Drug Discovery & Development Project Management
Full course description
A key component of every discovery project is the so-called ‘progression scheme’. The stages of such a scheme typically consists of a series of activities, such as target identification and hit finding, with corresponding milestones, such as target selection and the selection of hits. Selection of the right assays, tests and models, and the implementation of relevant criteria for compounds to pass to the next stage is essential for the success of a discovery project. As is management of the compound flow through the various stages.
In this hands-on course, the elements of the progression scheme will be explained and how the different activities are connected with each other. Subsequently, students will work in small teams to develop a progression scheme for a defined CNS discovery project. Activities and timelines will be recorded in a simplified Gantt chart. Every team will present their scheme at the end of the workshop.
Students will be able to understand:
- progression scheme;
- target identification & selection;
- target assessment & validation;
- hit finding & identifcation; high throughput screening;
- lead finding & selection;
- nomination preclinical development candidate;
- Proof of Mechanism & Proof of Concept;
- behavioral models for CNS diseases;
- project management, multidisciplinary teams;
- Gantt chart.