Biomedical Brain Imaging
Full course description
Imaging technologies provide powerful insights into the distribution, binding, and other biological effects of pharmaceuticals. Imaging techniques enable direct assessment of the relationship between drug plasma concentration and target occupancy. Neuroimaging thus enables to possibility to test whether a new chemical entity reaches brain target tissue in sufficient amounts to be pharmacologically active. Therefore, neuroimaging can yield important biomarkers and surrogate endpoints during assessment of disease progression and treatment outcome.
Using the available literature, student presentations, and lectures, students will be able to understand and explain:
- The basic principles of various brain imaging methods (PET, SPECT, MRI, Optical Imaging, MRS)
- How these approaches are used in clinical drug development stages (target identification, distribution, pharmacokinetics, target binding, drug efficacy, safety, personalized medicine)
- Opportunities and challenges of biomedical imaging techniques during the different phases of drug development will be discussed.
- D.M.J. Hernaus