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Casas, A. I., Geuss, E., Kleikers, P. W. M., Mencl, S., Herrmann, A. M., Buendia, I., Egea, J., Meuth, S. G., Lopez, M. G., Kleinschnitz, C., & Schmidt, H. H. H. W. (2017). NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage. Proceedings of the National Academy of Sciences of the United States of America, 114(46), 12315-12320. https://doi.org/10.1073/pnas.1705034114

Aguirre-Plans, J., Pinero, J., Menche, J., Sanz, F., Furlong, L. I., Schmidt, H. H. H. W., Oliva, B., & Guney, E. (2018). Proximal Pathway Enrichment Analysis for Targeting Comorbid Diseases via Network Endopharmacology. Pharmaceuticals, 11(3), [61]. https://doi.org/10.3390/ph11030061

Gray, S. P., Jha, J. C., Kennedy, K., van Bommel, E., Chew, P., Szyndralewiez, C., Touyz, R. M., Schmidt, H. H. H. W., Cooper, M. E., & Jandeleit-Dahm, K. A. M. (2017). Combined NOX1/4 inhibition with GKT137831 in mice provides dose-dependent reno- and atheroprotection even in established micro- and macrovascular disease. Diabetologia, 60(5), 927-937. https://doi.org/10.1007/s00125-017-4215-5

Kleinschnitz, C., Mencl, S., Kleikers, P. W. M., Schuhmann, M. K., Lopez, M. G., Casas, A. I., Surun, B., Reif, A., & Schmidt, H. H. H. W. (2016). NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage. Journal of Cerebral Blood Flow and Metabolism, 36(9), 1508-1512. https://doi.org/10.1177/0271678X16657094

Gray, S. P., Di Marco, E., Kennedy, K., Chew, P., Okabe, J., El-Osta, A., Calkin, A. C., Biessen, E. A. L., Touyz, R. M., Cooper, M. E., Schmidt, H. H. H. W., & Jandeleit-Dahm, K. A. M. (2016). Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling. Arteriosclerosis Thrombosis and Vascular Biology, 36(2), 295-307. https://doi.org/10.1161/ATVBAHA.115.307012

Casas, A. I., Dao, V. T-V., Daiber, A., Maghzal, G. J., Di Lisa, F., Kaludercic, N., Leach, S., Cuadrado, A., Jaquet, V., Seredenina, T., Krause, K. H., Lopez, M. G., Stocker, R., Ghezzi, P., & Schmidt, H. H. H. W. (2015). Reactive Oxygen-Related Diseases: Therapeutic Targets and Emerging Clinical Indications. Antioxidants & Redox Signaling, 23(14), 1171-1185. https://doi.org/10.1089/ars.2015.6433

Kleikers, P. W. M., Hooijmans, C., Goeb, E., Langhauser, F., Rewell, S. S. J., Radermacher, K., Ritskes-Hoitinga, M., Howells, D. W., Kleinschnitz, C., & Schmidt, H. H. H. W. (2015). A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation. Scientific Reports, 5, [13428]. https://doi.org/10.1038/srep13428

Kleinschnitz, C., Grund, H., Wingler, K., Armitage, M. E., Jones, E., Mittal, M., Barit, D., Schwarz, T., Geis, C., Kraft, P., Barthel, K., Schuhmann, M. K., Herrmann, A. M., Meuth, S. G., Stoll, G., Meurer, S., Schrewe, A., Becker, L., Gailus-Durner, V., ... Schmidt, H. H. H. W. (2010). Post-Stroke Inhibition of Induced NADPH Oxidase Type 4 Prevents Oxidative Stress and Neurodegeneration. Plos Biology, 8(9), [e1000479]. https://doi.org/10.1371/journal.pbio.1000479

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Schmidt, H. H. H. W., & Feelisch, M. (2019). Red Blood Cell-Derived Nitric Oxide Bioactivity and Hypoxic Vasodilation To beta 93 or not to beta 93? Circulation, 139(23), 2664-2667. https://doi.org/10.1161/CIRCULATIONAHA.119.040423

Elbatreek, M. H., Pachado, M. P., Cuadrado, A., Jandeleit-Dahm, K., & Schmidt, H. H. H. W. (2019). Reactive Oxygen Comes of Age: Mechanism-Based Therapy of Diabetic End-Organ Damage. Trends in Endocrinology and Metabolism, 30(5), 312-327. https://doi.org/10.1016/j.tem.2019.02.006

Casas, A. I., Hassan, A. A., Larsen, S. J., Gomez-Rangel, V., Elbatreek, M., Kleikers, P. W. M., Guney, E., Egea, J., Lopez, M. G., Baumbach, J., & Schmidt, H. H. H. W. (2019). From single drug targets to synergistic network pharmacology in ischemic stroke. Proceedings of the National Academy of Sciences of the United States of America, 116(14), 7129-7136. https://doi.org/10.1073/pnas.1820799116

Casas, A. I., Kleikers, P. W. M., Geuss, E., Langhauser, F., Adler, T., Busch, D. H., Gailus-Durner, V., de Angelis, M. H., Egea, J., Lopez, M. G., Kleinschnitz, C., & Schmidt, H. H. H. W. (2019). Calcium-dependent blood-brain barrier breakdown by NOX5 limits postreperfusion benefit in stroke. Journal of Clinical Investigation, 129(4), 1772-1778. https://doi.org/10.1172/JCI124283

Larsen, S. J., Rottger, R., Schmidt, H. H. H. W., & Baumbach, J. (2019). E. coli gene regulatory networks are inconsistent with gene expression data. Nucleic Acids Research, 47(1), 85-92. https://doi.org/10.1093/nar/gky1176

Beuve, A., Brouckaert, P., Burnett, J. C., Friebe, A., Garthwaite, J., Hobbs, A. J., Koesling, D., Kuhn, M., Potter, L. R., Russwurm, M., Schmidt, H., Stasch, J-P., & Waldman, S. A. (2019). Receptor guanylyl cyclase (RGC) family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE, 2019(4), 1-5. https://doi.org/10.2218/gtopdb/F1022/2019.4

Wiwie, C., Kuznetsova, I., Mostafa, A., Rauch, A., Haakonsson, A., Barrio-Hernandez, I., Blagoev, B., Mandrup, S., Schmidt, H. H. H. W., Pleschka, S., Röttger, R., & Baumbach, J. (2019). Time-Resolved Systems Medicine Reveals Viral Infection-Modulating Host Targets. Systems medicine (New Rochelle, N.Y.), 2(1), 1-9. https://doi.org/10.1089/sysm.2018.0013

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Egea, J., Fabregat, I., Frapart, Y. M., Ghezzi, P., Gorlach, A., Kietzmann, T., Kubaichuk, K., Knaus, U. G., Lopez, M. G., Olaso-Gonzalez, G., Petry, A., Schulz, R., Vina, J., Winyard, P., Abbas, K., Ademowo, O. S., Afonso, C. B., Andreadou, I., Antelmann, H., ... Daiber, A. (2018). European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS) (vol 13, pg 94, 2017). Redox Biology, 14, 694-696. https://doi.org/10.1016/j.redox.2017.10.001

Cuadrado, A., Manda, G., Hassan, A., Alcaraz, M., Barbas, C., Daiber, A., Ghezzi, P., Leon, R., Lopez, M. G., Oliva, B., Pajares, M., Rojo, A. I., Robledinos-Anton, N., Valverde, A. M., Guney, E., & Schmidt, H. H. H. W. (2018). Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach. Pharmacological Reviews, 70(2), 348-383. https://doi.org/10.1124/pr.117.014753