The ITEM annual conference in Groningen focused on the impact of border regions on security, health and energy supply for residents of Europe's internal borders. Current social developments in the fields of energy, health and safety still show that, in order to tackle barriers and work together with partners on both sides of the border, it is important to arrive at the right casuistry, a joint concrete agenda and a structural approach. The current energy challenge and the cross-border aspects involved require stronger intergovernmental governance (multilevel governance).