Electrophysiology: From Single Cell Activity to ‘Cognitive’ Markers
Full course description
Our brain is busy all the time, whether we are awake or asleep. There are thousands of neurons which are in constant communication with each other. Neurotransmitters and electrical currents convey information from one cell to another, which in turn produces electrical signals. This course is an introduction into the field of brain electricity. Students first learn about how currents develop (i.e., role of molecules, ion channels or membrane) and how they can be measured (e.g., patch clamp or single-cell recording). Next, discussions focus on how these currents are perceived in electrophysiology. Students also determine what the differences are in measurements using various species. For instance, can electrodes be placed in humans using the same approach that is used for rats? Finally, students will learn what these currents mean in terms of e.g., event-related potentials or (de)synchronisation measures. In addition to the theoretical basis, students will discuss some of the practical issues when performing electrophysiological recordings, such as measurement settings and electrode positions. This is accompanied by the presentation of pictures and short videos on how measurements in animals and humans are performed.
- can explain neuronal electrochemical processes, patch clamp measurements and single-neuron recording techniques;
- can interpret event-related potentials from various species, EEG frequencies, event-related (de)synchronisation, and source localization;
- can design electrophysiological studies with a link to (psycho)pharmacology;
- have basic understanding of how EEG is measured.