Drug Metabolism and Safety
Full course description
This course provides an insight into human drug metabolism at the molecular and cellular level, from pharmacological to toxic levels, and drug safety evalution processes, ranging from insight into the current safety regulations to novel concepts in safety assessment based on scientific innovations in cell models to replace test animals and in-silico-tools recently developed for a better prediction of drug safety before market introduction. It will also focus on the advantages of personalized medicine, pharmacokinetics and toxicogenomics. It will provide insight into how to extract relevant information such as dose finding and pharmacokinetics, from toxicological datasets (PredTox, TG-GATEs, diXa) and how this can be used to predict (un)safety, related mechanisms and unwanted side effects of different drugs.
Students will be able to understand:
- pharmacokinetics, drug metabolism, dose finding, ADME concept;
- toxicology, toxicogenomics drug safety evaluation, regulatory requirements.
- detection of the differential toxic effects on neuronal cells based on gene expression detected by PCR.