Digestion and Defence II
Full course description
There are three main themes in this block: Gastroenterology, Infectiology, Immunology, and Health Law. It forms the bridge between ‘Digest and defense year 1’ (block 1.5) and the cluster abdomen year 3. Year one extensively dealt with normal anatomy and physiology of the digestive tract and the basic principles of microbiology and immunology. Year 3 will mainly deal with clinical reasoning, differential diagnosis, probability diagnosis and therapy. In order to be well prepared for this, year 2 will focus on pathophysiology. Selected clinical presentations will be used to discuss the most important principles and concepts of gastroenterology, infectiology and immunology, starting from the basic knowledge of physiology and anatomy obtained in year 1. The use of illness scripts (pattern recognition of disease) will be introduced as a basis for clinical reasoning. Where applicable, pathophysiological concepts will be reduced to different mechanisms of disease. Discussing pathophysiological concepts in the context of mechanisms of disease in the tutorial group will be an excellent preparation for clinical reasoning leading to differential diagnosis. Knowledge of the basis sciences is indispensable. Therefore, it is mandatory to refresh the knowledge from the block ‘Digest and defense year 1’ before the pre-discussion of each new case or task. There will be ample attention to psychosocial themes such as chronicity, ethics (organ transplant) and public health (outbreak management of infectious disease). The major procedure in the tutorial group will be PBL, incidentally in a multimedia approach. Activities in the tutorials will be supported by lectures, practicals and skills training, taking care of the best possible mutual consistency.
• Explaining clinical symptoms of the most important diseases of the gastrointestinal system using (patho)physiological concepts • Psychosocial and ethical aspects of selected diseases (addiction, chronicity) • Cause and consequence of auto-immunity (general, with a projection on the gastrointestinal system) • Microbiological en immunological aspects of major bacterial, viral, parasitological and opportunistic infections related to clinical presentation • Antibiotics en resistence • Global aspects of serious infections; import diseases • hypersensitivity/allergy
Mescher and Junqueira. Junqueira’s basic histology; 12th ed. Boron & Boulpaep. Medical Physiology. 2nd ed. Marieb, Hoehn. Human Anatomy & Physiology, 8th ed. I Primal pictures (e-book available via e-reader) Guyton and Hall: Textbook of Medical Physiology; 11th ed Devlin. Textbook of Biochemistry; 7th ed Berg & Stryer. Biochemistry Smith and Morton. The Digestive System; 1st ed. Yamada. Textbook of Gastroenterology; 5th ed Robbins and Cotran. Pathologic basis of disease; 8th ed Chandrasoma & Taylor. Concise Pathology 3rd ed. E-book UM library Murray. Medical Microbiology; 6th ed Levinson & Jawetz. Medical Microbiology and Immunology; 7th edition Abbas & Lichtman, Basic Immunology; 3d ed 2008 The Universal Declaration of Human Rights. www.un.org International Health Law (David Townend)