanisms of separation technologies (chromatography & electrophoresis), and correlate the “physico chemical properties of molecules to the “mode of action” in gas- super critical and liquid chromatography, CE, FFF and UAC.
- To obtain an understanding of the fundaments in spectroscopic technologies, including UV/VIS, IR/Raman, Fluorescence, Phosphorescence, MS and NMR.
- To become familiar with quantification and molecular structure analysis of chemicals, metabolites, bio- and synthetic polymers using hyphenated technologies, e.g. LC- flow-NMR.
- Obtain insight into different applications of analytical methodologies and acquire sufficient background for more advanced courses in chemical synthesis, polymer-, bio-chemistry and life.
- To gain insight in “Process Analytical Technologies” applied by in-, at and on-line detection technologies, regulatory requirements. Application of advanced technologies in (micro) flow-chemical reactors.
CHE2001 Organic Chemistry and CHE2004 Spectroscopy
Fundamentals of Analytical Chemistry, Skoog (ed. 2014), power point slides, articles to be distributed.